FLASH Radiotherapy: a Promising Direction in the Fight Against Cancer
https://doi.org/10.20862/0042-4676-2021-102-4-240-246
Abstract
At the present stage of scientific and technological progress, high-dose radiotherapy has become a common way to combat severe cancers. However, this treatment option is limited by normal tissues radiosensitivity. The developed technology of ultrashort pulse delivery of a dose of ionizing radiation to the zone of interest (FLASH radiotherapy) can achieve a high local control over tumor growth while sparing healthy tissues. This review summarizes the experimental findings supporting the possibility of transitioning to clinical studies of FLASH radiotherapy.
Supporting agencies: The article was fulfiled as part of the preparation of the State Task No. 37.8-2021 No. 121040200139-1 “Development of functional-adaptive radiosurgery of brain tumors by applying the method of functional diagnostics of areas of topical representation of skeletal muscles”.
About the Authors
А. V. Каrtashev
Granov Russian Research Center for Radiology and Surgical Technologies; Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
Artem V. Kartashev, Cand. Med. Sc., Radiotherapist, Senior Researcher, Department of Radiation and Combined Methods of Treatment; Associate Professor, Chair of Radiation Diagnostics and Radiation Therapy
ul. Leingradskaya, 70, Saint-Petersburg, 197758
ul. Kirochnaya, 41, Saint-Petersburg, 191015
Т. N. Bochkareva
Mechnikov North-Western State Medical University
Russian Federation
Russian Federation
Tatiana N. Bochkareva, Cand. Biol. Sc., Associate Professor, Chair of Radiation Diagnostics and Radiation Therapy
ul. Kirochnaya, 41, Saint-Petersburg, 191015
А. S. Anokhina
Granov Russian Research Center for Radiology and Surgical Technologies
Russian Federation
Russian Federation
Anastasia S. Anokhina, Radiotherapist, Department of Radiation and Combined Methods of Treatment
ul. Leingradskaya, 70, Saint-Petersburg, 197758
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Review
For citations:
Каrtashev А.V., Bochkareva Т.N., Anokhina А.S. FLASH Radiotherapy: a Promising Direction in the Fight Against Cancer. Journal of radiology and nuclear medicine. 2021;102(4):240-246. (In Russ.) https://doi.org/10.20862/0042-4676-2021-102-4-240-246
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