Granulomаtosis With Polyangiitis Affecting the Lung and Orbit
https://doi.org/10.20862/0042-4676-2021-102-2-109-115
Abstract
The paper describes a clinical case of pulmonary and right orbital injuries in granulomatosis with polyangiitis in a 38-year-old male. The case is of considerable interest due to the rarity of this pathology, especially because of the localization in the orbital region. The information provided in this paper can help in the early and accurate diagnosis of granulomatosis with polyangiitis, which, in turn, will improve the prognosis of the disease.
About the Authors
Zh. V. SheikhRussian Federation
Dr. Med. Sc., Professor, Radiology Chair; Professor, Chair of Radiation Diagnostics, Medical Biological University of Innovation and Continuing Education; Head of Department of Radiation Diagnostics
ul. Barrikadnaya, 2/1bld 1, Moscow, 125993, Russian Federation
ul. Marshala Novikova, 23, Moscow, 123098, Russian Federation
Vtoroy Botkinskiy proezd, 5, Moscow, 125284, Russian Federation
I. E. Tyurin
Russian Federation
Dr. Med. Sc., Professor, Chief of Radiology Chair
ul. Barrikadnaya, 2/1bld 1, Moscow, 125993, Russian Federation
T. D. Safonova
Russian Federation
Postgraduate, Radiology Chair
ul. Barrikadnaya, 2/1bld 1, Moscow, 125993, Russian Federation
A. M. Andreychenko
Russian Federation
Cand. Med. Sc., Department of Ophthalmooncology No. 1A
Vtoroy Botkinskiy proezd, 5, Moscow, 125284, Russian Federation
References
1. Sheikh ZhV, Zakharova ЕV, Dunaev АP. Systemic vasculitis: the possibilities of modern medical imaging. Мoscow: Kraft+; 2019 (in Russ.).
2. Semenkova Е.N. Systemic vasculitis. Мoscow: Meditsina; 1988 (in Russ.).
3. Bashkov AN, Sheikh ZhV, Dunaev AP, et al. Case report of the Charg-Strauss syndrome which simulated acute infectious bronchiolitis. radiologyst’s point of view. Russian Electronic Journal of Radiology. 2020; 10(1): 257–63 (in Russ.). https://doi.org/10.21569/2222-7415-2020-10-1-257-263.
4. Novikov PI, Moiseev SV, Kuznetsova EI, et al. Changing patterns of clinical severity and risk of mortality in granulomatosis with polyangiitis over four decades. Clinical Pharmacology and Therapy. 2014; 23(1): 32–7 (in Russ.).
5. Samsonova MV, Chernyaev AL. Histological differential diagnosis of granulomatous lung diseases (part I). Arkhiv Patologii. 2019; 81(1): 65–70 (in Russ.). https://doi.org/10.17116/patol20198101165.
6. Zerbino DD, Zimba EA. Morphological pathology of vessels in granulomatosis with polyangiitis (Wegener’s disease). Arkhiv Patologii. 2015; 77(5): 9–13 (in Russ.). https://doi.org/10.17116/patol20157759-13.
7. Rothschild PR, Pagnoux C, Seror R, et al. Ophthalmologic manifestations of systemic necrotizing vasculitides at diagnosis: a retrospective study of 1286 patients and review of the literature. Semin Arthritis Rheum. 2013; 42(5): 507–14. https://doi.org/10.1016/j.semarthrit.2012.08.003.
8. Martinez F, Chung JH, Digumarthy SR, et al. Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation. Radiographics. 2012; 32(1): 51–69. https://doi.org/10.1148/rg.321115060.
9. Lee KS, Kim TS, Fujimoto K, et al. Thoracic manifestation of Wegener’s granulomatosis: CT findings in 30 patients. Eur Radiol. 2003; 13(1): 43–51. https://doi.org/10.1007/s00330-002-1422-2.
10. Sheikh ZhV, Safonova TD. Computed tomography for the diagnosis of pulmonary lesions in patients with systemic vasculitis. Practical Pulmonology. 2019; 2: 69–74 (in Russ.).
11. Schaefer-Prokop C, Elicker BM. Diseases of the chest, breast, heart and vessels 2019–2022: diagnostic and interventional imaging. Chapter 11. Springer; 2019.
12. Mayberry JP, Primack SL, Müller NL. Thoracic manifestations of systemic autoimmune diseases: radiographic and highresolution CT findings. Radiographics. 2000; 20(6): 1623–35. https://doi.org/10.1148/radiographics.20.6.g00nv031623.
13. Kogan EA, Grusha IaO, Ismailova DS, et al. Refractory form of orbital granulomatosis with polyangiitis: a clinical and morphological study. Arkhiv Patologii. 2017; 79(1): 56–60 (in Russ.). https://doi.org/10.17116/patol201779156-60.
14. Tan LT, Davagnanam I, Isa H, et al. Clinical and imaging features predictive of orbital granulomatosis with polyangiitis and the risk of systemic involvement. Ophthalmology. 2014; 121(6): 1304–9. https://doi.org/10.1016/j.ophtha.2013.12.003.
15. Grusha IaO, Ismailova DS, Novikov PI, Abramova YuV. Ophthalmologic manifestations of granulomatosis with polyangiitis (Wegener’s granulomatosis). Terapevticheskii Arkhiv. 2015; 87(12): 111–6 (in Russ.). https://doi.org/10.17116/terarkh20158712111-116.
16. Holle JU, Voigt C, Both M, et al. Orbital masses in granulomatosis with polyangiitis are associated with a refractory course and a high burden of local damage. Rheumatology (Oxford). 2013; 52(5): 875–82. https://doi.org/10.1093/rheumatology/kes382.
Review
For citations:
Sheikh Zh.V., Tyurin I.E., Safonova T.D., Andreychenko A.M. Granulomаtosis With Polyangiitis Affecting the Lung and Orbit. Journal of radiology and nuclear medicine. 2021;102(2):109-115. (In Russ.) https://doi.org/10.20862/0042-4676-2021-102-2-109-115