rentradВестник рентгенологии и радиологииJournal of radiology and nuclear medicine0042-46762619-0478Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists10.20862/0042-4676-2019-100-6-379-386rentrad-520Research ArticleОБЗОРЫREVIEWSДиффузионно-взвешенная магнитно-резонансная томография в диагностике и стадировании рака мочевого пузыряDiffusion-Weighted Magnetic Resonance Imaging in the Diagnosis and Staging of Bladder Cancerhttps://orcid.org/0000-0001-5227-006XФроловаИ. Г.FrolovaI. G.

Фролова Ирина Георгиевна,д. м. н., профессор, заведующая отделением лучевой диагностики

Кооперативный пер., 5, Томск, 634009

Irina G. Frolova, Dr. Med. Sc., Professor, Head of Department of Radiology

 Kooperativnyy pereulok, 5, Tomsk, 634009

https://orcid.org/0000-0003-3187-3659ГригорьевЕ. Г.Grigor'evE. G.

Григорьев Евгений Геннадьевич*, к. м. н., ст. науч. сотр.

Кооперативный пер., 5, Томск, 634009

Evgeniy G. Grigor'ev, Cand. Med. Sc., Senior Researcher

Kooperativnyy pereulok, 5, Tomsk, 634009

adresprostoy@gmail.comВеличкоС. А.VelichkoS. A.

Величко Светлана Андреевна,д. м. н., вед. науч. сотр.

Кооперативный пер., 5, Томск, 634009

Svetlana A. Velichko, Dr. Med. Sc., Leading Researcher

Kooperativnyy pereulok, 5, Tomsk, 634009

УсоваА. В.UsovaA. V.

Усова Анна Владимировна, к. м. н., ст. науч. сотр.

Кооперативный пер., 5, Томск, 634009

Anna V. Usova, Cand. Med. Sc., Senior Researcher

Kooperativnyy pereulok, 5, Tomsk, 634009

https://orcid.org/0000-0001-8114-2200ТрухачеваН. Г.TrukhachevaN. G.

Трухачева Наталья Геннадьевна, к. м. н., ст. науч. сотр.

Кооперативный пер., 5, Томск, 634009

Natal'ya G. Trukhacheva, Cand. Med. Sc., Senior Researcher

Kooperativnyy pereulok, 5, Tomsk, 634009

Научно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»РоссияCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of SciencesRussian Federation2019260120201006379386Copyright © Фролова И.Г., Григорьев Е.Г., Величко С.А., Усова А.В., Трухачева Н.Г., 20202020Фролова И.Г., Григорьев Е.Г., Величко С.А., Усова А.В., Трухачева Н.Г.Frolova I.G., Grigor'ev E.G., Velichko S.A., Usova A.V., Trukhacheva N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.russianradiology.ru/jour/article/view/520

Представлена оценка современных диагностических возможностей применения диффузионно-взвешенных изображений (ДВИ) в протоколе магнитно-резонансной томографии при раке мочевого пузыря. Актуализировано применение данной импульсной последовательности в рамках мультипараметрического МР-исследования как одной из функциональных методик. Описаны возможности ДВИ при изолированном использовании и при совмещении с Т2-взвешенными изображениями в визуализации опухоли, послеоперационных изменений и сопутствующей патологии. Приведены дифференциальнодиагностические критерии для определения степени инвазии опухоли, в том числе с оценкой точности по данным измеряемого коэффициента диффузии.

Источниками обзорного исследования являлись публикации, включенные в рецензируемые базы PubMed, Scopus, eLIBRARY, открытые источники Google Scholar, Researchgate. 

This scientific review assesses the current diagnostic capabilities of diffusion-weighted images used in the magnetic resonance imaging protocol for bladder cancer. It actualizes this impulse sequence employed within the framework of a multiparametric MRI study as one of the functional techniques. The review deals with the possibilities of diffusion-weighted images used in an independent version and in combination with T2-weighted images to visualize a tumor, postoperative changes, and associated pathology. It gives differential diagnostic criteria in identifying the extent of tumor invasion, including that with accuracy assessment according to the measured diffusion coefficient.

The sources of the review are publications included in the peer-reviewed databases PubMed, Scopus, eLIBRARY and the open sources Google Scholar, Researchgate. 

рак мочевого пузырямультипараметрическая магнитно-резонансная томографиядиффузионно-взвешенные изображенияизмеряемый коэффициент диффузиистадированиеобзор литературыbladder cancermultiparametric magnetic resonance imagingdiffusion-weighted imagesmeasured diffusion coefficientstagingliterature reviewReferencesКаприн А.Д., Старинский В.В., Петрова Г.В. (ред.). Злокачественные новообразования вРоссии в2016 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена; 2018. http://www.oncology.ru/service/statistics/ (дата обращения 14.09.2018).Kaprin A.D., Starinskiy V.V., Petrova G.V. (Eds) Malignant neoplasms in Russia in 2016 (morbidity and mortality). Moscow; 2018 (in Russ.). Available at: http://www.oncology.ru/ service/statistics/ (accessed 14.09.2018).]Mahdavifar N., Ghoncheh M., Pakzad R., Momenimovahed Z., Salehiniya H. Epidemiology, incidence and mortality of bladder cancer and their relationship with the development index in the world. Asian Pacific J. Canc. Preven.2016; 17 (1): 381–6. DOI: 10.7314/apjcp.2016.17.1.381Mahdavifar N., Ghoncheh M., Pakzad R., Momenimovahed Z., Salehiniya H. Epidemiology, incidence and mortality of bladder cancer and their relationship with the development index in the world. Asian Pacific J. Canc. Preven.2016; 17 (1): 381–6. DOI: 10.7314/apjcp.2016.17.1.381Bostrom P.J., van Rhijn B.W.G., Fleshner N., Finelli A., Jewett M., Thoms J. et al. Staging and staging errors in bladder cancer. Eur. Urol. Suppl. [Internet]. 2010; 9 (1): 2–9. DOI: 10.1016/j.eursup.2010.01.005Bostrom P.J., van Rhijn B.W.G., Fleshner N., Finelli A., Jewett M., Thoms J. et al. Staging and staging errors in bladder cancer. Eur. Urol. Suppl. [Internet]. 2010; 9 (1): 2–9. DOI: 10.1016/j.eursup.2010.01.005Aarsæther E., Patel H.R. Contemplating bladder cancer care: can we cut costs and improve quality of care? Exp. Rev. Antican. Ther. [Internet]. 2013; 13 (6): 639–40. DOI: 10.1586/era.13.29Aarsæther E., Patel H.R. Contemplating bladder cancer care: can we cut costs and improve quality of care? Exp. Rev. Antican. Ther. [Internet]. 2013; 13 (6): 639–40. DOI: 10.1586/era.13.29Babjuk M., Böhle A., Burger M., Capoun O., Cohen D., Compérat E.M. et al. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2016. Eur. Urol. [Internet]. 2017; 71 (3): 447–61. DOI: 10.1016/j.eururo. 2016.05.041Babjuk M., Böhle A., Burger M., Capoun O., Cohen D., Compérat E.M. et al. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2016. Eur. Urol. [Internet]. 2017; 71 (3): 447–61. DOI: 10.1016/j.eururo. 2016.05.041Alfred Witjes J., Lebret T., Compérat E.M., Cowan N.C., De Santis M., Bruins H.M. et al. Updated 2016 EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer. Eur. Urol. [Internet]. 2017; 71 (3): 462–75. DOI: 10.1016/ j.eururo.2016.06.020Alfred Witjes J., Lebret T., Compérat E.M., Cowan N.C., De Santis M., Bruins H.M. et al. Updated 2016 EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer. Eur. Urol. [Internet]. 2017; 71 (3): 462–75. DOI: 10.1016/ j.eururo.2016.06.020Bayoumi Y., Heikal T., Darweish H. Survival benefit of adjuvant radiotherapy in stage III and IV bladder cancer: results of 170 patients. Canc. Manag. Res.2014; 459. DOI: 10.2147/ cmar.s69055Bayoumi Y., Heikal T., Darweish H. Survival benefit of adjuvant radiotherapy in stage III and IV bladder cancer: results of 170 patients. Canc. Manag. Res.2014; 459. DOI: 10.2147/ cmar.s69055Tekes A., Kamel I., Imam K., Szarf G., Schoenberg M., Nasir K. et al. Dynamic MRI of bladder cancer: evaluation of staging accuracy. Am. J. Roentgenol. 2005; 184 (1): 121–7. DOI: 10.2214/ajr.184.1.01840121Tekes A., Kamel I., Imam K., Szarf G., Schoenberg M., Nasir K. et al. Dynamic MRI of bladder cancer: evaluation of staging accuracy. Am. J. Roentgenol. 2005; 184 (1): 121–7. DOI: 10.2214/ajr.184.1.01840121Yoshida S. Diffusion-weighted magnetic resonance imaging in management of bladder cancer, particularly with multimodal bladder-sparing strategy. World J. Radiol. 2014; 6 (6): 344. DOI: 10.4329/wjr.v6.i6.344Yoshida S. Diffusion-weighted magnetic resonance imaging in management of bladder cancer, particularly with multimodal bladder-sparing strategy. World J. Radiol. 2014; 6 (6): 344. DOI: 10.4329/wjr.v6.i6.344Григорьев Е.Г., Фролова И.Г., Усынин Е.А., Величко С.А., Окунев В.В., Гольдберг А.В. Рак мочевого пузыря: возможности высокопольной магнитно-резонансной томографии (Обзор литературы). Сибирский онкологический журнал. 2014; 3: 65–71.Grigor'ev E.G., Frolova I.G., Usynin E.A., Velichko S.A., Okunev V.V., Gol'dberg A.V. Role of high-field magnetic resonance imaging in diagnosis of bladder cancer (literature review). Siberian Journal of Oncology. 2014; 3: 65–71 (in Russ.).Takeuchi M., Sasaki S., Naiki T., Kawai N., Kohri K., Hara M. et al. MR imaging of urinary bladder cancer for T-staging: a review and a pictorial essay of diffusion-weighted imaging. J. Magn. Res. Imag. 2013; 38 (6): 1299–309. DOI: 10.1002/ jmri.24227Takeuchi M., Sasaki S., Naiki T., Kawai N., Kohri K., Hara M. et al. MR imaging of urinary bladder cancer for T-staging: a review and a pictorial essay of diffusion-weighted imaging. J. Magn. Res. Imag. 2013; 38 (6): 1299–309. DOI: 10.1002/ jmri.24227Takeuchi M., Sasaki S., Ito M., Okada S., Takahashi S., Kawai T. et al. Urinary bladder cancer: diffusion-weighted MR imaging – accuracy for diagnosing T stage and estimating histologic grade. Radiology. 2009; 251 (1): 112–21. DOI: 10.1148/radiol.2511080873Takeuchi M., Sasaki S., Ito M., Okada S., Takahashi S., Kawai T. et al. Urinary bladder cancer: diffusion-weighted MR imaging – accuracy for diagnosing T stage and estimating histologic grade. Radiology. 2009; 251 (1): 112–21. DOI: 10.1148/radiol.2511080873Watanabe H., Kanematsu M., Kondo H., Goshima S., Tsuge Y., Onozuka M. et al. Preoperative T staging of urinary bladder cancer: does diffusion-weighted MRI have supplementary value? Am. J. Roentgenol. 2009; 192 (5): 1361–6. DOI: 10.2214/ ajr.08.1430Watanabe H., Kanematsu M., Kondo H., Goshima S., Tsuge Y., Onozuka M. et al. Preoperative T staging of urinary bladder cancer: does diffusion-weighted MRI have supplementary value? Am. J. Roentgenol. 2009; 192 (5): 1361–6. DOI: 10.2214/ ajr.08.1430El-Assmy A., Abou-El-Ghar M.E., Mosbah A., El-Nahas A.R., Refaie H.F., Hekal I.A. et al. Bladder tumour staging: comparison of diffusion- and T2-weighted MR imaging. Eur. Radiol. 2009; 19 (7): 1575–81. DOI: 10.1007/s00330-0091340-7El-Assmy A., Abou-El-Ghar M.E., Mosbah A., El-Nahas A.R., Refaie H.F., Hekal I.A. et al. Bladder tumour staging: comparison of diffusion- and T2-weighted MR imaging. Eur. Radiol. 2009; 19 (7): 1575–81. DOI: 10.1007/s00330-0091340-7Hafeez S., Huddart R. Advances in bladder cancer imaging. BMC Medicine. 2013; 11 (1). DOI: 10.1186/1741-7015-11104Hafeez S., Huddart R. Advances in bladder cancer imaging. BMC Medicine. 2013; 11 (1). DOI: 10.1186/1741-7015-11104Wang H., Pui M.H., Guo Y., Yang D., Pan B., Zhou X. Diffusionweighted MRI in bladder carcinoma: the differentiation between tumor recurrence and benign changes after resection. Abdomin. Imag. 2013; 39 (1): 135–41. DOI: 10.1007/s00261-013-0038-0Wang H., Pui M.H., Guo Y., Yang D., Pan B., Zhou X. Diffusionweighted MRI in bladder carcinoma: the differentiation between tumor recurrence and benign changes after resection. Abdomin. Imag. 2013; 39 (1): 135–41. DOI: 10.1007/s00261-013-0038-0Nguyen H.T., Shah Z.K., Mortazavi A., Pohar K.S., Wei L., Jia G. et al. Non-invasive quantification of tumour heterogeneity in water diffusivity to differentiate malignant from benign tissues of urinary bladder: a phase I study. Eur. Radiol. 2016; 27 (5): 2146–52. DOI: 10.1007/s00330-0164549-2Nguyen H.T., Shah Z.K., Mortazavi A., Pohar K.S., Wei L., Jia G. et al. Non-invasive quantification of tumour heterogeneity in water diffusivity to differentiate malignant from benign tissues of urinary bladder: a phase I study. Eur. Radiol. 2016; 27 (5): 2146–52. DOI: 10.1007/s00330-0164549-2Narumi Y., Kadota T., Inoue E., Kuriyama K., Fujita M., Hosomi N. et al. Bladder tumors: staging with gadoliniumenhanced oblique MR imaging. Radiology. 1993; 187 (1): 145–50. DOI: 10.1148/radiology.187.1.8451401Narumi Y., Kadota T., Inoue E., Kuriyama K., Fujita M., Hosomi N. et al. Bladder tumors: staging with gadoliniumenhanced oblique MR imaging. Radiology. 1993; 187 (1): 145–50. DOI: 10.1148/radiology.187.1.8451401Wong-You–Cheong J.J., Woodward P.J., Manning M.A., Sesterhenn I.A. Neoplasms of the urinary bladder: radiologic-pathologic correlation. RadioGraphics. 2006; 26 (2): 553–80. DOI: 10.1148/rg.262055172Wong-You–Cheong J.J., Woodward P.J., Manning M.A., Sesterhenn I.A. Neoplasms of the urinary bladder: radiologic-pathologic correlation. RadioGraphics. 2006; 26 (2): 553–80. DOI: 10.1148/rg.262055172Matsuki M., Inada Y., Tatsugami F., Tanikake M., Narabayashi I., Katsuoka Y. Diffusion-weighted MR imaging for urinary bladder carcinoma: initial results. Eur. Radiol. 2006; 17 (1): 201–4. DOI: 10.1007/s00330-006-0281-7Matsuki M., Inada Y., Tatsugami F., Tanikake M., Narabayashi I., Katsuoka Y. Diffusion-weighted MR imaging for urinary bladder carcinoma: initial results. Eur. Radiol. 2006; 17 (1): 201–4. DOI: 10.1007/s00330-006-0281-7Kobayashi S., Koga F., Yoshida S., Masuda H., Ishii C., Tanaka H. et al. Diagnostic performance of diffusionweighted magnetic resonance imaging in bladder cancer: potential utility of apparent diffusion coefficient values as a biomarker to predict clinical aggressiveness. Eur. Radiol.2011; 21 (10): 2178–86. DOI: 10.1007/s00330-0112174-7Kobayashi S., Koga F., Yoshida S., Masuda H., Ishii C., Tanaka H. et al. Diagnostic performance of diffusionweighted magnetic resonance imaging in bladder cancer: potential utility of apparent diffusion coefficient values as a biomarker to predict clinical aggressiveness. Eur. Radiol.2011; 21 (10): 2178–86. DOI: 10.1007/s00330-0112174-7Abou-El-Ghar M.E., El-Assmy A., Refaie H.F., El-Diasty T. Bladder cancer: diagnosis with diffusion-weighted MR imaging in patients with gross hematuria. Radiology. 2009; 251 (2): 415–21. DOI: 10.1148/radiol.2503080723Abou-El-Ghar M.E., El-Assmy A., Refaie H.F., El-Diasty T. Bladder cancer: diagnosis with diffusion-weighted MR imaging in patients with gross hematuria. Radiology. 2009; 251 (2): 415–21. DOI: 10.1148/radiol.2503080723Ceylan K., Taken K., Gec ,it I., Pirinc ,c ,i N., Giines M., Karaman M. Comparison of cystoscopy with diffusion-weighted magnetic resonance images used in the diagnosis and follow-up of patients with bladder tumor. Eur. Urol. Suppl. 2010; 9 (6): 596–7. DOI: 10.1016/s1569-9056(10) 61441-8Ceylan K., Taken K., Gec ,it I., Pirinc ,c ,i N., Giines M., Karaman M. Comparison of cystoscopy with diffusion-weighted magnetic resonance images used in the diagnosis and follow-up of patients with bladder tumor. Eur. Urol. Suppl. 2010; 9 (6): 596–7. DOI: 10.1016/s1569-9056(10) 61441-8Afifi A.H., Abdel Maksoud T.A.S., EL-noueam K.I., Ataa M.A., Abdallah D.M. Multiparametric-MRI as a comprehensive study in evaluation, characterization & local staging of urinary bladder carcinomas. Egypt. J. Radiol. Nucl. Med. 2017; 48 (2): 493–507. DOI: 10.1016/j.ejrnm.2017.01.011Afifi A.H., Abdel Maksoud T.A.S., EL-noueam K.I., Ataa M.A., Abdallah D.M. Multiparametric-MRI as a comprehensive study in evaluation, characterization & local staging of urinary bladder carcinomas. Egypt. J. Radiol. Nucl. Med. 2017; 48 (2): 493–507. DOI: 10.1016/j.ejrnm.2017.01.011Wang H., Pui M.H., Guan J., Li S., Lin J., Pan B. et al. Comparison of early submucosal enhancement and tumor stalk in staging bladder urothelial carcinoma. Am. J. Roentgenol. 2016; 207 (4): 797–803. DOI: 10.2214/ajr.16.16283Wang H., Pui M.H., Guan J., Li S., Lin J., Pan B. et al. Comparison of early submucosal enhancement and tumor stalk in staging bladder urothelial carcinoma. Am. J. Roentgenol. 2016; 207 (4): 797–803. DOI: 10.2214/ajr.16.16283Alvarez Moreno E., Jimenez de la Pen ~a M., Cano Alonso R. Role of new functional MRI techniques in the diagnosis, staging, and followup of gynecological cancer: comparison with PET-CT. Radiol. Res. Pract.2012; 2012: 1–11. DOI: 10.1155/2012/219546Alvarez Moreno E., Jimenez de la Pen ~a M., Cano Alonso R. Role of new functional MRI techniques in the diagnosis, staging, and followup of gynecological cancer: comparison with PET-CT. Radiol. Res. Pract.2012; 2012: 1–11. DOI: 10.1155/2012/219546Down C.J., Nair R., Thurairaja R. Bladder cancer. Surgery (Oxford). 2016; 34 (10): 532–9. DOI: 10.1016/j.mpsur. 2016.08.001Down C.J., Nair R., Thurairaja R. Bladder cancer. Surgery (Oxford). 2016; 34 (10): 532–9. DOI: 10.1016/j.mpsur. 2016.08.001Kiss B., Thoeny H.C., Studer U.E. Current status of lymph node imaging in bladder and prostate cancer. Urology [Internet]. 2016; 96: 1–7. DOI: 10.1016/j.urology. 2016.02.014Kiss B., Thoeny H.C., Studer U.E. Current status of lymph node imaging in bladder and prostate cancer. Urology [Internet]. 2016; 96: 1–7. DOI: 10.1016/j.urology. 2016.02.014Rechichi G., Galimberti S., Oriani M., Perego P., Valsecchi M.G., Sironi S. ADC maps in the prediction of pelvic lymph nodal metastatic regions in endometrial cancer. Eur. Radiol. 2012; 23 (1): 65–74. DOI: 10.1007/s00330-0122575-2Rechichi G., Galimberti S., Oriani M., Perego P., Valsecchi M.G., Sironi S. ADC maps in the prediction of pelvic lymph nodal metastatic regions in endometrial cancer. Eur. Radiol. 2012; 23 (1): 65–74. DOI: 10.1007/s00330-0122575-2Beer A.J., Eiber M., Souvatzoglou M., Holzapfel K., Ganter C., Weirich G. et al. Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in 11C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer. Mol. Imag. Biol.2010; 13 (2): 352–61. DOI: 10.1007/s11307-010-0337-6Beer A.J., Eiber M., Souvatzoglou M., Holzapfel K., Ganter C., Weirich G. et al. Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in 11C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer. Mol. Imag. Biol.2010; 13 (2): 352–61. DOI: 10.1007/s11307-010-0337-6Papalia R., Simone G., Grasso R., Augelli R., Faiella E., Guaglianone S. et al. Diffusion-weighted magnetic resonance imaging in patients selected for radical cystectomy: detection rate of pelvic lymph node metastases. BJU Intern. 2011; 109 (7): 1031–6. DOI: 10.1111/j.1464-410x.2011. 10446.xPapalia R., Simone G., Grasso R., Augelli R., Faiella E., Guaglianone S. et al. Diffusion-weighted magnetic resonance imaging in patients selected for radical cystectomy: detection rate of pelvic lymph node metastases. BJU Intern. 2011; 109 (7): 1031–6. DOI: 10.1111/j.1464-410x.2011. 10446.xMir N., Sohaib S., Collins D., Koh D. Fusion of high b-value diffusion-weighted and T2-weighted MR images improves identification of lymph nodes in the pelvis. J. Med. Imag. Radiat. Oncol. 2010; 54 (4): 358–64. DOI: 10.1111/j.17549485.2010.02182.xMir N., Sohaib S., Collins D., Koh D. Fusion of high b-value diffusion-weighted and T2-weighted MR images improves identification of lymph nodes in the pelvis. J. Med. Imag. Radiat. Oncol. 2010; 54 (4): 358–64. DOI: 10.1111/j.17549485.2010.02182.xThoeny H.C., Triantafyllou M., Birkhaeuser F.D., Froehlich J.M., Tshering D.W., Binser T. et al. Combined ultrasmall superparamagnetic particles of iron oxide – enhanced and diffusion-weighted magnetic resonance imaging reliably detect pelvic lymph node metastases in normal-sized nodes of bladder and prostate cancer patients. Eur. Urol. 2009; 55 (4): 761–9. DOI: 10.1016/j.eururo.2008.12.034Thoeny H.C., Triantafyllou M., Birkhaeuser F.D., Froehlich J.M., Tshering D.W., Binser T. et al. Combined ultrasmall superparamagnetic particles of iron oxide – enhanced and diffusion-weighted magnetic resonance imaging reliably detect pelvic lymph node metastases in normal-sized nodes of bladder and prostate cancer patients. Eur. Urol. 2009; 55 (4): 761–9. DOI: 10.1016/j.eururo.2008.12.034Birkhäuser F.D., Studer U.E., Froehlich J.M., Triantafyllou M., Bains L.J., Petralia G. et al. Combined ultrasmall superparamagnetic particles of iron oxide – enhanced and diffusionweighted magnetic resonance imaging facilitates detection of metastases in normal-sized pelvic lymph nodes of patients with bladder and prostate cancer. Eur. Urol. 2013; 64 (6): 953–60. DOI: 10.1016/j.eururo.2013.07.03Birkhäuser F.D., Studer U.E., Froehlich J.M., Triantafyllou M., Bains L.J., Petralia G. et al. Combined ultrasmall superparamagnetic particles of iron oxide – enhanced and diffusionweighted magnetic resonance imaging facilitates detection of metastases in normal-sized pelvic lymph nodes of patients with bladder and prostate cancer. Eur. Urol. 2013; 64 (6): 953–60. DOI: 10.1016/j.eururo.2013.07.03Rosenkrantz A.B., Mussi T.C., Spieler B., Melamed J., Taneja S.S., Huang W.C. High-grade bladder cancer: association of the apparent diffusion coefficient with metastatic disease: preliminary results. J. Magn. Res. Imag.2012; 35 (6): 1478–83. DOI: 10.1002/jmri.23590Rosenkrantz A.B., Mussi T.C., Spieler B., Melamed J., Taneja S.S., Huang W.C. High-grade bladder cancer: association of the apparent diffusion coefficient with metastatic disease: preliminary results. J. Magn. Res. Imag.2012; 35 (6): 1478–83. DOI: 10.1002/jmri.23590Kobayashi S., Koga F., Kajino K., Yoshita S., Ishii C., Tanaka H. et al. Apparent diffusion coefficient value reflects invasive and proliferative potential of bladder cancer. J. Magn. Res. Imag. 2013; 39 (1): 172–8. DOI: 10.1002/jmri.24148Kobayashi S., Koga F., Kajino K., Yoshita S., Ishii C., Tanaka H. et al. Apparent diffusion coefficient value reflects invasive and proliferative potential of bladder cancer. J. Magn. Res. Imag. 2013; 39 (1): 172–8. DOI: 10.1002/jmri.24148Ohgiya Y., Suyama J., Sai S., Kawahara M., Takeyama N., Ohike N. et al. Preoperative T staging of urinary bladder cancer: efficacy of stalk detection and diagnostic performance of diffusion-weighted imaging at 3T. Magn. Res. Med. Sc. 2014; 13 (3): 175–81. DOI: 10.2463/mrms.2013-0104Ohgiya Y., Suyama J., Sai S., Kawahara M., Takeyama N., Ohike N. et al. Preoperative T staging of urinary bladder cancer: efficacy of stalk detection and diagnostic performance of diffusion-weighted imaging at 3T. Magn. Res. Med. Sc. 2014; 13 (3): 175–81. DOI: 10.2463/mrms.2013-0104Huddart R.A., Jones R., Choudhury A. A new dawn for bladder cancer? Recommendations from the National Institute for Health and Care Excellence (NICE) on Managing Bladder Cancer. Clin. Oncol. 2015; 27 (7): 380–1. DOI: 10.1016/ j.clon.2015.03.008Huddart R.A., Jones R., Choudhury A. A new dawn for bladder cancer? Recommendations from the National Institute for Health and Care Excellence (NICE) on Managing Bladder Cancer. Clin. Oncol. 2015; 27 (7): 380–1. DOI: 10.1016/ j.clon.2015.03.008Долгушин Б.И., Тюрин И.Е., Лукьянченко А.Б., Медведева Б.М., Дронова Е.Л., Шима Вольфган, Рингл Вельмут. Стандарты проведения КТ-и МРТ-исследований в онкологии сиспользованием внутривенного контрастного усиления. Медицинский алфавит. 2013; 3-4 (23): 29–37.Dolgushin B.I., Tyurin I.E., Luk’yanchenko A.B., Medvedeva B.M., Dronova E.L., Shima Volfgan, Ringl Velmut. Standards for CT and MRI studies in oncology using intravenous contrast enhancement. Medical Alphabet. 2013; 3-4 (23): 29–37 (in Russ.).

The authors declare that there are no conflicts of interest present.