<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rentrad</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник рентгенологии и радиологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of radiology and nuclear medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0042-4676</issn><issn pub-type="epub">2619-0478</issn><publisher><publisher-name>Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20862/0042-4676-2021-102-3-183-195</article-id><article-id custom-type="elpub" pub-id-type="custom">rentrad-650</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>КТ-диагностика осложнений, возникающих при естественном течении и терапии COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>CT Diagnosis of Complications Arising from the Natural History and Treatment of COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2566-9881</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ядренцева</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yadrentseva</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ядренцева Светлана Владимировна, кандидат медицинских наук, врач-рентгенолог отделения лучевой диагностики ФГБУ «Клиническая больница № 1» Управления делами Президента Российской Федерации, врач-рентгенолог консультативного отдела ГБУЗ «Научно-практический клинический центр диагностики и телемедицинских технологий» Департамента здравоохранения г. Москвы</p><p>ул. Староволынская, 10, Москва, 121352, </p><p>ул. Средняя Калитниковская, 28, стр. 1, Москва, 109029</p></bio><bio xml:lang="en"><p>Svetlana V. Yadrentseva, Cand. Med. Sc., Radiologist, Radiology Department, Clinical Hospital No. 1, Office of the President of the Russian Federation; Radiologist, Advisory Department, Scientific and Practical Clinical Center for Diagnostics and Telemedicine Technologies</p><p>ul. Starovolynskaya, 10, Moscow, 121352,</p><p>ul. Srednyaya Kalitnikovskaya, 28 bld. 1, Moscow, 109029</p></bio><email xlink:type="simple">sv.yadrentseva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5994-0468</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нуднов</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nudnov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нуднов Николай Васильевич, доктор медицинских наук, профессор, заместитель директора по научной работе</p><p>ул. Профсоюзная, 86, стр. 1, Москва, 117997</p></bio><bio xml:lang="en"><p>Nikolay V. Nudnov, Dr. Med. Sc., Professor, Deputy Director for Research</p><p>ul. Profsoyuznaya, 86 bld. 1, Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6430-9590</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гасымов</surname><given-names>Э. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gasymov</surname><given-names>E. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гасымов Эмиль Гадирович, врач-ординатор</p><p>ул. Маршала Тимошенко, 19, стр. 1А, Москва, 121359</p></bio><bio xml:lang="en"><p>Emil’ G. Gasymov, Resident Physician</p><p>ul. Marshala Timoshenko, 19 bld. 1A, Moscow, 121359</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0531-7966</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пронькина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pron’kina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пронькина Елена Владимировна, врач-рентгенолог</p><p>пер. Сивцев Вражек, 26/28, Москва, 119002</p></bio><bio xml:lang="en"><p>Elena V. Pron’kina, Radiologist</p><p>pereulok Sivtsev Vrazhek, 26/28, Moscow, 119002</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Клиническая больница № 1» Управления делами Президента Российской Федерации;&#13;
ГБУЗ «Научно-практический клинический центр диагностики и телемедицинских технологий» Департамента здравоохранения г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Hospital No. 1, Office of the President of the Russian Federation;&#13;
Scientific and Practical Clinical Center for Diagnostics and Telemedicine Technologies</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Российский научный центр рентгенорадиологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Radiology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy, Office of the President of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУ «Поликлиника № 1» Управления делами Президента Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Polyclinic No. 1, Office of the President of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>23</day><month>07</month><year>2021</year></pub-date><volume>102</volume><issue>3</issue><fpage>183</fpage><lpage>195</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ядренцева С.В., Нуднов Н.В., Гасымов Э.Г., Пронькина Е.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Ядренцева С.В., Нуднов Н.В., Гасымов Э.Г., Пронькина Е.В.</copyright-holder><copyright-holder xml:lang="en">Yadrentseva S.V., Nudnov N.V., Gasymov E.G., Pron’kina E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.russianradiology.ru/jour/article/view/650">https://www.russianradiology.ru/jour/article/view/650</self-uri><abstract><p>Компьютерная томография при коронавирусной инфекции (COVID-19) эффективна не только в постановке диагноза, но и в своевременном и точном выявлении некоторых осложнений данного заболевания со стороны различных органов и систем. В статье показаны осложнения коронавирусной инфекции, с которыми может столкнуться на практике врач-рентгенолог. Они развиваются как при естественном течении, так и вследствие терапии COVID-19, включая геморрагические и тромботические осложнения при коагулопатии, пневмоторакс и пневмомедиастинум как следствие прямого цитотоксического действия SARS-CoV-2 на пневмоциты, баротравмы при искусственной вентиляции легких, а также патологические переломы ввиду остеопороза, в том числе стероидного, развившегося на фоне терапии глюкокортикостероидами. Рассмотрены основные причины, патогенез различных осложнений коронавирусной инфекции.</p></abstract><trans-abstract xml:lang="en"><p>Computed tomography for coronavirus infection (COVID-19) is effective not only in making a diagnosis, but also in timely and accurately detecting some complications of this disease in different organs and systems. The paper shows various complications of coronavirus infection that a radiologist may face in practice, which develop both in the natural course and due to therapy for COVID-19, including hemorrhagic and thrombotic events in coagulopathy, pneumothorax, and pneumomediastinum as a result of the direct cytotoxic effect of SARS-CoV-2 on pneumocytes, and barotrauma during mechanical ventilation, as well as pathological fractures due to osteoporosis, including steroid osteoporosis that has developed during therapy with glucocorticosteroids. It considers the main causes and pathogenesis of various complications of coronavirus infection.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>коронавирусная инфекция</kwd><kwd>COVID-19</kwd><kwd>компьютерная томография</kwd><kwd>тромбоэмболия легочной артерии</kwd><kwd>пневмоторакс</kwd><kwd>пневмомедиастинум</kwd><kwd>геморрагические осложнения</kwd><kwd>тромботические осложнения</kwd><kwd>обзор</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronavirus infection</kwd><kwd>COVID-19</kwd><kwd>computed tomography</kwd><kwd>pulmonary embolism</kwd><kwd>pneumothorax</kwd><kwd>pneumomediastinum</kwd><kwd>hemorrhagic events</kwd><kwd>thrombotic events</kwd><kwd>review</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Xu B, Xing Y, Peng J, et al. Chest CT for detecting COVID-19: a systematic review and meta-analysis of diagnostic accuracy. Eur Radiol. 2020; 30(10): 5720–7. https://doi.org/10.1007/s00330-020-06934-2.</mixed-citation><mixed-citation xml:lang="en">Xu B, Xing Y, Peng J, et al. Chest CT for detecting COVID-19: a systematic review and meta-analysis of diagnostic accuracy. Eur Radiol. 2020; 30(10): 5720–7. https://doi.org/10.1007/s00330-020-06934-2.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Винокуров А.С., Беленькая О.И., Золотова Е.А. и др. Дифференциальная диагностика двусторонних изменений легких на опыте стационара по приему внебольничных пневмоний – не только COVID-19. Медицинская визуализация. 2020; 24(2): 78–95. https://doi.org/10.24835/1607-0763-2020-2-78-95.</mixed-citation><mixed-citation xml:lang="en">Vinokurov AS, Belenkaya OI, Zolotova EA, et al. Differential diagnosis of bilateral lungs opacities in the hospital for admission of community-acquired pneumonia – not only COVID-19. Medical Visualization. 2020; 24(2): 78–95 (in Russ.). https://doi.org/10.24835/1607-0763-2020-2-78-95.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Баринов В.Е., Бояринцев В.В. Венозные тромботические осложнения как спутник новой короновирусной инфекции COVID-19. Кремлевская медицина. Клинический вестник. 2020; 2: 22–7. https://doi.org/10.26269/ayxs-2p77.</mixed-citation><mixed-citation xml:lang="en">Barinov VE, Boyarintsev VV. Venous thrombotic complications as a satellite of the new coronavirus infection COVID-19. Kremlin Medical Journal. 2020; 2: 22–7 (in Russ.). https://doi.org/10.26269/ayxs-2p77.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Li X, Ma X. Acute respiratory failure in COVID-19: is it “typical” ARDS? Crit Care. 2020; 24(1): 198. https://doi.org/10.1186/s13054-020-02911-9.</mixed-citation><mixed-citation xml:lang="en">Li X, Ma X. Acute respiratory failure in COVID-19: is it “typical” ARDS? Crit Care. 2020; 24(1): 198. https://doi.org/10.1186/s13054-020-02911-9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Колов И.А, Тюрин И.Н. Сердечно-сосудистые осложнения COVID-19. Вестник анестезиологии и реаниматологии. 2020; 17(4): 14–22. https://doi.org/10.21292/2078-5658-2020-17-4-14-22.</mixed-citation><mixed-citation xml:lang="en">Kozlov IA, Tyurin IN. Cardiovascular complications of COVID-19. Messenger of Anesthesiology and Resuscitation. 2020; 17(4): 14–22 (in Russ.). https://doi.org/10.21292/2078-5658-2020-17-4-14-22.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta A, Madhavan MV, Sehgal K, et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020; 26(7): 1017–32. https://doi.org/10.1038/s41591-020-0968-3.</mixed-citation><mixed-citation xml:lang="en">Gupta A, Madhavan MV, Sehgal K, et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020; 26(7): 1017–32. https://doi.org/10.1038/s41591-020-0968-3.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Klok FA, Kruip MJ, Meer NJ, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020; 191: 145–7. https://doi.org/10.1016/j.thromres.2020.04.013.</mixed-citation><mixed-citation xml:lang="en">Klok FA, Kruip MJ, Meer NJ, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020; 191: 145–7. https://doi.org/10.1016/j.thromres.2020.04.013.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Klok FA, Kruip MJ, Meer NJ, et al. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: an updated analysis. Thromb Res. 2020; 191: 148–50. https://doi.org/10.1016/j.thromres.2020.04.041.</mixed-citation><mixed-citation xml:lang="en">Klok FA, Kruip MJ, Meer NJ, et al. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: an updated analysis. Thromb Res. 2020; 191: 148–50. https://doi.org/10.1016/j.thromres.2020.04.041.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Haimei MA. Pathogenesis and treatment strategies of COVID-19-related hypercoagulant and thrombotic complications. Clin Appl Thromb Hemost. 2020; 26: 1076029620944497. https://doi.org/10.1177/1076029620944497.</mixed-citation><mixed-citation xml:lang="en">Haimei MA. Pathogenesis and treatment strategies of COVID-19-related hypercoagulant and thrombotic complications. Clin Appl Thromb Hemost. 2020; 26: 1076029620944497. https://doi.org/10.1177/1076029620944497.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Magrone T, Magrone M, Jirillo E. Focus on receptors for coronaviruses with special reference to angiotensin – converting enzyme 2 as a potential drug target – a perspective. Endocr Metab Immune Disord Drug Targets. 2020; 20(6): 807–11. https://doi.org/10.2174/1871530320666200427112902.</mixed-citation><mixed-citation xml:lang="en">Magrone T, Magrone M, Jirillo E. Focus on receptors for coronaviruses with special reference to angiotensin – converting enzyme 2 as a potential drug target – a perspective. Endocr Metab Immune Disord Drug Targets. 2020; 20(6): 807–11. https://doi.org/10.2174/1871530320666200427112902.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mogielnicki A, Kramkowski K, Hermanowicz JM, et al. Angiotensin-(1-9) enhances stasis-induced venous thrombosis in the rat because of the impairment of fibrinolysis. J Renin Angiotensin Aldosterone Syst. 2014; 15(1): 13–21. https://doi.org/10.1177/1470320313498631.</mixed-citation><mixed-citation xml:lang="en">Mogielnicki A, Kramkowski K, Hermanowicz JM, et al. Angiotensin-(1-9) enhances stasis-induced venous thrombosis in the rat because of the impairment of fibrinolysis. J Renin Angiotensin Aldosterone Syst. 2014; 15(1): 13–21. https://doi.org/10.1177/1470320313498631.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Chan NC, Weitz JI. COVID-19 coagulopathy, thrombosis, and bleeding. Blood. 2020; 136(4): 381–3. https://doi.org/10.1182/blood.2020007335.</mixed-citation><mixed-citation xml:lang="en">Chan NC, Weitz JI. COVID-19 coagulopathy, thrombosis, and bleeding. Blood. 2020; 136(4): 381–3. https://doi.org/10.1182/blood.2020007335.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med. 2020; 383(2):120–8. https://doi.org/10.1056/NEJMoa2015432.</mixed-citation><mixed-citation xml:lang="en">Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med. 2020; 383(2):120–8. https://doi.org/10.1056/NEJMoa2015432.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Gheblawi M, Wang K, Viveiros A, et al. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2. Circ Res. 2020; 126(10): 1456–74. https://doi.org/10.1161/CIRCRESAHA.120.317015.</mixed-citation><mixed-citation xml:lang="en">Gheblawi M, Wang K, Viveiros A, et al. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2. Circ Res. 2020; 126(10): 1456–74. https://doi.org/10.1161/CIRCRESAHA.120.317015.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bompard F, Monnier H, Saab I, et al. Pulmonary embolism in patients with COVID-19 pneumonia. Eur Respir J. 2020; 56(1): 2001365. https://doi.org/10.1183/13993003.01365-2020.</mixed-citation><mixed-citation xml:lang="en">Bompard F, Monnier H, Saab I, et al. Pulmonary embolism in patients with COVID-19 pneumonia. Eur Respir J. 2020; 56(1): 2001365. https://doi.org/10.1183/13993003.01365-2020.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Spyropoulos AC, Levy JH, Ageno W, et al. Scientific and standardization committee communication: clinical guidance on the diagnosis, prevention and treatment of venous thromboembolism in hospitalized patients with COVID-19. J Thromb Haemost. 2020; 18(8): 1859–65. https://doi.org/10.1111/jth.14929.</mixed-citation><mixed-citation xml:lang="en">Spyropoulos AC, Levy JH, Ageno W, et al. Scientific and standardization committee communication: clinical guidance on the diagnosis, prevention and treatment of venous thromboembolism in hospitalized patients with COVID-19. J Thromb Haemost. 2020; 18(8): 1859–65. https://doi.org/10.1111/jth.14929.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Yamakawa M, Kuno T, Mikami T, et al. Clinical characteristics of stroke with COVID-19: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis. 2020; 29(12): 105288. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105288.</mixed-citation><mixed-citation xml:lang="en">Yamakawa M, Kuno T, Mikami T, et al. Clinical characteristics of stroke with COVID-19: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis. 2020; 29(12): 105288. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105288.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Poissy J, Goutay J, Caplan M, et al. Pulmonary embolism in patients with COVID-19: awareness of an increased prevalence. Circulation. 2020; 142(2): 184–6. https://doi.org/10.1161/CIRCULATIONAHA.120.047430.</mixed-citation><mixed-citation xml:lang="en">Poissy J, Goutay J, Caplan M, et al. Pulmonary embolism in patients with COVID-19: awareness of an increased prevalence. Circulation. 2020; 142(2): 184–6. https://doi.org/10.1161/CIRCULATIONAHA.120.047430.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Pryce-Roberts A, Talaei M, Robertson NP. Neurological complications of COVID-19: a preliminary review. J Neurol. 2020; 267(6): 1870–13. https://doi.org/10.1007/s00415-020-09941-x.</mixed-citation><mixed-citation xml:lang="en">Pryce-Roberts A, Talaei M, Robertson NP. Neurological complications of COVID-19: a preliminary review. J Neurol. 2020; 267(6): 1870–13. https://doi.org/10.1007/s00415-020-09941-x.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Hanff TC, Mohareb AM, Giri J, et al. Thrombosis in COVID-19. Am J Hematol. 2020; 95(12): 1578–89. https://doi.org/10.1002/ajh.25982.</mixed-citation><mixed-citation xml:lang="en">Hanff TC, Mohareb AM, Giri J, et al. Thrombosis in COVID-19. Am J Hematol. 2020; 95(12): 1578–89. https://doi.org/10.1002/ajh.25982.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Mao L, Jin H, Wang M. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020; 77(6): 683–90. https://doi.org/10.1001/jamaneurol.2020.1127.</mixed-citation><mixed-citation xml:lang="en">Mao L, Jin H, Wang M. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020; 77(6): 683–90. https://doi.org/10.1001/jamaneurol.2020.1127.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Dorgalaleh A. Bleeding and bleeding risk in COVID-19. Semin Thromb Hemost. 2020; 46(7): 815–8. https://doi.org/10.1055/s-0040-1713434.</mixed-citation><mixed-citation xml:lang="en">Dorgalaleh A. Bleeding and bleeding risk in COVID-19. Semin Thromb Hemost. 2020; 46(7): 815–8. https://doi.org/10.1055/s-0040-1713434.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar A, Arora A, Sharma P, et al. Clinical features of COVID-19 and factors associated with severe clinical course: a systematic review and meta-analysis. SSRN. 2020; 3566166. https://doi.org/10.2139/ssrn.3566166.</mixed-citation><mixed-citation xml:lang="en">Kumar A, Arora A, Sharma P, et al. Clinical features of COVID-19 and factors associated with severe clinical course: a systematic review and meta-analysis. SSRN. 2020; 3566166. https://doi.org/10.2139/ssrn.3566166.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang B, Zhou X, Qiu Y, et al. Clinical characteristics of 82 cases of death with COVID-19. PLoS One. 2020; 15(7): e0235458. https://doi.org/10.1371/journal.pone.0235458.</mixed-citation><mixed-citation xml:lang="en">Zhang B, Zhou X, Qiu Y, et al. Clinical characteristics of 82 cases of death with COVID-19. PLoS One. 2020; 15(7): e0235458. https://doi.org/10.1371/journal.pone.0235458.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Liu X, Zhang X, Xiao Y, et al. Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatment. MedRxiv. 2020. https://doi.org/10.1101/2020.04.23.20076851.</mixed-citation><mixed-citation xml:lang="en">Liu X, Zhang X, Xiao Y, et al. Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatment. MedRxiv. 2020. https://doi.org/10.1101/2020.04.23.20076851.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020; 8(5): 475–81. https://doi.org/10.1016/S2213-2600(20)30079-5.</mixed-citation><mixed-citation xml:lang="en">Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020; 8(5): 475–81. https://doi.org/10.1016/S2213-2600(20)30079-5.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Nadkarni GN, Lala A, Bagiella E, et al. Anticoagulation, bleeding, mortality, and pathology in hospitalized patients with COVID-19. J Am Coll Cardiol. 2020; 76(16): 1815–26. https://doi.org/10.1016/j.jacc.2020.08.041.</mixed-citation><mixed-citation xml:lang="en">Nadkarni GN, Lala A, Bagiella E, et al. Anticoagulation, bleeding, mortality, and pathology in hospitalized patients with COVID-19. J Am Coll Cardiol. 2020; 76(16): 1815–26. https://doi.org/10.1016/j.jacc.2020.08.041.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Quincho-Lopez A, Quincho-Lopez DL, Hurtado-Medina FD. Case report: pneumothorax and pneumomediastinum as uncommon complications of COVID-19 pneumonia-literature review. Am J Trop Med Hyg. 2020; 103(3): 1170–6. https://doi.org/10.4269/ajtmh.20-0815.</mixed-citation><mixed-citation xml:lang="en">Quincho-Lopez A, Quincho-Lopez DL, Hurtado-Medina FD. Case report: pneumothorax and pneumomediastinum as uncommon complications of COVID-19 pneumonia-literature review. Am J Trop Med Hyg. 2020; 103(3): 1170–6. https://doi.org/10.4269/ajtmh.20-0815.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Михеев А.В., Афтаева Е.В., Казакова С.С. и др. Спонтанный пневмоторакс как осложнение поражения легких при COVID-19. Туберкулез и болезни легких. 2021; 99(3): 18–22. https://doi.org/10.21292/2075-1230-2021-99-3-18-22.</mixed-citation><mixed-citation xml:lang="en">Mikheev AV, Аftаevа EV, Kаzаkovа SS, et al. Spontaneous pneumothorax as a complication of lung injury due to COVID-19. Tuberculosis and Lung Diseases. 2021; 99(3): 18–22 (in Russ.). https://doi.org/10.21292/2075-1230-2021-99-3-18-22.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Diaz R, Heller D. Barotrauma and mechanical ventilation. Treasure Island (FL): StatPearls Publishing; 2021.</mixed-citation><mixed-citation xml:lang="en">Diaz R, Heller D. Barotrauma and mechanical ventilation. Treasure Island (FL): StatPearls Publishing; 2021.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kolani S, Houari N, Haloua M, et al. Spontaneous pneumomediastinum occurring in the SARS-COV-2 infection. IDCases. 2020; 21: e00806. https://doi.org/10.1016/j.idcr.2020.e00806.</mixed-citation><mixed-citation xml:lang="en">Kolani S, Houari N, Haloua M, et al. Spontaneous pneumomediastinum occurring in the SARS-COV-2 infection. IDCases. 2020; 21: e00806. https://doi.org/10.1016/j.idcr.2020.e00806.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">McGuinness G, Zhan C, Rosenberg N, et al. Increased incidence of barotrauma in patients with COVID-19 on invasive mechanical ventilation. Radiology. 2020; 297(2): 252–62. https://doi.org/10.1148/radiol.2020202352.</mixed-citation><mixed-citation xml:lang="en">McGuinness G, Zhan C, Rosenberg N, et al. Increased incidence of barotrauma in patients with COVID-19 on invasive mechanical ventilation. Radiology. 2020; 297(2): 252–62. https://doi.org/10.1148/radiol.2020202352.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Lemmers DH, Hilal MA, Bna C, et al. Pneumomediastinum and subcutaneous emphysema in COVID-19: barotrauma or lung frailty? ERJ Open Res. 2020; 6(4): 00385-2020. https://doi.org/10.1183/23120541.003852020.</mixed-citation><mixed-citation xml:lang="en">Lemmers DH, Hilal MA, Bna C, et al. Pneumomediastinum and subcutaneous emphysema in COVID-19: barotrauma or lung frailty? ERJ Open Res. 2020; 6(4): 00385-2020. https://doi.org/10.1183/23120541.003852020.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Yu EW, Tsourdi E, Clarke BL, et al. Osteoporosis management in the era of COVID-19. J Bone Miner Res. 2020; 35(6): 1009–13. https://doi.org/10.1002/jbmr.4049.</mixed-citation><mixed-citation xml:lang="en">Yu EW, Tsourdi E, Clarke BL, et al. Osteoporosis management in the era of COVID-19. J Bone Miner Res. 2020; 35(6): 1009–13. https://doi.org/10.1002/jbmr.4049.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Tramontana F, Napoli N, Fuleihan GE, Strollo R. The D-side of COVID-19: musculoskeletal benefits of vitamin D and beyond. Endocrine. 2020; 69(2): 237–40. https://doi.org/10.1007/s12020-020-02407-0.</mixed-citation><mixed-citation xml:lang="en">Tramontana F, Napoli N, Fuleihan GE, Strollo R. The D-side of COVID-19: musculoskeletal benefits of vitamin D and beyond. Endocrine. 2020; 69(2): 237–40. https://doi.org/10.1007/s12020-020-02407-0.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kortebein P, Ferrando A, Lombeida J, et al. Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA. 2007; 297(16): 1772–4. https://doi.org/10.1001/jama.297.16.1772-b.</mixed-citation><mixed-citation xml:lang="en">Kortebein P, Ferrando A, Lombeida J, et al. Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA. 2007; 297(16): 1772–4. https://doi.org/10.1001/jama.297.16.1772-b.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Nakashima T, Takayanagi H. Osteoimmunology: crosstalk between the immune and bone systems. J Clin Immunol. 2009; 29(5): 555–67. https://doi.org/10.1007/s10875-009-9316-6.</mixed-citation><mixed-citation xml:lang="en">Nakashima T, Takayanagi H. Osteoimmunology: crosstalk between the immune and bone systems. J Clin Immunol. 2009; 29(5): 555–67. https://doi.org/10.1007/s10875-009-9316-6.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Mikulska M, Nicolini LA, Signori A, et al. Tocilizumab and steroid treatment in patients with COVID-19 pneumonia. PLoS One. 2020; 15(8): e0237831. https://doi.org/10.1371/journal.pone.0237831.</mixed-citation><mixed-citation xml:lang="en">Mikulska M, Nicolini LA, Signori A, et al. Tocilizumab and steroid treatment in patients with COVID-19 pneumonia. PLoS One. 2020; 15(8): e0237831. https://doi.org/10.1371/journal.pone.0237831.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Jean SS, Lee PI, Hsueh PR. Treatment options for COVID-19: the reality and challenges. J Microbiol Immunol Infect. 2020; 53(3): 436–43. https://doi.org/10.1016/j.jmii.2020.03.034.</mixed-citation><mixed-citation xml:lang="en">Jean SS, Lee PI, Hsueh PR. Treatment options for COVID-19: the reality and challenges. J Microbiol Immunol Infect. 2020; 53(3): 436–43. https://doi.org/10.1016/j.jmii.2020.03.034.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Lane NE, Yao W, Balooch M, et al. Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebotreated or estrogen-deficient mice. J Bone Miner Res. 2006; 21(3): 466–76. https://doi.org/10.1359/JBMR.051103.</mixed-citation><mixed-citation xml:lang="en">Lane NE, Yao W, Balooch M, et al. Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebotreated or estrogen-deficient mice. J Bone Miner Res. 2006; 21(3): 466–76. https://doi.org/10.1359/JBMR.051103.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
