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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rentrad</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник рентгенологии и радиологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of radiology and nuclear medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0042-4676</issn><issn pub-type="epub">2619-0478</issn><publisher><publisher-name>Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20862/0042-4676-2024-105-3-170-180</article-id><article-id custom-type="elpub" pub-id-type="custom">rentrad-880</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Результаты применения различных методов реперфузии головного мозга у пациентов с острым ишемическим инсультом</article-title><trans-title-group xml:lang="en"><trans-title>Results of Using Different Brain Reperfusion Methods in Patients with Acute Ischemic Stroke</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-2036-6344</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хадисова</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Khadisova</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хадисова Амина Гаджиевна, аспирант кафедры лучевой диагностики</p><p>ул. Кирочная, 41, Санкт-Петербург, 191015</p></bio><bio xml:lang="en"><p>Amina G. Khadisova, Postgraduate, Chair of Radiation Diagnostics</p><p>ul. Kirochnaya, 41, Saint Petersburg, 191015</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8253-2382</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захматова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakhmatova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Захматова Татьяна Владимировна, д. м. н., доцент кафедры лучевой диагностики; доцент кафедры лучевой диагностики и медицинской визуализации c клиникой</p><p>ул. Кирочная, 41, Санкт-Петербург, 191015</p><p>ул. Аккуратова, 2, Санкт-Петербург, 197349</p></bio><bio xml:lang="en"><p>Tatiana V. Zakhmatova, Dr. Med. Sc., Associate Professor, Chair of Radiation Diagnostics; Associate Professor, Chair of Radiation Diagnostics and Medical Imaging with a Clinic</p><p>ul. Kirochnaya, 41, Saint Petersburg, 191015</p><p>ul. Akkuratova, 2, Saint Petersburg, 197349</p></bio><email xlink:type="simple">tvzakh@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2949-6268</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeeva</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергеева Татьяна Васильевна, к. м. н., доцент кафедры медицинской реабилитации и спортивной медицины; ассистент кафедры нейрохирургии и неврологии</p><p>ул. Литовская, 2Е, Санкт-Петербург, 194100</p><p>Университетская наб., 7-9, Санкт-Петербург, 199034</p></bio><bio xml:lang="en"><p>Tatyana V. Sergeeva, Cand. Med. Sc., Associate Professor, Chair of Medical Rehabilitation and Sports Medicine; Assistant Professor, Chair of Neurosurgery and Neurology</p><p>ul. Litovskaya, 2Е, Saint Petersburg, 194100</p><p>Universitetskaya naberezhnaya, 7-9, Saint Petersburg, 199034</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mechnikov North-Western State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России; ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mechnikov North-Western State Medical University; Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России; ФГБОУ ВО «Санкт-Петербургский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg State Pediatric Medical University; Saint Petersburg State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>09</day><month>10</month><year>2024</year></pub-date><volume>105</volume><issue>3</issue><fpage>170</fpage><lpage>180</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хадисова А.Г., Захматова Т.В., Сергеева Т.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Хадисова А.Г., Захматова Т.В., Сергеева Т.В.</copyright-holder><copyright-holder xml:lang="en">Khadisova A.G., Zakhmatova T.V., Sergeeva T.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.russianradiology.ru/jour/article/view/880">https://www.russianradiology.ru/jour/article/view/880</self-uri><abstract><p>Острый ишемический инсульт (ОИИ) занимает одно из ведущих мест в структуре инвалидности и смертности взрослого населения во всем мире, что обусловливает значительное социальное и экономическое бремя данной патологии. Последние достижения в диагностике и лечении ОИИ позволили существенно снизить летальность и улучшить функциональные исходы у пациентов. Однако сохраняются категории больных с неудовлетворительными результатами и осложнениями реперфузионной терапии, летальность в которых может превышать общий показатель. До настоящего времени остаются спорными аспекты определения показаний и выбора предпочтительного метода лечения церебральной реперфузии. В представленных клинических наблюдениях рассмотрены результаты применения тромболитической терапии и тромбоэкстракции у пациентов разных возрастных групп при ОИИ. Отмечено большое значение различных методов нейровизуализации (мультисрезовой компьютерной томографии, компьютерной ангиографии, ультразвукового дуплексного сканирования экстракраниальных и интракраниальных артерий) для своевременного установления диагноза и определения оптимальной тактики реваскуляризации.</p></abstract><trans-abstract xml:lang="en"><p>Acute ischemic stroke (AIS) occupies one of the leading places in the structure of disability and mortality in adult population throughout the world, which causes a significant social and economic burden of this pathology. Recent advances in AIS diagnosis and treatment have significantly reduced mortality and improved functional outcomes in patients. However, categories of patients with unsatisfactory results and complications of reperfusion therapy still remain. In some of them, mortality may exceed the overall rate. To this day, there are controversial aspects in determining indications and choosing the preferred method of cerebral reperfusion. The presented cases describe the results of using thrombolytic therapy and thromboextraction in AIS patients of different age groups. The importance of various neuroimaging methods (multislice computed tomography, computed angiography, duplex ultrasound of extra- and intracranial arteries) for timely diagnosis and determination of optimal revascularization tactics was noted.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый ишемический инсульт</kwd><kwd>ОИИ</kwd><kwd>тромболитическая терапия</kwd><kwd>тромбоэкстракция</kwd><kwd>мультисрезовая компьютерная томография</kwd><kwd>МСКТ</kwd><kwd>компьютерная ангиография</kwd><kwd>дуплексное сканирование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute ischemic stroke</kwd><kwd>AIS</kwd><kwd>thrombolytic therapy</kwd><kwd>thromboextraction</kwd><kwd>multislice computed tomography</kwd><kwd>MSCT</kwd><kwd>computed angiography</kwd><kwd>duplex ultrasound</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шамалов Н.А., Стаховская Л.В., Клочихина О.А. и др. Анализ динамики основных типов инсульта и патогенетических вариантов ишемического инсульта. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019; 119(3): 5–10. https://doi.org/10.17116/jnevro20191190325.</mixed-citation><mixed-citation xml:lang="en">Shamalov NA, Stakhovskaya LV, Klochikhina OA, et al. An analysis of the dynamics of the main types of stroke and pathogenetic variants of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2019; 119(3): 5–10 (in Russ). https://doi.org/10.17116/jnevro20191190325.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995; 333(24): 1581–7. https://doi.org/10.1056/NEJM199512143332401.</mixed-citation><mixed-citation xml:lang="en">The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995; 333(24): 1581–7. https://doi.org/10.1056/NEJM199512143332401.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hacke W, Kaste M, Fieschi C, еt al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA. 1995; 274(13): 1017–25.</mixed-citation><mixed-citation xml:lang="en">Hacke W, Kaste M, Fieschi C, еt al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA. 1995; 274(13): 1017–25.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hacke W, Kaste M, Fieschi C, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet. 1998; 352(9136): 1245–51. https://doi.org/10.1016/s0140-6736(98)08020-9.</mixed-citation><mixed-citation xml:lang="en">Hacke W, Kaste M, Fieschi C, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet. 1998; 352(9136): 1245–51. https://doi.org/10.1016/s0140-6736(98)08020-9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Clark WM, Wissman S, Albers GW, et al. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA. 1999; 282(21): 2019–26. https://doi.org/10.1001/jama.282.21.2019.</mixed-citation><mixed-citation xml:lang="en">Clark WM, Wissman S, Albers GW, et al. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA. 1999; 282(21): 2019–26. https://doi.org/10.1001/jama.282.21.2019.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sandercock P, Wardlaw JM, Lindley RI, et al. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. Lancet. 2012; 379(9834): 2352–63. https://doi.org/10.1016/S0140-6736(12)60768-5.</mixed-citation><mixed-citation xml:lang="en">Sandercock P, Wardlaw JM, Lindley RI, et al. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. Lancet. 2012; 379(9834): 2352–63. https://doi.org/10.1016/S0140-6736(12)60768-5.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008; 359(13): 1317–29. https://doi.org/10.1056/NEJMoa0804656.</mixed-citation><mixed-citation xml:lang="en">Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008; 359(13): 1317–29. https://doi.org/10.1056/NEJMoa0804656.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mateen FJ, Buchan AM, Hill MD. Outcomes of thrombolysis for acute ischemic stroke in octogenarians versus non agenarians. Stroke. 2010; 41(8): 1833–5. https://doi.org/10.1161/STROKEAHA.110.586438.</mixed-citation><mixed-citation xml:lang="en">Mateen FJ, Buchan AM, Hill MD. Outcomes of thrombolysis for acute ischemic stroke in octogenarians versus non agenarians. Stroke. 2010; 41(8): 1833–5. https://doi.org/10.1161/STROKEAHA.110.586438.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2019: 50(12): e344–418. https://doi.org/10.1161/STR.0000000000000211.</mixed-citation><mixed-citation xml:lang="en">Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2019: 50(12): e344–418. https://doi.org/10.1161/STR.0000000000000211.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lees KR, Bluhmki E, von Kummer R, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet. 2012; 375(9727): 1695–703. https://doi.org/10.1016/S0140-6736(10)60491-6.</mixed-citation><mixed-citation xml:lang="en">Lees KR, Bluhmki E, von Kummer R, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet. 2012; 375(9727): 1695–703. https://doi.org/10.1016/S0140-6736(10)60491-6.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Saver JL, Levine SR. Alteplase for ischaemic stroke-much sooner is much better. Lancet. 2010; 375(9727): 1667–8. https://doi.org/10.1016/S0140-6736(10)60634-4.</mixed-citation><mixed-citation xml:lang="en">Saver JL, Levine SR. Alteplase for ischaemic stroke-much sooner is much better. Lancet. 2010; 375(9727): 1667–8. https://doi.org/10.1016/S0140-6736(10)60634-4.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Hasan TF, Hasan H, Kelley RE. Overview of acute ischemic stroke evaluation and management. Biomedicines. 2021; 9(10): 1486. https://doi.org/10.3390/biomedicines9101486.</mixed-citation><mixed-citation xml:lang="en">Hasan TF, Hasan H, Kelley RE. Overview of acute ischemic stroke evaluation and management. Biomedicines. 2021; 9(10): 1486. https://doi.org/10.3390/biomedicines9101486.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hacke W, Donnan G, Fieschi C, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet. 2012; 363(9411): 768–74. https://doi.org/10.1016/S0140-6736(04)15692-4.</mixed-citation><mixed-citation xml:lang="en">Hacke W, Donnan G, Fieschi C, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet. 2012; 363(9411): 768–74. https://doi.org/10.1016/S0140-6736(04)15692-4.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Broderick JP, Palesch YY, Demchuk AM, et al. Endovascular therapy after Intravenous t-PA versus t-PA alone for stroke. N Engl J Med. 2013; 368(10): 893–903. https://doi.org/10.1056/NEJMoa1214300.</mixed-citation><mixed-citation xml:lang="en">Broderick JP, Palesch YY, Demchuk AM, et al. Endovascular therapy after Intravenous t-PA versus t-PA alone for stroke. N Engl J Med. 2013; 368(10): 893–903. https://doi.org/10.1056/NEJMoa1214300.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015; 372(11): 1019–30. https://doi.org/10.1056/NEJMoa1414905.</mixed-citation><mixed-citation xml:lang="en">Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015; 372(11): 1019–30. https://doi.org/10.1056/NEJMoa1414905.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016; 387(10029): 1723–31. https://doi.org/10.1016/S0140-6736(16)00163-X.</mixed-citation><mixed-citation xml:lang="en">Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016; 387(10029): 1723–31. https://doi.org/10.1016/S0140-6736(16)00163-X.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018; 378(1): 11–21. https://doi.org/10.1056/NEJMoa1706442.</mixed-citation><mixed-citation xml:lang="en">Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018; 378(1): 11–21. https://doi.org/10.1056/NEJMoa1706442.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
