rentradВестник рентгенологии и радиологииJournal of radiology and nuclear medicine0042-46762619-0478Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists10.20862/0042-4676-2021-102-4-240-246rentrad-658Research ArticleОБЗОРЫREVIEWSFLASH-терапия: перспективное направление в борьбе с опухольюFLASH Radiotherapy: a Promising Direction in the Fight Against Cancerhttps://orcid.org/0000-0002-6714-6413КарташевА. В.КаrtashevА. V.

Карташев Артем Владимирович, к. м. н., врач-радиотерапевт, ст. науч. сотр. отдела лучевых и комбинированных методов лечения; доцент кафедры лучевой диагностики и лучевой терапии

ул. Ленинградская, 70, пос. Песочный, Санкт-Петербург, 197758

ул. Кирочная, 41, Санкт-Петербург, 191015

Artem V. Kartashev, Cand. Med. Sc., Radiotherapist, Senior Researcher, Department of Radiation and Combined Methods of Treatment; Associate Professor, Chair of Radiation Diagnostics and Radiation Therapy 

ul. Leingradskaya, 70, Saint-Petersburg, 197758 

ul. Kirochnaya, 41, Saint-Petersburg, 191015 

https://orcid.org/0000-0002-6660-4806БочкареваТ. Н.BochkarevaТ. N.

Бочкарева Татьяна Николаевна, к. б. н., доцент кафедры лучевой диагностики и лучевой терапии

ул. Кирочная, 41, Санкт-Петербург, 191015

Tatiana N. Bochkareva, Cand. Biol. Sc., Associate Professor, Chair of Radiation Diagnostics and Radiation Therapy 

ul. Kirochnaya, 41, Saint-Petersburg, 191015 

https://orcid.org/0000-0002-8217-0462АнохинаА. С.AnokhinaА. S.

Анохина Анастасия Сергеевна, врач-радиотерапевт отдела лучевых и комбинированных методов лечения

ул. Ленинградская, 70, пос. Песочный, Санкт-Петербург, 197758 

Anastasia S. Anokhina, Radiotherapist, Department of Radiation and Combined Methods of Treatment 

ul. Leingradskaya, 70, Saint-Petersburg, 197758 

ФГБУ «Российский научный центр радиологии и хирургических технологий им. академика А.М. Гранова» Минздрава России; ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииРоссияGranov Russian Research Center for Radiology and Surgical Technologies; Mechnikov North-Western State Medical UniversityRussian FederationФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииРоссияMechnikov North-Western State Medical UniversityRussian FederationФГБУ «Российский научный центр радиологии и хирургических технологий им. академика А.М. Гранова» Минздрава РоссииРоссияGranov Russian Research Center for Radiology and Surgical TechnologiesRussian Federation2021150920211024240246Copyright © Карташев А.В., Бочкарева Т.Н., Анохина А.С., 20212021Карташев А.В., Бочкарева Т.Н., Анохина А.С.Каrtashev А.V., Bochkareva Т.N., Anokhina А.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.russianradiology.ru/jour/article/view/658

На современном этапе научно-технического прогресса высокодозная лучевая терапия стала распространенным средством борьбы с тяжелыми онкологическими заболеваниями. Однако данный метод лечения ограничен радиочувствительностью нормальных тканей. Разработанная технология ультракороткой импульсной доставки дозы ионизирующего излучения в зону интереса (FLASH-терапия, или импульсная лучевая радиотерапия) позволяет достичь высокого уровня местного контроля над ростом опухоли при щажении здоровых тканей. В настоящем обзоре обобщены полученные экспериментальные данные, обосновывающие возможность перехода к клиническим исследованиям FLASH-терапии.

At the present stage of scientific and technological progress, high-dose radiotherapy has become a common way to combat severe cancers. However, this treatment option is limited by normal tissues radiosensitivity. The developed technology of ultrashort pulse delivery of a dose of ionizing radiation to the zone of interest (FLASH radiotherapy) can achieve a high local control over tumor growth while sparing healthy tissues. This review summarizes the experimental findings supporting the possibility of transitioning to clinical studies of FLASH radiotherapy.

лучевая терапияFLASH-терапиязащита здоровых тканейобзорradiation therapyFLASH radiotherapyprotection of healthy tissuesreviewCтатья выполнена в рамках подготовки госзадания № 37.8-2021 № 121040200139-1 «Разработка функционально-адаптивной радиохирургии опухолей головного мозга путем применения методики функциональной диагностики зон топического представительства скелетных мышц».The article was fulfiled as part of the preparation of the State Task No. 37.8-2021 No. 121040200139-1 “Development of functional-adaptive radiosurgery of brain tumors by applying the method of functional diagnostics of areas of topical representation of skeletal muscles”.ReferencesFavaudon V, Caplier L, Monceau V, et al. Ultrahigh doserate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Sci Transl Med. 2014; 6(245): 245ra93. https://doi.org/10.1126/scitranslmed.3008973.Favaudon V, Caplier L, Monceau V, et al. 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The authors declare that there are no conflicts of interest present.