Диффузно растущие опухоли ствола мозга у детей и подростков: изменила ли результаты изменяющаяся тактика лечения?
https://doi.org/10.20862/0042-4676-2015-0-1-1-27
Аннотация
Проведен анализ публикаций в Medline за последние 20 лет, посвященных лечению диффузно растущих опухолей ствола мозга у детей и подростков. Основным методом лечения этих заболеваний остаются лучевая и химиолучевая терапия. Использование различных вариантов фракционирования дозы облучения и разных комбинаций цитотоксических препаратов не привело к существенным изменениям отдаленных результатов. Большинство больных, независимо от варианта примененного лечения, умирают в течение ближайших 1–2 лет от прогрессирования опухоли. Прогноз в основном зависит от биологических свойств опухоли, в течение длительного срока живут, как правило, больные с вариантами глиом низкой злокачественности. Качество жизни длительно живущих после лечения больных в разной степени страдает из-за отдаленных последствий лучевой терапии. Надежды на повышение эффективности лечения связаны с разработкой методов таргетной терапии на основе молекулярно-биологических маркеров.
Об авторе
О. И. Щербенко
ФГБУ «Российский научный центр рентгенорадиологии» Министерства здравоохранения РФ
Россия
д. м. н., профессор, вед. науч. сотр. лаборатории комплексных методов лечения онкологических заболеваний у детей
Россия
д. м. н., профессор, вед. науч. сотр. лаборатории комплексных методов лечения онкологических заболеваний у детей
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Рецензия
Для цитирования:
Щербенко О.И. Диффузно растущие опухоли ствола мозга у детей и подростков: изменила ли результаты изменяющаяся тактика лечения? Вестник рентгенологии и радиологии. 2015;(1):43-51. https://doi.org/10.20862/0042-4676-2015-0-1-1-27
For citation:
Shcherbenko O.I. Diffusely growing brainstem tumors in children and adolescents: Has alternating treatment policy changed results? Journal of radiology and nuclear medicine. 2015;(1):43-51. (In Russ.) https://doi.org/10.20862/0042-4676-2015-0-1-1-27
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