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MULTISLICE COMPUTED TOMOGRAPHY TO MEASURE VISCERAL FAT AREA IN PATIENT WITH ASTHMA AND OBESITY

https://doi.org/10.20862/0042-4676-2018-99-5-264-268

Abstract

Asthma and obesity prevalence in population have increased over the last years. In the Global Strategy for Asthma Management and Prevention (GINA, 2017) the “asthma-obesity” phenotype is identified, it has certain clinical features, disease course and response to therapy. One of the hypotheses explaining the relationship between asthma and obesity is the systemic inflammation theory. The visceral adipose tissue (VAT) plays a key role in this hypothesis, it produces various adipokines, imbalance of which results in the state of mild inflammation. With that only the body mass index (BMI) is used to diagnose obesity in asthma patients, but BMI doesn’t take into account the amount of VAT in the body.

The clinical case of a patient with asthma in combination with third degree of obesity is presented. Additionally the patient was given a multislice computed tomography to measure the visceral and subcutaneous fat areas, followed by an evaluation of the obtained data and a collation of the parameters with clinical and anthropometric characteristics.

About the Authors

N. S. Serova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation.
Russian Federation

ul. Trubetskaya, 8, stroenie 2, Moscow, 119991.

Corresponding Member of Russian Academy of Sciences, Dr. Med. Sc., Professor of Chair of Radiation Diagnosis and Radiotherapy.



N. V. Chichkova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation.
Russian Federation

ul. Trubetskaya, 8, stroenie 2, Moscow, 119991.

Dr. Med. Sc., Professor of Chair of Faculty Therapy № 1.



A. A. Gasparyan
I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation.
Russian Federation

ul. Trubetskaya, 8, stroenie 2, Moscow, 119991.

Postgraduate.



L. B. Kapanadze
I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation.
Russian Federation

ul. Trubetskaya, 8, stroenie 2, Moscow, 119991.

Assistant of Chair of Radiation Diagnosis and Radiotherapy.



V. V. Fomin
I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation.
Russian Federation

ul. Trubetskaya, 8, stroenie 2, Moscow, 119991.

Corresponding Member of Russian Academy of Sciences, Dr. Med. Sc., Professor, Chief of Chair of Faculty Therapy № 1.



References

1. Radchenko E.M., Slaba O.R. Asthma on a background of obesity and leptin of blood. Modern medicine: topical issues: Proceedings of the XVI International Research-to-Practice Conference. Novosibirsk: SibAK; 2013 (in Russ.)

2. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. 2017: 1–156.

3. https://ginasthma.org (дата обращения 12.06.2018) [Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2017: 1–156. Available at: https://ginasthma.org (accessed 12 June 2018) (in Russ.)]

4. Astaf’eva N.G., Gamova I.V., Udovichenko E.N., Perfilova I.A. Obesity and asthma. Lechashchiy Vrach (The Practitioner). 2014; 4: 8–10 (in Russ.)

5. Wood L.G., Garg M.L., Gibson P.G. A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma. J. Allergy Clin. Immunol. 2011; 127: 1133–40.

6. Hallstrand T.S., Fisher M.E., Wurfel M.M., Afari N., Buchwald D., Goldberg J. Genetic pleiotropy between asthma and obesity in a community based sample of twins. J. Allergy Clin. Immunol. 2005; 116: 1235–41.

7. Sideleva O., Suratt B.T., Black K.E., Tharp W.G., Pratley R.E., Forgione P. et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am. J. Respir. Crit. Care Med. 2012; 186 (7): 598–605.

8. Ignatova G.L., Makarova E.A. Asthma and obesity: clinical and pathophysiological aspects of new asthma phenotype assignment. Sovremennye Problemy Nauki i Obrazovaniya (Modern Problems of Science and Education). 2016; 4: 88 (in Russ.). Available at: http://www.science-education.ru/ru/article/view?id=25017 (accessed 13 June 2018)

9. Soloveva I.A., Sobko E.A., Demko I.V., Kraposhina A.Yu., Gordeeva N.V., Loktionova M.M. Asthma and obesity. Terapevticheskiy Arkhiv (Therapeutic Archive). 2017; 89 (3): 116–20 (in Russ.). DOI: 10.17116/terarkh2017893116-120

10. Obesity and overweight. Fact sheet of World Health Organization. 2017. Available at: http://www.int/ru/news-room/fact-sheets/detail/obesity-and-overweight (accessed 13 June 2018)

11. Cornier M.A., Despres J.P., Davis N., Grossniklaus D.A., Klein S., Lamarche B. et al. Assessing adiposity: a scientific statement from the American Heart Association. Circulation. 2011; 124: 1996–2019.

12. Suslyaeva N.M. Possibility radiological methods in diagnostics of visceral adiposity. Bulletin of Siberian Medicine. 2010; 5: 121–8 (in Russ.)

13. Bondarenko V.M., Marchuk V.P., Pimanov S.I., Mikhaylova N.A., Makarenko E.V. Correllation between the content of visceral fatty tissue by computed tomography findings with anthropometric measurements and the results of ultrasound investigation. Vestnik of Vitebsk State Medical University. 2013; 12 (1): 31–8 (in Russ.)

14. Shah R.V., Murthy V.L., Abbasi S.A., Blankstein R., Kwong R.Y., Goldfine A.B. et al. Visceral adiposity and the risk of metabolic syndrome across body mass index: the MESA Study. JACC Cardiovasc. Imaging. 2014; 7 (12): 1221–35.

15. Saito Y., Kobayashi J., Seimiya K., Hikita M., Takahashi K., Murano S. et al. Contribution of visceral fat accumulation to postprandial hyperlipidemia in human obesity. Eighth International Congress on Obesity. Int. J. Obes. 1998; 496: 226–8.


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For citations:


Serova N.S., Chichkova N.V., Gasparyan A.A., Kapanadze L.B., Fomin V.V. MULTISLICE COMPUTED TOMOGRAPHY TO MEASURE VISCERAL FAT AREA IN PATIENT WITH ASTHMA AND OBESITY. Journal of radiology and nuclear medicine. 2018;99(5):264-268. (In Russ.) https://doi.org/10.20862/0042-4676-2018-99-5-264-268

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ISSN 0042-4676 (Print)
ISSN 2619-0478 (Online)