rentradВестник рентгенологии и радиологииJournal of radiology and nuclear medicine0042-46762619-0478Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists10.20862/0042-4676-2023-104-4-279-286rentrad-823Research ArticleЛЕКЦИИLЕCTURESДинамическая гепатохолесцинтиграфия с применением радиофармпрепарата Бромезида® 99mTcDynamic Hepatocholescintigraphy with Bromesida® 99mTchttps://orcid.org/0000-0002-8373-0505МироновС. П.MironovS. P.

Миронов Сергей Петрович, д. м. н., профессор, врач-радиолог лаборатории радиоизотопной диагностики и терапии отдела радионуклидной диагностики и позитронно-эмиссионной томографии

ул. Академика Чазова, 15а, Москва, 121552

Sergey P. Mironov, Dr. Med. Sc., Professor, Radiologist, Laboratory of Radioisotope Diagnostics and Therapy, Department of Radionuclide Diagnostics and Positron Emission Tomography

ul. Akademika Chazova, 15а, Moscow, 121552

https://orcid.org/0000-0002-0487-6902СергиенкоВ. Б.SergienkoV. B.

Сергиенко Владимир Борисович, д. м. н., профессор, руководитель отдела радионуклидной диагностики и позитронно-эмиссионнойтомографии

ул. Академика Чазова, 15а, Москва, 121552

Vladimir B. Sergienko, Dr. Med. Sc., Professor, Head of Department of Radionuclide Diagnostics and Positron Emission Tomography

ul. Akademika Chazova, 15а, Moscow, 121552

Научно-исследовательский институт клинической кардиологии им. А.Л. Мясникова ФГБУ «Национальный медицинский исследовательский центр кардиологии им. академика Е.И. Чазова» Минздрава РоссииРоссияMyasnikov Institute of Clinical Cardiology, Chyazov National Medical Research Center for CardiologyRussian Federation2023220120241044279286Copyright © Миронов С.П., Сергиенко В.Б., 20242024Миронов С.П., Сергиенко В.Б.Mironov S.P., Sergienko V.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.russianradiology.ru/jour/article/view/823

Сцинтиграфия печени и желчевыделительной системы с использованием радиофармпрепаратов (РФП), меченных короткоживущим технецием‑99m (99mТс), применяется с середины 1970-х гг. и сохраняет свое диагностическое значение до настоящего времени. В лекции уделено внимание ключевым аспектам фармакокинетики аналогов лидокаина, основанных на N-замещениях иминодиуксусной кислоты. Рассмотрена методология и диагностическая значимость гепатохолесцинтиграфии с применением препарата Бромезида® 99mТс (меброфенин), включающей непрерывную регистрацию пассажа РФП, анатомическую и функциональную характеристику печени, желчных протоков, желчного пузыря и двенадцатиперстной кишки. Обсуждается сцинтиграфическая семиотика при кистах общего желчного протока, остром и хроническом холецистите, дискинезии желчного пузыря и двенадцатиперстной кишки. Представленное клиническое наблюдение иллюстрирует возможности сцинтиграфии с РФП Бромезида® 99mТс при аномалии формы желчного пузыря.

Hepatobiliary scintigraphy using radiopharmaceuticals (RPh) labeled with short-lived technetium‑99m (99mТс) has been used since the mid‑1970s and still retains its diagnostic value. The lecture focuses on key aspects of the pharmacokinetics of lidocaine analogs based on N-substitutions of iminodiacetic acid. The methodology and diagnostic significance of hepatocholescintigraphy with Bromesida® 99mTс (mebrofenin), including computer registration of RPh passage, anatomical and functional characteristics of liver, bile ducts, gallbladder and duodenum, are considered. Scintigraphic semiotics in choledochal cysts, acute and chronic cholecystitis, gallbladder and duodenum dyskinesia, are discussed. The presented clinical case illustrates the possibilities of Bromesida® 99mTс scintigraphy in the gallbladder form anomaly.

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The authors declare that there are no conflicts of interest present.