Clinical Significance of Diagnostic Images in Beta-Thalassemia
https://doi.org/10.20862/0042-4676-2025-106-6-226-234
Abstract
Thalassemias represent a heterogeneous group of autosomal recessive disorders resulting from reduced synthesis of alpha or beta hemoglobin chains causing structural abnormalities in red blood cells with their premature destruction accompanied by compensatory hyperplasia of bone marrow and extramedullary hematopoiesis. Frequent transfusions lead to iron overload affecting internal organs. The article presents a clinical case illustrating specific features of organ involvement and musculoskeletal system changes in a patient diagnosed with beta-thalassemia. Computed tomography revealed key findings including bone marrow hyperplasia, foci of extramedullary hematopoiesis, cardiomegaly as well as hepatomegaly with signs of hemosiderosis.
About the Authors
O. V. Teplyakova
Ural State Medical University;
Medical Association “New Hospital”
Russian Federation
Russian Federation
Olga V. Teplyakova, Dr. Med. Sc., Professor, Chair of Polyclinic Therapy; Head of Center for Clinical Rheumatology
ul. Repina, 3, Yekaterinburg, 620028
ul. Zavodskaya, 29, Yekaterinburg, 620109
E. Z. Eidlina
Medical Association “New Hospital”
Russian Federation
Russian Federation
Elena Z. Eidlina, Radiologist
ul. Zavodskaya, 29, Yekaterinburg, 620109
O. G. Tsvetkova
Medical Association “New Hospital”
Russian Federation
Russian Federation
Olga G. Tsvetkova, Rheumatologist
ul. Zavodskaya, 29, Yekaterinburg, 620109
A. А. Zhilyakov
Ural State Medical University
Russian Federation
Russian Federation
Alexandr А. Zhilyakov, Student, Institute of Clinical Medicine
ul. Repina, 3, Yekaterinburg, 620028
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Review
For citations:
Teplyakova O.V., Eidlina E.Z., Tsvetkova O.G., Zhilyakov A.А. Clinical Significance of Diagnostic Images in Beta-Thalassemia. Journal of radiology and nuclear medicine. 2025;106(6):226-234. (In Russ.) https://doi.org/10.20862/0042-4676-2025-106-6-226-234
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