CHEMOEMBOLIZATION FOR UNRESECTABLE COLORECTAL LIVER METASTASES WITH DRUG-ELUTING MICROSPHERES
https://doi.org/10.20862/0042-4676-2014-0-6-33-38
Abstract
Objective: to evaluate the efficiency of chemoembolization using irinotecan-loaded DC Bead microspheres in the second-line chemotherapy for colorectal liver metastases.
Material and methods. In 2008 to 2013, thirty-two patients with unresectable colorectal liver metastases underwent 78 chemoembolizations (mean 2.44 per patient). The results of embolization were assessed by computed tomography using the Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Survival rates were analyzed applying the Kaplan–Meier method.
Results. According to the RECIST criteria, a partial response at 3, 6, and 12 months of treatment was found in 4, 2, and 0%, respectively. Stabilization was noted in 67, 53, and 12%. There were no complete responses. The median time to disease progression was 225 days; median survival was 420 days. By the study analysis, all the patients included in the study died.
Conclusion. Chemoembolization with drug-eluting microspheres may be successfully used in the second-line chemotherapy of colorectal liver metastases.
About the Authors
A. V. Skupchenko
Samara Regional Clinical Oncology Dispensary
Russian Federation
Russian Federation
MD, PhD, Head of Department of X-ray Surgical Methods for Diagnosis and Treatment
ul. Solnechnaya, 50, Samara, 44303
A. V. Lysenko
Samara Regional Clinical Oncology Dispensary
Russian Federation
Russian Federation
Physician
ul. Solnechnaya, 50, Samara, 44303
D. G. Korolev
Samara Regional Clinical Oncology Dispensary
Russian Federation
Russian Federation
Physician
ul. Solnechnaya, 50, Samara, 44303
D. A. Skobel’tsov
Samara Regional Clinical Oncology Dispensary
Russian Federation
Russian Federation
Physician
ul. Solnechnaya, 50, Samara, 44303
A. S. Rassudishkin
Samara Regional Clinical Oncology Dispensary
Russian Federation
Russian Federation
Physician
ul. Solnechnaya, 50, Samara, 44303
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Review
For citations:
Skupchenko A.V., Lysenko A.V., Korolev D.G., Skobel’tsov D.A., Rassudishkin A.S. CHEMOEMBOLIZATION FOR UNRESECTABLE COLORECTAL LIVER METASTASES WITH DRUG-ELUTING MICROSPHERES. Journal of radiology and nuclear medicine. 2014;(6):33-38. (In Russ.) https://doi.org/10.20862/0042-4676-2014-0-6-33-38
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