rentradВестник рентгенологии и радиологииJournal of radiology and nuclear medicine0042-46762619-0478Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists10.20862/0042-4676-2024-105-2-87-92rentrad-870Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИCASE REPORTSПервичная диффузная крупноклеточная B-клеточная лимфома надпочечников как одна из редких причин паранеопластической полирадикулонейропатииPrimary Diffuse Large B-Cell Lymphoma of the Adrenal Glands: a Rare Cause of Paraneoplastic Neuropathyhttps://orcid.org/0000-0001-7251-093XШестаковД. В.ShestakovD. V.

ул. Гоголя, 40, Караганда, 100000

Dmitriy V. Shestakov, Resident Radiologist

ul. Gogolya, 40, Karaganda, 100000

dshestakov008@gmail.comПосметуховаК. А.PosmetukhovaК. A.

Посметухова Кристина Андреевна, врач-резидент рентгенолог 

ул. Гоголя, 40, Караганда, 100000

Кristina А. Posmetukhova, Resident Radiologist

ul. Gogolya, 40, Karaganda, 100000

АлиеваА. Т.ÄlievaÄ. Т.

Алиева Алия Тельманкызы, врач-резидент рентгенолог 

ул. Гоголя, 40, Караганда, 100000

Äliya Т. Älieva, Resident Radiologist

ul. Gogolya, 40, Karaganda, 100000

Некоммерческое акционерное общество «Медицинский университет Караганды»КазахстанKaraganda Medical UniversityKazakhstan20240710202410528792Copyright © Шестаков Д.В., Посметухова К.А., Алиева А.Т., 20242024Шестаков Д.В., Посметухова К.А., Алиева А.Т.Shestakov D.V., Posmetukhova К.A., Älieva Ä.Т.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.russianradiology.ru/jour/article/view/870

В статье представлен подробный анализ клинического наблюдения первичной диффузной крупноклеточной В-клеточной лимфомы надпочечников – редкого заболевания, которое поражает менее 1% пациентов с неходжкинскими лимфомами. Описан случай 46-летнего мужчины, госпитализированного с прогрессирующим параличом конечностей, который впоследствии был диагностирован как паранеопластическая полирадикулонейропатия, связанная с двусторонней лимфомой надпочечников. Обсуждаются сложности диагностики данной патологии, включая неоднозначные результаты визуализационных исследований и необходимость гистологической верификации для подтверждения диагноза. Основное внимание уделено уникальности клинических проявлений и значимости раннего распознавания симптомов для улучшения прогностических результатов при высокоагрессивных формах заболевания. Также подчеркнута необходимость междисциплинарного подхода в ведении таких пациентов с участием онкологов, эндокринологов и неврологов для оптимизации диагностического и терапевтического процессов. 

The article presents a detailed analysis of clinical observation of primary diffuse large B-cell lymphoma of the adrenal glands, a rare disease affecting less than 1% of patients with non-Hodgkin’s lymphomas. It describes the case of a 46-year-old man hospitalized with progressive limb paralysis, later diagnosed as paraneoplastic polyradiculoneuropathy associated with bilateral adrenal lymphoma. The diagnostic challenges of this pathology, including ambiguous imaging results and the need for histological verification to confirm the diagnosis are discussed. Special attention is paid to the uniqueness of clinical manifestations and the importance of early symptom recognition to improve prognostic outcomes in highly aggressive forms of the disease. The necessity of multidisciplinary approach in managing such patients with the participation of oncologists, endocrinologists, and neurologists to optimize diagnostic and therapeutic processes is also emphasized.

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The authors declare that there are no conflicts of interest present.