Легочная цитотоксичность, индуцированная приемом блеомицина и метотрексата

Раннее выявление лекарственно-индуцированных поражений паренхимы легких часто бывает затруднено ввиду неспецифических клинико-рентгенологических проявлений. Обычно диагноз основывается на истории приема препарата, клинико-рентгенологической картине и исключении других причин поражения легочной ткани.

Чаще всего патологические изменения со стороны легких вызывают химиопрепараты. В целом приблизительно у 10% всех пациентов, получающих химиотерапию, развиваются патологи ческие изменения легочной паренхимы. Основными химиопрепаратами, вызывающими поражение легких, являются блеомицин, метотрексат, кармустин, бусульфан и циклофосфомид.

Из всех методов обследования компьютерная томография является самым чувствительным методом определения лекарственно-индуцированной патологии легочной паренхимы, собенностей распределения и динамики ее развития.

Приведены данные литературы и 2 клинических наблюдения поражения легких, индуцированного приемом блеомицина и метотрексата.

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