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X-RAY SEMIOTICS OF ENDOCRINE OPHTHALMOPATHY. PART 2. THE OPTIC NERVE, LACRIMAL GLAND, SUPERIOR OPHTHALMIC VEIN

https://doi.org/10.20862/0042-4676-2016-97-6-325-332

Abstract

Objective: to study the optic nerve, lacrimal gland, and superior ophthalmic vein in patients with different clinical forms of endocrine ophthalmopathy (EOP). Material and methods. 294 patients (559 orbits) with EOP were examined. Hydrodynamic disorders were detected in 43 patients. 46 patients (91 orbits) with mixed or myogenic types of edematous exophthalmos (EE) were diagnosed as having optic neuropathy (ON). Results and discussion. The paper presents the indicators of the optic nerve, lacrimal gland, and superior ophthalmic vein in patients with different clinical forms of EOP. This study provides evidence that ON in patients with EOP is characterized by specific changes in the optic nerve, as shown by computed tomography. It is ascertained that there are volumetric and structural changes in the lacrimal gland in 40.62% of the patients with mixed EE and in 33.89% of those with myogenic EE. Conclusion. The study of the extraocular muscles in patients with ON-complicated EE may confirm that enlargement of the extraocular muscles at the orbital apex plays a major role in the pathogenesis of ON in this disease. The change in the anatomictopographic relationships of the orbit leads to compression of the superior ophthalmic vein, which entails obstruction of blood outflow from the orbit and causes ocular hypertension.

About the Authors

O. Yu. Yatsenko
Russian Medical Academy of Continuing Professional Education, Ministry of Health of the RF, ul. Barrikadnaya, 2/1, Moscow, 125993, Russian Federation
Russian Federation
MD, PhD, DSc, Associate Professor of Department of Ophthalmology


I. E. Tyurin
Russian Medical Academy of Continuing Professional Education, Ministry of Health of the RF, ul. Barrikadnaya, 2/1, Moscow, 125993, Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Chief of Department of Radiology


References

1. Chan L.L., Tan H.E., Fook-Chong S., Teo T.H., Lim L.H., Seah L.L. Graves ophthalmopathy: the bony orbit in optic neuropathy, its apical angular capacity, and impact on prediction of risk. Am. J. Neuroradiol. 2009; 30 (3): 597–602.

2. Bartalena L., Pinchera A., Marcocci C. Management of Graves' ophthalmopathy: reality and perspectives. Endocr. Rev. 2000; 21 (2): 168–99.

3. Brovkina A.F., Karmazanovskiy G.G., Yatsenko O.Yu., Moslekhi Sh. Optic nerve condition at the edematous exophthalmos complicated by optical neuropathy (computed tomography). Meditsinskaya Vizualizatsiya (Medical Visualization, Russian journal). 2008; 3: 74–7 (in Russ.).

4. Zakrzewski P.A., Weis E., White V.A., Rootman J. Intracellular extraocular muscle light-and heavy-chain deposition disease contributing to compressive optic neuropathy in a patient with preexisting Graves' orbitopathy. Ophthalmologica. 2010; 224: 59–62.

5. Kiljanski J., Nebes V., Stachura I., Kennerdell J.S., Wall J.R. Should Graves' disease be considered a collagen disorder of the thyroid, skeletal muscle and connective tissue? Horm. Metab. Res. 1995; 27 (12): 528–32.

6. Kahaly G.J. Imaging in thyroidassociated orbitopathy. Eur. J. Endocrinol. 2001; 145 (2): 112–3.

7. Regensburg N.I., Wiersinga W.M., Berendschot T.T., Saeed P., Mourits M.P. Densities of orbital fat and extraocular muscles in graves orbitopathy patients and controls. Ophthal. Plast. Reconstr. Surg. 2011; 27 (4): 236–40.

8. Goodall K.L., Jackson A., Leatherbarrow B., Whitehouse R.W. Enlargement of the tensor intermuscularis muscle in Graves’ophthalmopathy. A computed tomographic and magnetic resonance imaging study. Arch. Ophthalmol. 1995; 113 (10): 1286–9.

9. Liao S.L., Huang S.W. Correlation of retrobulbar volume change with resected orbital fat volume and proptosis reduction after fatty decompression for graves ophthalmopathy. Am. J. Ophthalmol. 2011; 151 (3): 465–9.

10. Gonc5 alves A.C., Silva L.N., Gebrim E.M., Monteiro M.L. Quantification of orbital apex crowding for screening of dysthyroid optic neuropathy using multide-tector CT. Am. J. Neuroradiol. 2012; 33 (8): 1602–7.

11. Brovkina A.F., Gusev G.A., Panteleeva O.G. Optic neuropathy at patients edematous exophthalmos. Klinicheskaya Oftal’mologiya (Clinical Ophthalmology, Russian journal). 2000; 2: 41–2 (in Russ.).

12. Yatsenko O.Yu. Space-topographical and structural changes in the soft tissue at the top of the orbit optic neuropathy at patients from edematous exophthalmos. Oftal’mologiya (Ophthalmology, Russian journal). 2014; 11 (2): 48–54 (in Russ.)

13. Panteleeva O.G. The modern concept of the mechanism of visual function disturbances in endocrine ophthalmopathy: Dr. Med. Sci. Thesises of Diss. Moscow; 2007 (in Russ.).

14. Breuer T., Ammann-Rauch D., Tasman A.J. Treatment of difficult endocrine orbitopathy cases. Laryngorhinootologie. 2007; 86 (5): 376–81.

15. Val’skiy V.V., Panteleeva O.G., Tishkova A.P., Berezhnova S.G. Clinic and tomographic signs of various forms of an thyroid eye disease. In: Proceedings of the scientific-practical conference “Diabetes mellitus and eye”. Moscow, Sept. 29–30, 2006. Moscow; 2006: 300–3 (in Russ.)

16. Likhvantseva V.G., Safonova T.N., Gontyurova O.A. Radiographic features of endocrine ophthalmopathy involving the lacrimal gland. Oftal’mologiya (Ophthalmology, Russian journal). 2012; 3: 61–4 (in Russ.).

17. Yatsenko O.Yu. Status of the lacrimal gland in patients with endocrine ophthalmopathy. Oftal’mologicheskie Vedomosti (Ophthalmic Statements, Russian journal). 2012; 2 (5): 15–9 (in Russ.).

18. Yatsenko O.Yu., Tyurin I.E. X-ray semiotics of endocrine ophthalmopathy. Part 1. Extraocular muscles and orbital cellular tissue. Vestnik Rentgenologii i Radiologii (Russian Journal of Radiology). 2016; 97 (3): 133–42 (in Russ.).


Review

For citations:


Yatsenko O.Yu., Tyurin I.E. X-RAY SEMIOTICS OF ENDOCRINE OPHTHALMOPATHY. PART 2. THE OPTIC NERVE, LACRIMAL GLAND, SUPERIOR OPHTHALMIC VEIN. Journal of radiology and nuclear medicine. 2016;97(6):325-332. (In Russ.) https://doi.org/10.20862/0042-4676-2016-97-6-325-332

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ISSN 0042-4676 (Print)
ISSN 2619-0478 (Online)