Invasive Mucormycosis with Lung Involvement in a Female Patient with Aplastic Anemia
https://doi.org/10.20862/0042-4676-2019-100-4-215-221
Abstract
Mucormycosis is an infection caused by one of several types of mold. Invasive mucormycosis is the most aggressive, rapidly progressive fungal infection. The disease is characterized by high attributable mortality. The early and accurate diagnosis of invasive mucormycosis determines the choice of an adequate therapeutic policy, by improving the prognosis of the disease. The method of choice for diagnosing pulmonary mucormycosis is computed tomography that allows accurate determination of the location and extent of the lesion, the state of the lung parenchyma, and the presence of concomitant complications. The paper describes a clinical case of damage to the lung and skin in invasive mucormycosis in a 28-year-old woman with aplastic anemia. The case is of interest due to a larger number of immunocompromised patients, especially those susceptible to the disease.
About the Authors
Zh. V. SheikhRussian Federation
Dr. Med. Sc., Professor, Head of Сomputed Tomography Department
I. E. Tyurin
Russian Federation
Dr. Med. Sc., Professor, Chief of Radiology Chair
A. I. Sinopal’nikov
Russian Federation
Dr. Med. Sc., Professor, Chief of Pulmonology Chair
A. V. Arablinskiy
Russian Federation
Dr. Med. Sc., Professor, Head of Radiodiagnosis Department
T. D. Safonova
Russian Federation
Clinical Resident of Radiology Chair
E. V. Fedyaeva
Russian Federation
Clinical Resident of Radiology Chair
O. B. Murav’ev
Russian Federation
Cand. Med. Sc., Head of Department of Anesthesiology and Resuscitation for Infectious Patients
S. N. Shvayko
Russian Federation
Cand. Med. Sc., Head of Pulmonology Department
References
1. Samsonova M.V., Сhernyaev А.L., Lebedin Yu.S., Mikhaylichenko К.Yu., Polivanova A.E. Mucormycosis of the lungs. Russian Pulmonology. 2018; 28 (2): 243–7 (in Russ.). DOI: 10.18093/0869-0189-2018-28-2-243-247
2. Klimko N.N. Mycoses: diagnosis and treatment. Guide for doctors. Moscow: WGGroup; 2008 (in Russ.).
3. Skiada A., Pagano L., Groll A., Zimmerli S., Dupont B., Lagrou K. Zygomycosis in Europe: analysis of 230 cases accrued by the registry of the European Confederation of Medical Mycology (ECMM) Working Group on Zygomycosis between 2005 and 2007. Clin. Microbiol. Infect. 2011; 17 (12): 1859–67. DOI: 10.1111/j.1469-0691.2010.03456
4. Lanternier F., Dannaoui E., Morizot G., Elie C., Garcia-Hermoso D., Huerre M. A global analysis of mucormycosis in France: the Retro Zygo Study (2005–2007). Clin. Infect. Dis. 2012; 54 (Suppl. 1): 35–43. DOI: 10.1093/cid/cir880
5. Meis J.F., Chakrabarti A. Changing epidemiology of an emerging infection: zygomycosis. Clin. Microbiol. Infect. 2009; 15 (Suppl. 5): 10–4. DOI: 10.1111/j.1469-0691.2009.02973
6. Khostelidi S.N., Shapochnik А.P., Monina Yu.V., Zaytsev S.B., Bogomolova T.S., Klimko N.N. Disseminated mucormycosis by a patient with acute lymphoblastic leukemia (clinical case). Journal Infectology. 2013; 5 (3): 74–9 (in Russ.). DOI: 10.22625/2072-6732-2013-5-3-74-79
7. Sheykh Zh.V., Zakharova Е.V., Dunaev А.P. CT in the diagnosis of pulmonary lesions by granulomatosis with polyangiitis. Moscow: Kraft+; 2017 (in Russ.).]
Review
For citations:
Sheikh Zh.V., Tyurin I.E., Sinopal’nikov A.I., Arablinskiy A.V., Safonova T.D., Fedyaeva E.V., Murav’ev O.B., Shvayko S.N. Invasive Mucormycosis with Lung Involvement in a Female Patient with Aplastic Anemia. Journal of radiology and nuclear medicine. 2019;100(4):215-221. (In Russ.) https://doi.org/10.20862/0042-4676-2019-100-4-215-221