Preview

Journal of radiology and nuclear medicine

Advanced search

Experience in Using 99mTc-Technephyt Esophageal Transit Scintigraphy for Assessing Pneumatic Dilation Outcome in Patients with Achalasia Cardia

https://doi.org/10.20862/0042-4676-2024-105-3-120-129

Abstract

Objective: to show the possibility of using 99mTc-technephyt esophageal transit scintigraphy (ETS) to assess the effect of cardiodilation in patients with achalasia cardia.
Material and methods. We examined 7 patients (6 males and 1 female) aged 44–73 years (mean age 57.8 years) diagnosed with achalasia cardia, who were treated in Department of Thoracic Surgery No. 2 at Republican Clinical Hospital from June 2022 to January 2023. The disease duration before admission to the hospital ranged from 2 to 17 years (mean 9.2 years).
Results. The analysis of ETS results showed a decreased radiopharmaceutical residual activity percentage in cardia for all patients after treatment compared with the initial data. It indicated a positive effect of cardiodilation and coincided with X-ray examination data. The obtained results demonstrate the possibility of ETS using and its practical significance to assess the effect of therapeutic measures, in particular cardiodilation, in patients with achalasia cardia.
Conclusion. Performed according to the described protocol, ETS is a physiological and safe method for both the diagnosis of achalasia and the subsequent assessing therapeutic effect, including cardiodilation, myotomy, conservative treatment, and long-term dynamic monitoring. It is a physiological and safe procedure, which can be recommended in cases of difficulties in evaluating the esophageal function by X-ray, endoscopic and manometric methods or when their use is impossibile.

About the Authors

R. A. Bashirov
Russian Medical Academy of Continuing Professional Education; Kazan State Medical University; Republican Clinical Hospital
Russian Federation

Rustem A. Bashirov, Assistant Professor, Academicians Pavlov and Krotkov Chair of Radiotherapy and Radiology; Assistant Professor, Chair of Oncology, Radiation Diagnostics and Radiation Therapy; Radiologist, Department of Radiology

Vtoroy Botkinskiy proezd, 7, Moscow, 125284

ul. Butlerova, 49, Kazan, 420012

Orenburgskiy trakt, 138, Kazan, 420064



A. I. Shelepova
Kazan State Medical University
Russian Federation

Angelina I. Shelepova, Resident, Chair of Oncology, Radiation Diagnostics and Radiation Therapy

ul. Butlerova, 49, Kazan, 420012



L. E. Samoilenko
Russian Medical Academy of Continuing Professional Education
Russian Federation

Lyudmila E. Samoilenko, Dr. Med. Sc., Professor, Academicians Pavlov and Krotkov Chair of Radiotherapy and Radiology

Vtoroy Botkinskiy proezd, 7, Moscow, 125284



S. A. Ryzhkin
Russian Medical Academy of Continuing Professional Education; Kazan State Medical University; Kazan (Volga Region) Federal University
Russian Federation

Sergey A. Ryzhkin, Dr. Med. Sc., Associate Professor, Corresponding Member of Academy of Sciences of the Republic of Tatarstan, Chief of Academicians Pavlov and Krotkov Chair of Radiotherapy and Radiology; Professor, Chair of General Hygiene; Professor, Chair of Medical Physics, Institute of Physics

Vtoroy Botkinskiy proezd, 7, Moscow, 125284

ul. Butlerova, 49, Kazan, 420012

ul. Kremlevskaya, 18, korp. 1, Kazan, 420008



B. M. Sharafutdinov
Kazan (Volga Region) Federal University; Kazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional Education
Russian Federation

Bulat M. Sharafutdinov, Cand. Med. Sc., Head of Department of Endovascular Surgical Methods of Diagnosis and Treatment, Medical and Sanitary Unit; Assistant Professor, Department of Cardiology, Endovascular and Cardiovascular Surgery

ul. Kremlevskaya, 18, korp. 1, Kazan, 420008

ul. Butlerova, 36, Kazan, 420012,



A. F. Yusupova
Kazan State Medical University
Russian Federation

Alsu F. Yusupova, Cand. Med. Sc., Associate Professor, Chair of Oncology, Radiation Diagnostics and Radiation Therapy

ul. Butlerova, 49, Kazan, 420012



L. F. Ziganshina
Kazan State Medical University; Republican Clinical Hospital
Russian Federation

Lilia F. Ziganshina, Cand. Med. Sc., Assistant Professor, Chair of Oncology, Radiation Diagnostics and Radiation Therapy; Head of Department of Radiology

ul. Butlerova, 49, Kazan, 420012

Orenburgskiy trakt, 138, Kazan, 420064



B. A. Magomedov
Republican Clinical Hospital
Russian Federation

Bulyamin A. Magomedov, Thoracic Surgeon

Orenburgskiy trakt, 138, Kazan, 420064



A. I. Kukushkin
Republican Clinical Hospital
Russian Federation

Andrey I. Kukushkin, Head of Department of Thoracic Surgery No. 2, Junior Researcher

Orenburgskiy trakt, 138, Kazan, 420064



V. Yu. Matveev
Republican Clinical Hospital
Russian Federation

Valeriy Yu. Matveev, Cand. Med. Sc., Head of Department of Thoracic Surgery No. 1, Leading Researcher

Orenburgskiy trakt, 138, Kazan, 420064



D. R. Bashirov
Sadykov City Clinical Hospital No. 7
Russian Federation

Damir R. Bashirov, Radiologist

Sadykov City Clinical Hospital No. 7



References

1. National clinical guidelines. Achalasia cardia. 2021. 66 pp (in Russ).

2. Ivashkin VT, Trukhmanov AS, Godzhello EA, et al. Diagnostics and treatment of cardiac achalasia and cardiospasm: guidelines of the Russian gastroenterological association. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016; 26(4): 36–54 (in Russ). https://doi.org/10.22416/1382-4376-2016-4-36-54.

3. De León AR, de la Serna JP, Santiago JL, et al. Association between idiopathic achalasia and IL23R gene. Neurogastroenterol Motil. 2010; 22(7): 734–8. https://doi.org/10.1111/j.1365-2982.2010.01497.x.

4. Tullio-Pelet A, Salomon R, Hadj-Rabia S, et al. Mutant WD-repeat protein in triple-A syndrome. Nat Genet. 2000; 26(3): 332–5. https://doi.org/10.1038/81642.

5. Batista AM, Aguiar C, Almeida EA, et al. Evidence of Chagas disease in seronegative Brazilian patients with megaesophagus. Int J Infect Dis. 2010; 14(11): e974–7. https://doi.org/10.1016/j.ijid.2010.05.017.

6. Niwamoto H, Okamoto E, Fujimoto J, et al. Are human herpes viruses or measles virus associated with esophageal achalasia? Dig Dis Sci. 1995; 40(4): 859–64. https://doi.org/10.1007/BF02064992.

7. Booy JD, Takata J, Tomlinson G, Urbach DR. The prevalence of autoimmune disease in patients with esophageal achalasia. Dis Esophagus. 2012; 25(3): 209–13. https://doi.org/10.1111/j.1442-2050.2011.01249.x.

8. Kraichely RE, Farrugia G, Pittock SJ, et al. Neural autoantibody profile of primary achalasia. Dig Dis Sci. 2010; 55(2): 307–11. https://doi.org/10.1007/s10620-009-0838-9.

9. Yevsyutina YuV, Storonova OA, Trukhmanov AS, Ivashkin VT. Cardiac achalasia: modern concepts on etiology, pathogenesis, clinical presentation and diagnostics. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2014; 24(5): 2–14 (in Russ).

10. Chernousov AF, Khorobrykh TV, Vetshev FP, et al. Complex treatment of patients with achalasia of cardia and cardiospasm subject to psychosomatic disorders. Clinical Medicine (Russian Jornal). 2018; 96(5): 419–26 (in Russ). https://doi.org/10.18821/0023-2149-2018-96-5-419-426.

11. Eckardt VF, Aignherr C, Bernhard G. Predictors of outcome in patients with achalasia treated by pneumatic dilation. Gastroenterology. 1992; 103(6): 1732–8. https://doi.org/10.1016/0016-5085(92)91428-7.

12. Karpov OJe, Vetshev PS, Vasilyev IV, et al. Endoscopic techniques in the diagnosis and treatment of achalasia cardii. Bulletin of Pirogov National Medical and Surgical Center. 2016; 11(1): 30–6 (in Russ).

13. Oude Nijhuis RAB, Zaninotto G, Roman S, et al. European guideline on achalasia – UEG and ESNM recommendations. United European Gastroenterol J. 2020; 8(1): 13–34. https://doi.org/10.1177/2050640620903213.

14. Vaezi MF, Pandolfino JE, Yadlapati RH, et al. ACG clinical guidelines: diagnosis and management of achalasia. Am J Gastroenterol. 2020; 115(9): 1393–411. https://doi.org/10.14309/ajg.0000000000000731.

15. Boys J, Oh DS, Seto J, et al. Quantitative assessment of esophageal emptying in achalasia patients using esophageal transit scintigraphy. The Society for Surgery of the Alimentary Tract, 56th Annual Meeting. May 16–19, 2015. Washington, DC. Available at: https://meetings.ssat.com/abstracts/2015/Mo1639.cgi (accessed 14.04.2024).

16. Janković Z, Pucar D, Doder R, Perišić N. Esophageal two-phase supine/standing scintigraphy and balloon dilatation in achalasia: 20 years of experience. Vojnosanit Pregl. 2021; 78(4): 429–34. https://doi.org/10.2298/VSP190226087J.


Review

For citations:


Bashirov R.A., Shelepova A.I., Samoilenko L.E., Ryzhkin S.A., Sharafutdinov B.M., Yusupova A.F., Ziganshina L.F., Magomedov B.A., Kukushkin A.I., Matveev V.Yu., Bashirov D.R. Experience in Using 99mTc-Technephyt Esophageal Transit Scintigraphy for Assessing Pneumatic Dilation Outcome in Patients with Achalasia Cardia. Journal of radiology and nuclear medicine. 2024;105(3):120-129. (In Russ.) https://doi.org/10.20862/0042-4676-2024-105-3-120-129

Views: 551


ISSN 0042-4676 (Print)
ISSN 2619-0478 (Online)