Multiple Myeloma with Intracranial Distribution
https://doi.org/10.20862/0042-4676-2023-104-1-56-61
Abstract
Multiple myeloma (MM) is a malignant immunoproliferative disease involving plasma cells, leading to their malignant proliferation and the production of monoclonal paraproteins. Intracranial tumor spread in MM is very rare. This is a unique and infrequent localization, which makes it difficult to diagnose the disease. We report a rare case of treatment of a patient with MM intracranial spread, whose disease was presumably in remission and recurred as an intracranial plasmacytoma with a clinical picture of acute cerebrovascular accident. Surgical intervention was performed to remove the tumor, a histopathological analysis of the removed tissue was carried out. Even with early diagnosis, the prognosis remains bleak, with median survival rates of 3 to 6 months. However, aggressive multimodal treatment can prolong life by months.
About the Authors
A. Yu. Rynda
City Mariinsky Hospital
Russian Federation
Russian Federation
Artemii Yu. Rynda, Cand. Med. Sc., Neurosurgeon, Neurosurgery Department
Liteynyy prospekt, 56, Saint Petersburg, 191014
О. А. Pavlov
City Mariinsky Hospital
Russian Federation
Russian Federation
Оleg А. Pavlov, Cand. Med. Sc., Head of Neurosurgery Department
Liteynyy prospekt, 56, Saint Petersburg, 191014
О. P. Verbitskiy
City Mariinsky Hospital
Russian Federation
Russian Federation
Оleg P. Verbitskiy, Cand. Med. Sc., Neurosurgeon, Neurosurgery Department
Liteynyy prospekt, 56, Saint Petersburg, 191014
D. А. Sitovskaya
City Mariinsky Hospital
Russian Federation
Russian Federation
Daria А. Sitovskaya, Pathologist, Pathomorphology Department
Liteynyy prospekt, 56, Saint Petersburg, 191014
M. Yu. Podgornyak
City Mariinsky Hospital
Russian Federation
Russian Federation
Marina Yu. Podgornyak, Cand. Med. Sc., Neurosurgeon, Neurosurgery Department
Liteynyy prospekt, 56, Saint Petersburg, 191014
References
1. Rajkumar SV, Dimopoulos MA, Palumbo A. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncology. 2014; 15(12): e538–48a. https://doi.org/10.1016/S1470-2045(14)70442-5.
2. Firsova MV, Mendeleeva LP, Kovrigina AM, et al. Clinical features of the extramedullary disease in multiple myeloma. Russian Journal of Hematology and Transfusiology. 2017; 62(2): 75–82 (in Russ.).
3. Firsova MV, Mendeleeva LP, Kovrigina AM, et al. Plasmacytoma in patients with multiple myeloma: morphology and immunohistochemistry. BMC Cancer. 2020; 20: 346. https://doi.org/10.1186/s12885-020-06870-w.
4. Touzeau С, Moreau P. How I treat extramedullary myeloma. Blood. 2016; 127(8): 971–6. https://doi.org/10.1182/blood-2015-07-635383.
5. Anderson KC, Carrasco RD. Pathogenesis of myeloma. Ann Rev Pathol. 2011; 6: 249–74. https://doi.org/10.1146/annurev-pathol-011110-130249.
6. Becker N. Epidemiology of multiple myeloma. Recent Results Cancer Res. 2011; 183: 25–35. https://doi.org/10.1007/978-3-540-85772-3_2.
7. Breen DP, Freeman CL, De Silva RN, et al. Soft tissue plasmacytomas in multiple myeloma. Lancet. 2017; 390(10107): 2083. https://doi.org/10.1016/S0140-6736(17)31471-X.
8. Duma N, Patel D, Nasereddin T. Parietal plasmacytoma: an ominous sign of disease recurrence. Am J Med Case Rep. 2015; 3(6): 163–6. https://doi.org/10.12691/ajmcr-3-6-4.
9. Trejos AM, Cuartas MC, Korenfeld MY, et al. Giant forehead plasmacytoma as a growing lump in a patient with multiple myeloma. Radiol Case Rep. 2020; 15(12): 2589–93. https://doi.org/10.1016/j.radcr.2020.09.050.
10. Senapati SB, Mishra SS, Dhir MK, et al. A case of multiple myeloma presenting as scalp swelling with intracranial extension. J Neurosci Rural Pract. 2013; 4(4): 445–8. https://doi.org/10.4103/0976-3147.120230.
11. Sukriti S, Li Z, Xinxiang Z. Imaging findings of solitary plasmacytoma of the cranium. Arch Clin Med Case Rep. 2018; 2: 231–40.
12. Abbas H, Karimianpour A, Pennell NA. Fast-growing plasmacytoma. Images in the medical sciences. 2016; 351(3): 308. https://doi.org/10.1016/j.amjms.2016.01.002.
13. Siyag A, Soni TP, Gupta AK, et al. Plasmacytoma of the skullbase: a rare tumor. Cureus. 2018; 10(1): e2073. https://doi.org/10.7759/cureus.2073.
Review
For citations:
Rynda A.Yu., Pavlov О.А., Verbitskiy О.P., Sitovskaya D.А., Podgornyak M.Yu. Multiple Myeloma with Intracranial Distribution. Journal of radiology and nuclear medicine. 2023;104(1):56-61. (In Russ.) https://doi.org/10.20862/0042-4676-2023-104-1-56-61
Views:
667
Email this article 