Whole-body diffusion-weighted magnetic resonance imaging by estimating the measurable diffusion coefficient in Hodgkin lymphoma
https://doi.org/10.20862/0042-4676-2015-0-2-28-34
Abstract
Objective: to determine whether the measurable diffusion coefficient (MIC) may be used to differentiate normal and lymphomatosisaltered lymph nodes (LNs) in patients with Hodgkin lymphoma (HL).
Material and methods. Whole-body magnetic resonance (MR) imaging was used to compare the MICs of LNs in 27 apparently healthy individuals and 41 patients with a verified diagnosis of HL.
Results. Construction of 95% confidence intervals showed that the MICs of normal LNs were in the range of 1.00 to 1.73× ×10-3 mm2/sec and significantly higher (p<0.05) than those of lymphomatosis-affected LNs (MIC, 0.59 to 0.94×10-3 mm2/sec). The cut-off point (for discretization) of normal and lymphomatosis-altered LNs was in the range of 0.94 to 1.00×10-3 mm2/sec. Consequently, the LN with a MIC of less than 0.94×10-3 mm2/sec may be thought of as affected by the lymphomatous process.
Conclusion. MIC calculation permits differentiation of normal and affected LNs having equal signal characteristics (including those on diffusion-weighted MR images).
About the Authors
A. I. Mikhaylov
Russian Medical Academy of Postgraduate Education, Ministry of Health of the RF
Russian Federation
Postgraduate
Russian Federation
Postgraduate
V. O. Panov
Russian Medical Academy of Postgraduate Education, Ministry of Health of the RF
Russian Federation
MD, PhD, Associate Professor of Department of Radiation Diagnosis,
Radiotherapy and Medical Physics;
Russian Federation
MD, PhD, Associate Professor of Department of Radiation Diagnosis,
Radiotherapy and Medical Physics;
I. E. Tyurin
Russian Medical Academy of Postgraduate Education, Ministry of Health of the RF
Russian Federation
MD, PhD, DSc, Professor, Chief of Department
of Radiation Diagnosis, Radiotherapy and Medical Physics
Russian Federation
MD, PhD, DSc, Professor, Chief of Department
of Radiation Diagnosis, Radiotherapy and Medical Physics
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Review
For citations:
Mikhaylov A.I., Panov V.O., Tyurin I.E. Whole-body diffusion-weighted magnetic resonance imaging by estimating the measurable diffusion coefficient in Hodgkin lymphoma. Journal of radiology and nuclear medicine. 2015;(2):28-34. (In Russ.) https://doi.org/10.20862/0042-4676-2015-0-2-28-34
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