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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rentrad</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник рентгенологии и радиологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of radiology and nuclear medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0042-4676</issn><issn pub-type="epub">2619-0478</issn><publisher><publisher-name>Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20862/0042-4676-2020-101-6-358-368</article-id><article-id custom-type="elpub" pub-id-type="custom">rentrad-601</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Дифференциальная диагностика впервые выявленных в легких изменений по типу «матового стекла» в период пандемии COVID-19: случай из клинической практики</article-title><trans-title-group xml:lang="en"><trans-title>Differential Diagnosis of New-Onset Pulmonary Ground Glass Changes During the COVID-19 Pandemic: a Case Report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9337-3903</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпина</surname><given-names>Н. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpina</surname><given-names>N. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпина Наталья Леонидовна, д. м. н., руководитель Центра диагностики и реабилитации заболеваний органов дыхания, зам. директора</p><p>ул. Яузская аллея, 2, Москва, 107564</p></bio><bio xml:lang="en"><p>Natalya L. Karpina, Dr. Med. Sc., Head of the Center for Diagnostics and Rehabilitation of Respiratory Diseases, Deputy Director</p><p>ul. Yauzskaya Alleya, 2, Moscow, 107564</p></bio><email xlink:type="simple">natalya-karpina@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8170-3300</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сивокозов</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sivokozov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сивокозов Илья Владимирович, к. м. н., науч. сотр., заведующий отделением эндоскопии Центра диагностики и реабилитации заболеваний органов дыхания</p><p>ул. Яузская аллея, 2, Москва, 107564</p></bio><bio xml:lang="en"><p>Ilya V. Sivokozov, Cand. Med. Sc., Researcher, Head of Endoscopy Department, Center for Diagnostics and Rehabilitation of Respiratory Diseases</p><p>ul. Yauzskaya Alleya, 2, Moscow, 107564</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5385-1808</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабалина</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabalina</surname><given-names>I. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шабалина Ирина Юрьевна, к. м. н., ст. науч. сотр. Центра диагностики и реабилитации заболеваний органов дыхания</p><p>ул. Яузская аллея, 2, Москва, 107564</p></bio><bio xml:lang="en"><p>Irina Yu. Shabalina, Cand. Med. Sc., Senior Researcher, Center for Diagnostics and Rehabilitation of Respiratory Diseases</p><p>ul. Yauzskaya Alleya, 2, Moscow, 107564</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1782-7763</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Semenova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Семенова Людмила Алексеевна, к. м. н., ст. науч. сотр. отдела патоморфологии клеточной биологии и биохимии</p><p>ул. Яузская аллея, 2, Москва, 107564</p></bio><bio xml:lang="en"><p>Lyudmila А. Semenova, Cand. Med. Sc., Senior Researcher, Department of Pathomorphology Cell Biology and Biochemistry</p><p>ul. Yauzskaya Alleya, 2, Moscow, 107564</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7800-8158</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Асанов</surname><given-names>Р. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Asanov</surname><given-names>R. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Асанов Руслан Баймурадович, лаборант-исследователь Центра диагностики и реабилитации заболеваний органов дыхания</p><p>ул. Яузская аллея, 2, Москва, 107564</p></bio><bio xml:lang="en"><p>Ruslan B. Asanov, Laboratory Researcher, Center for Diagnostics and Rehabilitation of Respiratory Diseases</p><p>ul. Yauzskaya Alleya, 2, Moscow, 107564</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5267-7193</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борисова</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Borisova</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Борисова Анастасия Юрьевна, врач-рентгенолог отделения лучевой диагностики Центра диагностики и реабилитации заболеваний органов дыхания</p><p>ул. Яузская аллея, 2, Москва, 107564</p></bio><bio xml:lang="en"><p>Аnastasiya Yu. Borisova, Radiologist, Radiology Department</p><p>ul. Yauzskaya Alleya, 2, Moscow, 107564</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0589-566X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егорова Анна Дмитриевна, мл. науч. сотр. Центра диагностики и реабилитации заболеваний органов дыхания</p><p>ул. Яузская аллея, 2, Москва, 107564</p></bio><bio xml:lang="en"><p>Аnastasiya Yu. Borisova, Junior Researcher, Center for Diagnostics and Rehabilitation of Respiratory Diseases</p><p>ul. Yauzskaya Alleya, 2, Moscow, 107564</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Центральный научно-исследовательский институт туберкулеза»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Research Institute of Tuberculosis</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>25</day><month>01</month><year>2021</year></pub-date><volume>101</volume><issue>6</issue><fpage>358</fpage><lpage>368</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карпина Н.Л., Сивокозов И.В., Шабалина И.В., Семенова Л.А., Асанов Р.Б., Борисова А.Ю., Егорова А.Д., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Карпина Н.Л., Сивокозов И.В., Шабалина И.В., Семенова Л.А., Асанов Р.Б., Борисова А.Ю., Егорова А.Д.</copyright-holder><copyright-holder xml:lang="en">Karpina N.L., Sivokozov I.V., Shabalina I.Y., Semenova L.A., Asanov R.B., Borisova A.Y., Egorova A.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.russianradiology.ru/jour/article/view/601">https://www.russianradiology.ru/jour/article/view/601</self-uri><abstract><p>Представлен клинический случай диагностики гиперсенситивного пневмонита у пациента молодого возраста в период пандемии COVID-19, когда при наличии жалоб на одышку и интерстициальных изменений в легких по типу «матового стекла» первично был установлен однозначный диагноз: вирусная COVID-ассоциированная двусторонняя пневмония. При проведении компьютерной томографии основными проявлениями в легких у больного были инфильтративно-воспалительные изменения в виде многочисленных участков преимущественно интерстициальной инфильтрации (по типу «матового стекла») с наличием участков консолидации и ретикулярными изменениями различной протяженности периферической локализации, преимущественно в нижних долях легких с вовлечением паренхимы правого легкого до 25–50%, левого легкого – до 25–50%. Диагноз «гиперсенситивный пневмонит» был подтвержден при цитогистологическом исследовании биопсийного материала, полученного при бронхоскопии с комплексом биопсий и эндобронхиальной криобиопсией слизистой бронха.Данное клиническое наблюдение демонстрирует, что обнаружение при компьютерной томографии органов грудной клетки в легких изменений по типу «матового стекла» является поводом для дальнейшего обследования пациента и требует морфологической верификации диагноза, так как цена диагностической ошибки – жизнь пациента.</p></abstract><trans-abstract xml:lang="en"><p>The paper describes a clinical case of hypersensitivity pneumonitis in a young patient during the COVID-19 pandemic when the patient having complaints of dyspnea and interstitial lung changes as ground glass opacity was initially unambiguously diagnosed with viral COVID-related bilateral pneumonia. The chief computed tomography manifestations in the lung were infiltrative inflammatory changes as numerous areas of predominantly interstitial infiltration by the type of ground glass, with consolidation areas and reticular changes, varying in extent, peripheral localization, mainly in the lower lobes and with the 25–50% involvement of the right and left lung parenchyma. The diagnosis of hypersensitivity pneumonitis was confirmed by cytological and histological examinations of the biopsy material obtained during bronchoscopy using a set of biopsies and endobronchial cryobiopsy.This clinical case demonstrates that the chest computed tomography detection of pulmonary ground glasstype changes is a reason for further patient examinations and requires morphological verification of the diagnosis, since the cost of a diagnostic error is the life of a patient.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дифференциальная диагностика</kwd><kwd>гиперсенситивный пневмонит</kwd><kwd>новая коронавирусная инфекция</kwd><kwd>«матовое стекло»</kwd></kwd-group><kwd-group xml:lang="en"><kwd>differential diagnostics</kwd><kwd>hypersensitivity pneumonitis</kwd><kwd>new coronavirus infection</kwd><kwd>ground glass</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Временные методические рекомендации. 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