ULTRASOUND MONITORING OF CONSOLIDATION PROCESSES IN FRACTURES OF LONG TUBULAR BONES IN OSTEOSYNTHESIS USING BIOACTIVE IMPLANTS
https://doi.org/10.20862/0042-4676-2014-0-5-40-48
Abstract
Objective: to show the capabilities of ultrasound monitoring to assess consolidation processes in fractures of long tubular bones in the use of bioactive material-containing implants.
Material and methods. Eighty-two (45.1%) patients whose bone fragments had been fixed with bioactive material-coated plates and 100 (54.9%) patients with bioinert material-coated ones were examined. Consolidation changes were estimated by ultrasound and X-ray studies 2, 4, 6, and 12 months after surgery. Bone metabolic changes were determined by US osteometry 2 months following surgery. Ultrasound data were compared with the biochemical markers: C-terminal telopeptide (CrossLaps) and osteocalcin.
Results and conclusions. Ultrasound monitoring of the rates of consolidation and the time course of changes in bone strength versus the biochemical markers established the positive effect of bioactive plates on the process of consolidation in fractures of tubular bones and made it possible to consider local osteopenic syndrome to be a prognostically favorable sign of timely callus formation.
About the Authors
V. D. ZavadovskayaRussian Federation
MD, PhD, DSc, Professor, Head of Chair of Radiation Diagnosis and Radiotherapy
Moskovskiy trakt, 2, Tomsk, 634050
V. P. Popov
Russian Federation
MD, PhD, Assistant to Chair of Traumatology, Orthopedics and Field Surgery
Moskovskiy trakt, 2, Tomsk, 634050
O. E. Akbasheva
Russian Federation
MD, PhD, DSc, Associate Professor to Chair of Biochemistry and Molecular Biology
Moskovskiy trakt, 2, Tomsk, 634050
E. G. Grigor’ev
Russian Federation
MD, PhD, Assistant to Chair of Radiation Diagnosis and Radiotherapy
Moskovskiy trakt, 2, Tomsk, 634050
T. V. Druzhinina
Russian Federation
MD, PhD, Head of Department of Biomedical Technologies
ul. Sabirovskaya, 37, St. Petersburg, 197183
References
1. Агаджанян В.В., Агаларян А.К. Научно-организационные технологии оказания медицинской помощи пострадавшим с политравмами при доминирующих повреждениях внутренних органов. Политравма. 2012; 3: 5–10. Agadzhanyan V.V., Agalaryan A.K. Scientific and organizational techniques of medical care in patients with multiple injuries and dominant internal injuries. Politravma. 2012; 3: 5–10 (in Russian).
2. Серкова Е.В. Медико-социальные аспекты травматизма и пути совершенствования системы оказания медицинской помощи пострадавшим с переломами костей конечностей (комплексное социально-эпидемиологическое исследование на примере Курганской области): Автореф. дис. … канд. мед. наук. Екатеринбург; 2011. Serkova E.V. Medical and social aspects of injuries and ways to improve the health care system suffered from bone fractures (Comprehensive socio-epidemiological study on the Kurgan region): PhD med. sci. Thesis in Diss. Ekaterinburg; 2011 (in Russian).
3. Легостаева Е.В., Шаркеев Ю.П., Гнеденков С.В., Комарова Е.Г., Егоркин В.С., Синебрюхов С.Л. и др. Микродуговые кальцийфосфатные покрытия по поверхности наноструктурированного титана: морфология, физико-механические и электрохимические свойства. Материаловедение. 2013; 4: 48–56. Legostaeva E.V., Sharkeev Yu.P., Gnedenkov S.V., Komarova E.G., Egorkin V.S., Sinebryukhov S.L. et al. Microarc calcium phosphate coating on titanium surface nanostructuring: morphology, physical, mechanical and electrochemical properties. Materialovedenie. 2013; 4: 48–56 (in Russian)
4. Попов В.П., Хлусов И.А., Шаркеев Ю.П. Экспериментальное обоснование in vitro остеогенных свойств кальций-фосфатных покрытий с различным фазовым составом. Политравма. 2012; 3: 72–7. Popov V.P., Khlusov I.A. Sharkeev Yu.P. Experimental study in vitro of osteogenic properties of calcium phosphate coatings with different phase composition. Politravma. 2012; 3: 72–7 (in Russian).
5. Rahimzadeh R., Veshkini A., Sharifi D., Hesaraki S.V. Value of color Doppler ultrasonography and radiography for the assessment of the cancellous bone scaffold coated with nano-hydroxyapatite in repair of radial bone in rabbit. Acta Cir. Bras. 2012; 27 (2): 148–54.
6. Zhu W., Xiao J., Wang D., Liu J., Xiong J., Liu L. et al. Experimental study of nano-HA artificial bone with different pore sizes for repairing the radial defect. Int. Orthop. 2009; 33 (2): 567–71.
7. Власова И.С. Современные методы лучевой диагностики остеопороза. Вестник рентгенологии и радиологии. 2002; 1: 37–42. Vlasova I.S. Modern methods of radiological diagnosis of osteoporosis. Vestnik rentgenologii i radiologii. 2002; 1: 37–42 (in Russian).
8. Рожинская Л.Я. Системный остеопороз: Практическое руководство для врачей. 2-е изд., перераб. и доп. М.: Издатель Мокеев; 2000. Rozhinskaya L.Ya. Systemic osteoporosis: A practical guide for physicians. 2nd ed., Rev. and add. Moscow: Izdatel’ Mokeev; 2000 (in Russian).
9. Guglielmi G., Adams J., Link T. Quantitative ultrasound in the assessment of skeletal status. Eur. Radiol. 2009; 19: 1837–48.
10. Урьев В.Г. Возможности эхографии в оценке состояния дистракционного регенерата при удлинении верхних и нижних конечностей. Ультразвуковая и функциональная диагностика. 2007; 2: 230. Ur’ev V.G. Capabilities of ultrasound in the assessment of distraction regenerate when extending upper and lower extremities. Ul’trazvukovaya i funktsional’naya diagnostika. 2007; 2: 230 (in Russian)
11. Bruno C. Gray-scale ultrasonography in the evaluation of bone callus in distraction osteogenesis of the mandible: initial findings. Eur. Radiol. 2008; 18: 1012–7.
12. Guglielmi G., Scalzo G., de Terlizzi F., Peh W.C. Evaluation of distracted mandibular bone using computed tomography scan and ultrasonography: technical note. Dentomaxillofac. Radiol. 2009; 38 (5): 274–80.
13. Selim H., Elbargothy N., Nabil Y., El-Hakim I. Evaluation of distracted mandibular bone using computed tomography scan and ultrasonography: technical note. Dentomaxillofac. Radiol. 2009; 38 (5): 274–80.
14. Завадовская В.Д., Нигматова Э.Ш., Килина О.Ю. Ультразвуковая остеометрия в оценке костной прочности при массовых осмотрах населения. Мед. визуализация. 2005; 6: 13–8. Zavadovskaya V.D., Nigmatova E.Sh., Kilina O.Yu. Ultrasonic osteometriya in an assessment of bone strength in mass examinations of the population. Meditsinskaya vizualizatsiya. 2005; 6: 13–8 (in Russian).
15. Guglielmi G., Scalzo G., de Terlizzi F., Peh W.C. Quantitative ultrasound in osteoporosis and bone metabolism pathologies. Radiol. Clin. North Am. 2010; 48 (3): 577–88.
Review
For citations:
Zavadovskaya V.D., Popov V.P., Akbasheva O.E., Grigor’ev E.G., Druzhinina T.V. ULTRASOUND MONITORING OF CONSOLIDATION PROCESSES IN FRACTURES OF LONG TUBULAR BONES IN OSTEOSYNTHESIS USING BIOACTIVE IMPLANTS. Journal of radiology and nuclear medicine. 2014;(5):40-48. (In Russ.) https://doi.org/10.20862/0042-4676-2014-0-5-40-48