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ДИАГНОСТИЧЕСКАЯ ЭФФЕКТИВНОСТЬ, БЕЗОПАСНОСТЬ И БИОЭКВИВАЛЕНТНОСТЬ ПРИМЕНЕНИЯ ГАДОБУТРОЛА У ДЕТЕЙ ДО 2 ЛЕТ ПО СРАВНЕНИЮ С БОЛЕЕ СТАРШИМИ ДЕТЬМИ И ВЗРОСЛЫМИ


https://doi.org/10.20862/0042-4676-2017-98-2-97-102

Полный текст:


Аннотация

Приведены сведения о безопасности, диагностической эффективности и биоэквивалентности применения гадобутрола у новорожденных и младенцев по сравнению с детьми более старшего возраста и взрослыми пациентами. Профиль фармакокинетики гадобутрола у детей в возрасте младше 2 лет, включая доношенных новорожденных, аналогичен тому, что имеет место у детей более старшего возраста и взрослых. При стандартной дозе 0,1 ммоль/кг массы тела гадобутрол имеет благоприятный профиль безопасности и хорошо переносится детьми любого возраста и взрослыми. Получены доказательства возможности экстраполяции применения гадобутрола у детей младше 2 лет, включая доношенных новорожденных, для эффективной диагностики нарушений гематоэнцефалического барьера и патологических изменений сердечно-сосудистой системы и очаговых заболеваний других внутренних органов.

Об авторах

А. А. Алиханов
ФГБУ «Российская детская клиническая больница» Минздрава России
Россия

д. м. н., профессор, заведующий отделением лучевой диагностики,

Ленинский пр-т, 117, Москва, 119571



Н. Л. Шимановский
ФГБОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России
Россия

д. м. н., профессор, чл.-корр. РАН, заведующий кафедрой молекулярной фармакологии и радиобиологии им. академика П.В. Сергеева,

ул. Островитянова, 1, Москва, 117997



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Дополнительные файлы

Для цитирования: Алиханов А.А., Шимановский Н.Л. ДИАГНОСТИЧЕСКАЯ ЭФФЕКТИВНОСТЬ, БЕЗОПАСНОСТЬ И БИОЭКВИВАЛЕНТНОСТЬ ПРИМЕНЕНИЯ ГАДОБУТРОЛА У ДЕТЕЙ ДО 2 ЛЕТ ПО СРАВНЕНИЮ С БОЛЕЕ СТАРШИМИ ДЕТЬМИ И ВЗРОСЛЫМИ. Вестник рентгенологии и радиологии. 2017;98(2):97-102. https://doi.org/10.20862/0042-4676-2017-98-2-97-102

For citation: Alikhanov A.A., Shimanovskiy N.L. THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS. Journal of radiology and nuclear medicine. 2017;98(2):97-102. (In Russ.) https://doi.org/10.20862/0042-4676-2017-98-2-97-102

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ISSN 0042-4676 (Print)
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