<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rentrad</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник рентгенологии и радиологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of radiology and nuclear medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0042-4676</issn><issn pub-type="epub">2619-0478</issn><publisher><publisher-name>Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20862/0042-4676-2024-105-4-194-201</article-id><article-id custom-type="elpub" pub-id-type="custom">rentrad-890</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Особенности оценки диффузионно-взвешенных изображений и результатов ASL-перфузии почек при остром повреждении почек</article-title><trans-title-group xml:lang="en"><trans-title>Features of Evaluating Renal Diffusion-Weighted Images and ASL-Perfusion Results in Acute Kidney Injury</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-0153-6040</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шкуратова</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shkuratov</surname><given-names>Yu. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шкуратова Юлия Юрьевна, аспирант кафедры лучевой диагностики и лучевой терапии с курсом дополнительного профессионального образования </p><p>ул. Крупской, 28, Смоленск, 214019</p></bio><bio xml:lang="en"><p>Yulia Yu. Shkuratova, Postgraduate, Chair of Radiation Diagnostics and Therapy with a Course of Additional Professional Education</p><p>ul. Krupskoy, 28, Smolensk, 214019</p></bio><email xlink:type="simple">juliyamilosh@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4983-5300</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>T. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозова Татьяна Геннадьевна, д. м. н., доцент, заведующая кафедрой лучевой диагностики и лучевой терапии c курсом дополнительного профессионального образования </p><p>ул. Крупской, 28, Смоленск, 214019</p></bio><bio xml:lang="en"><p>Tatiana G. Morozova, Dr. Med. Sc., Associate Professor, Chief of Chair of Radiation Diagnostics and Therapy with a Course of Additional Professional Education</p><p>ul. Krupskoy, 28, Smolensk, 214019</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Смоленский государственный медицинский университет» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Smolensk State Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>19</day><month>02</month><year>2025</year></pub-date><volume>105</volume><issue>4</issue><fpage>194</fpage><lpage>201</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шкуратова Ю.Ю., Морозова Т.Г., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шкуратова Ю.Ю., Морозова Т.Г.</copyright-holder><copyright-holder xml:lang="en">Shkuratov Y.Y., Morozova T.G.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.russianradiology.ru/jour/article/view/890">https://www.russianradiology.ru/jour/article/view/890</self-uri><abstract><sec><title>Цель</title><p>Цель: оценить особенности диффузионно-взвешенных изображений (ДВИ) и результатов перфузии почек с маркированием артериальных спинов (arterial spin labeling, ASL) при остром повреждении почек (ОПП).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В реанимационном отделении ОГБУЗ «Клиническая больница № 1» (г. Смоленск) с 2021 по 2024 гг. обследованы 58 пациентов с ОПП. Всем больным в течение 1–3 сут проводили магнитно-резонансную томографию почек с включением последовательностей ДВИ и ASL-перфузии, а также ультразвуковую допплерографию. Группа контроля была сформирована из 55 здоровых добровольцев с целью стандартизации полученных результатов.</p></sec><sec><title>Результаты</title><p>Результаты. Проведен анализ данных в сопоставлении с причинным фактором ОПП. Статистические результаты имели пороги отсечения, позволяющие прогнозировать причину ОПП, но требовался комплексный анализ количественного критерия ASL-перфузии почек, качественного и количественного критериев ДВИ (r=0,947). Показатели ASL-перфузии при всех этиологических причинах в сравнении с нормой были статистически значимы (r=0,995). Определение причинного фактора ОПП важно для тактики ведения пациента: при преренальной причине необходимо активное введение плазмозамещающих растворов, при ренальной – рестриктивная тактика инфузионной терапии. Увеличение показателей ASL-перфузии почек положительно сказывалось на клинико-лабораторной картине пациентов (r=0,903).</p></sec><sec><title>Заключение</title><p>Заключение. Особенностью совместного применения ДВИ и ASL-перфузии почек при ОПП является комплексная оценка качественного и количественного критериев по данным ДВИ и количественного – по данным ASL-перфузии. Комплексные результаты ДВИ и ASL-перфузии почек позволяют прогнозировать причину ОПП.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to evaluate the features of renal diffusion-weighted images (DWI) and arterial spin labeling (ASL) perfusion results in acute kidney injury (AKI).</p></sec><sec><title>Material and methods</title><p>Material and methods. In the intensive care unit of Clinical Hospital No. 1 (Smolensk), 58 AKI patients were examined from 2021 to 2024. All patients underwent renal magnetic resonance imaging for 1–3 days with the inclusion of DWI sequences and ASL perfusion as well as ultrasound dopplerography. The control group was formed from 55 healthy volunteers to standardize the obtained results.</p></sec><sec><title>Results</title><p>Results. The data were analyzed in comparison with AKI causal factor. The statistical results had cut-off thresholds that allowed predicting the cause of AKI, but a comprehensive analysis of the quantitative criterion of renal ASL perfusion, qualitative and quantitative criteria of DWI (r=0.947) was required. ASL perfusion indicators for all etiological causes were statistically significant in comparison with the normal ones (r=0.995). The determination of AKI causal factor was important for the subsequent management of patients: for a prerenal cause, active administration of plasma-substituting solutions, and for a renal one, restrictive infusion therapy tactics were needed. It was also noted that an increase in kidney ASL perfusion values had a positive effect on clinical and laboratory picture of AKI patients (r=0.903).</p></sec><sec><title>Conclusion</title><p>Conclusion. The feature of joint application of renal DWI and ASL perfusion in AKI is the comprehensive assessment of qualitative and quantitative criteria according to DWI data, and quantitative criterion according to ASL perfusion data. In assessing DWI, color mapping should be used. The complex results of renal DWI and ASL perfusion allow predicting AKI cause.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острое повреждение почек</kwd><kwd>ОПП</kwd><kwd>диффузионно-взвешенные изображения</kwd><kwd>ДВИ</kwd><kwd>ASL-перфузия</kwd><kwd>магнитно-резонансная томография</kwd><kwd>МРТ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute kidney injury</kwd><kwd>AKI</kwd><kwd>diffusion-weighted images</kwd><kwd>DWI</kwd><kwd>ASL-perfusion</kwd><kwd>magnetic resonance imaging</kwd><kwd>MRI</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012; 120(4): 179–84. https://doi.org/10.1159/000339789.</mixed-citation><mixed-citation xml:lang="en">Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012; 120(4): 179–84. https://doi.org/10.1159/000339789.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012; 2: 1–138. https://doi.org/10.1038/kisup.2012.3.</mixed-citation><mixed-citation xml:lang="en">KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012; 2: 1–138. https://doi.org/10.1038/kisup.2012.3</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Смирнов А.В., Каюков И.Г., Добронравов В.А., Румянцев А.Ш. Острое повреждение почек: концептуальные проблемы. Нефрология. 2014; 18(2): 8–24.</mixed-citation><mixed-citation xml:lang="en">Ostermann M. Acute kidney injury during critical illness – a global challenge. Messenger of Anesthesiology and Resuscitation. 2019; 16(2): 83–95 (in Russ).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Остерманн М. Острое повреждение почек у пациентов в критическом состоянии как общемировая проблема. Вестник анестезиологии и реаниматологии. 2019; 16(2): 83–95. https://doi.org/10.21292/2078-5658-2019-16-2-83-95.</mixed-citation><mixed-citation xml:lang="en">https://doi.org/10.21292/2078-5658-2019-16-2-83-95.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Морозов Ю.А., Марченко Т.В. Патофизиологические аспекты острого почечного повреждения. Почки. 2012; 2: 72–7.</mixed-citation><mixed-citation xml:lang="en">Morozov Yu.A., Marchenko T.V. Pathophysiological aspects of acute renal injury. Pochki / Kidneys. 2012; 2: 72–7 (in Russ).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ricci Z, Cruz D, Ronco C. The RIFLE classification for acute kidney injury definition. Kidney Int. 2008; 73(5): 538–46. https://doi.org/10.1038/sj.ki.5002743.</mixed-citation><mixed-citation xml:lang="en">Ricci Z, Cruz D, Ronco C. The RIFLE classification for acute kidney injury definition. Kidney Int. 2008; 73(5): 538–46. https://doi.org/10.1038/sj.ki.5002743.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cruz DN, Bagshaw SM, Ronco C, Ricci Z. Acute kidney injury: classification and staging. Contrib Nephrol. 2010; 164: 24–32. https://doi.org/10.1159/000313717.</mixed-citation><mixed-citation xml:lang="en">Cruz DN, Bagshaw SM, Ronco C, Ricci Z. Acute kidney injury: classification and staging. Contrib Nephrol. 2010; 164: 24–32. https://doi.org/10.1159/000313717.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Franklin SL, Bones IK, Harteveld AA, et al. Multi-organ comparison of flow-based arterial spin labeling techniques: spatially non-selective labeling for cerebral and renal perfusion imaging. Magn Reson Med. 2021; 85(5): 2580–94. https://doi.org/10.1002/mrm.28603.</mixed-citation><mixed-citation xml:lang="en">Franklin SL, Bones IK, Harteveld AA, et al. Multi-organ comparison of flow-based arterial spin labeling techniques: spatially non-selective labeling for cerebral and renal perfusion imaging. Magn Reson Med. 2021; 85(5): 2580–94. https://doi.org/10.1002/mrm.28603.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Труфанов Г.Е., Фокин В.А., Асатурян Е.Г. и др. Методика артериального спинового маркирования: клиническое применение. Russian Electronic Journal of Radiology. 2019; 9(4): 129–47. https://doi.org/10.21569/2222-7415-2019-9-4-129-147.</mixed-citation><mixed-citation xml:lang="en">Trufanov GE, Fokin VA, Asaturyan EG, et al. Arterial spin labeling: сlinical applications. Russian Electronic Journal of Radiology. 2019; 9(4): 129–47 (in Russ).  https://doi.org/10.21569/2222-7415-2019-9-4-129-147.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">De Perrot T, Sadjo Zoua C, Glessgen CG, et al. Diffusionweighted MRI in the genitourinary system. J Clin Med. 2022; 11(7): 1921. https://doi.org/10.3390/jcm11071921.</mixed-citation><mixed-citation xml:lang="en">De Perrot T, Sadjo Zoua C, Glessgen CG, et al. Diffusionweighted MRI in the genitourinary system. J Clin Med. 2022; 11(7): 1921. https://doi.org/10.3390/jcm11071921.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sugiyama K, Inoue T, Kozawa E, et al. Reduced oxygenation but not fibrosis defined by functional magnetic resonance imaging predicts the long-term progression of chronic kidney disease. Nephrol Dial Transplant. 2020; 35(6): 964–70. https://doi.org/10.1093/ndt/gfy324.</mixed-citation><mixed-citation xml:lang="en">Sugiyama K, Inoue T, Kozawa E, et al. Reduced oxygenation but not fibrosis defined by functional magnetic resonance imaging predicts the long-term progression of chronic kidney disease. Nephrol Dial Transplant. 2020; 35(6): 964–70. https://doi.org/10.1093/ndt/gfy324.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
