СOMPARISON OF LOW- AND HIGH-CONCENTRATION (270 AND 320 MG I/ML) ISO-OSMOLAR IODINATED CONTRAST MEDIA IN CORONARY CT ANGIOGRAPHY: A RANDOMIZED PROSPECTIVE SINGLE-CENTER BLINDED STUDY

Objective: to compare the image quality at coronary multidetector computed tomography (MDCT) using low-dose and lowiodine protocol study in comparison with the standard protocol.

Material and methods. In study included 60 patients undergoing coronary computed tomography angiography. All examinations were performed with 64-row MDCT using prospective ECG-gating and ASIR 40%. 30 patients were examined using a low-concentration (Iodixanol, 270 mg I/ml) iodinated contrast medium and low tube voltage (80 kV) (group 1), 30 patients – using of high-concentration (Iodixanol, 320 mg I/ml) iodinated contrast medium and standard tube voltage (120 kV) (group 2). Image quality of coronary arteries was evaluated using a fourpoint grading scale, images were randomised. Intra-arterial density was measured for the proximal and distal segments of left anterior descending artery (LAD) and right coronary artery (RCA).

Results. Age, heart rate, BMI and scan parameters were not statistically different between the two groups. Analysis of coronaries visualization revealed the same image quality for group 1 and group 2 (image quality scores were 1,28 ± 0,28 vs. 1,34 ± 0,29, р=0,4). There was no significant difference between mean enhancement values in the distal segments of RCA and LAD for the two groups. Intraarterial density for proximal LAD and proximal RCA for the group 2 were significantly lower (p<0,05) than those values for the group 1.

Conclusion. The use of low-dose and low-iodine protocol can be beneficial for patient safety and for image quality without loss of diagnostic information.

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