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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rentrad</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник рентгенологии и радиологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of radiology and nuclear medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0042-4676</issn><issn pub-type="epub">2619-0478</issn><publisher><publisher-name>Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20862/0042-4676-2019-100-6-335-338</article-id><article-id custom-type="elpub" pub-id-type="custom">rentrad-514</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Возможность определения концентрации йода в фантоме с известными титрами йодсодержащего контрастного препарата при помощи двухэнергетической компьютерной томографии</article-title><trans-title-group xml:lang="en"><trans-title>The Possibility for Iodine Concentration Determination in a Phantom with Known Titers of an Iodine-Containing Contrast Agent, by Using Dual-Energy Computed Tomography</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5661-0620</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чабан</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Chaban</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чабан Артем Сергеевич, врач-рентгенолог</p><p> </p></bio><bio xml:lang="en"><p>Artem S. Chaban, Radiologist</p><p>ul. Nizhegorodskaya, 83, stroenie 1, Moscow, 109052</p></bio><email xlink:type="simple">chabanartem91@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5649-2193</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синицын</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Sinitsyn</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Синицын Валентин Евгеньевич, д. м. н., профессор, заведующий кафедрой лучевой диагностики и лучевой терапии</p><p>Ломоносовский пр-т, 27, корп. 1, Москва, 119991</p></bio><bio xml:lang="en"><p>Valentin E. Sinitsyn, Dr. Med. Sc., Professor, Chief of Radiology and Radiotherapy Chair</p><p>Lomonosovskiy prospekt, 27, korpus 1, Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ООО «Медскан»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medscan</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Lomonosov Moscow State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>25</day><month>01</month><year>2020</year></pub-date><volume>100</volume><issue>6</issue><fpage>335</fpage><lpage>338</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чабан А.С., Синицын В.Е., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Чабан А.С., Синицын В.Е.</copyright-holder><copyright-holder xml:lang="en">Chaban A.S., Sinitsyn V.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.russianradiology.ru/jour/article/view/514">https://www.russianradiology.ru/jour/article/view/514</self-uri><abstract><p>Цель исследования – изучение возможностей двухэнергетической компьютерной томографии (ДЭКТ) с одним источником излучения в количественной оценке концентрации йода в растворах.</p><sec><title>Материал иметоды</title><p> Материал иметоды.Проведена компьютерная томография содним источником излучения вдвухэнергетическом режиме на фантоме, представлявшем собой набор из 5 пробирок с разным титром йодсодержащего контрастного препарата Йопамидола. На основе полученных изображений были построены йодные карты, и в пределах объема титрованного контрастного препарата измерена концентрация йода.</p></sec><sec><title>Результаты</title><p>Результаты. Несмотря на высокую степень корреляции измеренной концентрации йода в растворе с истинной концентрацией (коэффициент корреляции Пирсона r=0,98; p&lt;0,01), имеется погрешность в измерении, которая варьировала от 4,8 до 23% при разных разведениях.</p></sec><sec><title>Заключение</title><p> Заключение. ДЭКТ с одним источником излучения с быстрым переключением напряжения не позволяет с высокой точностью измерить истинную концентрацию йода в растворе. Для устранения погрешности измерений в дальнейших исследованиях с использованием ДЭКТ с одним источником излучения in vivo, возможно, следует обратить внимание на измерение нормализованной концентрации йода. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to study the capabilities of single-source dual-energy computed tomography (DECT) in quantifying the concentration of iodine in solutions.</p></sec><sec><title>Material and methods</title><p>Material and methods. Single-source DECT was performed using a phantom containing a set of 5 tubes with a different titer of the iodine-containing contrast agent Iopamidol. Further, the obtained images were used to construct iodine maps; and the concentration of iodine was measured within the volume of the titrated contrast agent.</p></sec><sec><title>Results</title><p>Results. Despite a high correlation between the measured iodine concentration in solution with the true concentration (Pearson's correlation coefficient r = 0.98; p &lt; 0.01), there is a measurement error that was 4.8 to 23% at different dilutions.</p></sec><sec><title>Conclusion</title><p>Conclusion. Signal-source rapid voltage switching DECT does not allow precise measurements of the true concentration of iodine in solution. To eliminate measurement errors in further in vivo studies using singlesource DECT, it may be that attention must be paid to the measurement of normalized iodine concentration. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>двухэнергетическая компьютерная томография</kwd><kwd>фантом</kwd><kwd>концентрация йода</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dual-energy computed tomography</kwd><kwd>phantom</kwd><kwd>iodine concentration</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Euler A., Solomon J., Mazurowski M.A., Samei E., Nelson R.C. How accurate and precise are CT based measurements of iodine concentration? A comparison of the minimum detectable concentration difference among single source and dual source dual energy CT in a phantom study. Eur. Radiol. 2019; 29 (4): 2069–78. DOI: 10.1007/s00330-018-5736-0</mixed-citation><mixed-citation xml:lang="en">Euler A., Solomon J., Mazurowski M.A., Samei E., Nelson R.C. How accurate and precise are CT based measurements of iodine concentration? A comparison of the minimum detectable concentration difference among single source and dual source dual energy CT in a phantom study. Eur. Radiol. 2019; 29 (4): 2069–78. DOI: 10.1007/s00330-018-5736-0</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Coursey C.A., Nelson R.C., Boll D.T., Paulson E.K., Ho L.M., Neville A.M. et al. Dual-energy multidetector CT: how does it work, what can it tell us, and when can we use it in abdominopelvic imaging? Radiographics. 2010; 30: 1037–55. DOI: 10.1148/rg.304095175</mixed-citation><mixed-citation xml:lang="en">Coursey C.A., Nelson R.C., Boll D.T., Paulson E.K., Ho L.M., Neville A.M. et al. Dual-energy multidetector CT: how does it work, what can it tell us, and when can we use it in abdominopelvic imaging? Radiographics. 2010; 30: 1037–55. DOI: 10.1148/rg.304095175</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hartman R., Kawashima A., Takahashi N., Silva A., Vrtiska T., Leng S. et al. Applications of dual-energy CT in urologic imaging: an update. Radiol. Clin. North Am. 2012; 50: 191–205. DOI: 10.1016/j.rcl.2012.02.007</mixed-citation><mixed-citation xml:lang="en">Hartman R., Kawashima A., Takahashi N., Silva A., Vrtiska T., Leng S. et al. Applications of dual-energy CT in urologic imaging: an update. Radiol. Clin. North Am. 2012; 50: 191–205. DOI: 10.1016/j.rcl.2012.02.007</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kaza R.K., Platt J.F., Cohan R.H., Caoili E.M., Al-Hawary M.M., Wasnik A. Dual-energy CT with single- and dual-source scanners: current applications in evaluating the genitourinary tract. RadioGraphics. 2012; 32: 353–69. DOI: 10.1148/ rg.322115065</mixed-citation><mixed-citation xml:lang="en">Kaza R.K., Platt J.F., Cohan R.H., Caoili E.M., Al-Hawary M.M., Wasnik A. Dual-energy CT with single- and dual-source scanners: current applications in evaluating the genitourinary tract. RadioGraphics. 2012; 32: 353–69. DOI: 10.1148/ rg.322115065</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Fornaro J., Leschka S., Hibbeln D., Butler A., Anderson N., Pache G. et al. Dual- and multi-energy CT: approach to functional imaging. Insights Imaging. 2011; 2: 149–59. DOI: 10.1007/s13244-010-0057-0</mixed-citation><mixed-citation xml:lang="en">Fornaro J., Leschka S., Hibbeln D., Butler A., Anderson N., Pache G. et al. Dual- and multi-energy CT: approach to functional imaging. Insights Imaging. 2011; 2: 149–59. DOI: 10.1007/s13244-010-0057-0</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Graser A., Johnson T.R.C., Chandarana H., Macari M. Dual energy CT: Preliminary observations and potential clinical applications in the abdomen. Eur. Radiol. 2009; 19: 13–23. DOI: 10.1007/s00330-008-1122-7</mixed-citation><mixed-citation xml:lang="en">Graser A., Johnson T.R.C., Chandarana H., Macari M. Dual energy CT: Preliminary observations and potential clinical applications in the abdomen. Eur. Radiol. 2009; 19: 13–23. DOI: 10.1007/s00330-008-1122-7</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Silva A.C., Morse B.G., Hara A.K., Paden R.G., Hongo N., Pavlicek W. Dual-energy (spectral) CT: applications in abdominal imaging. RadioGraphics. 2011; 31: 1031–46. DOI: 10.1148/ rg.314105159</mixed-citation><mixed-citation xml:lang="en">Silva A.C., Morse B.G., Hara A.K., Paden R.G., Hongo N., Pavlicek W. Dual-energy (spectral) CT: applications in abdominal imaging. RadioGraphics. 2011; 31: 1031–46. DOI: 10.1148/ rg.314105159</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson T.R.C., Trc J. Dual-energy CT: general principles. Am. J. Roentgenol.2012; 199: 3–8. DOI: 10.2214/AJR.12.9116</mixed-citation><mixed-citation xml:lang="en">Johnson T.R.C., Trc J. Dual-energy CT: general principles. Am. J. Roentgenol.2012; 199: 3–8. DOI: 10.2214/AJR.12.9116</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Pourmorteza A., Symons R., Sandfort V., Mallek M., Fuld M.K., Henderson G. et al. Abdominal imaging with contrastenhanced photon-counting CT: first human experience. Radiology. 2016; 279 (1): 1–7. DOI: 10.1148/radiol. 2016152601</mixed-citation><mixed-citation xml:lang="en">Pourmorteza A., Symons R., Sandfort V., Mallek M., Fuld M.K., Henderson G. et al. Abdominal imaging with contrastenhanced photon-counting CT: first human experience. Radiology. 2016; 279 (1): 1–7. DOI: 10.1148/radiol. 2016152601</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Wang X., Meier D., Taguchi K., Wagenaar D.J., Patt B.E., Frey E.C. et al. Material separation in X-ray CT with energy resolved photon-counting detectors. Med. Phys. 2011; 38: 1534–46. DOI: 10.1118/1.3553401</mixed-citation><mixed-citation xml:lang="en">Wang X., Meier D., Taguchi K., Wagenaar D.J., Patt B.E., Frey E.C. et al. Material separation in X-ray CT with energy resolved photon-counting detectors. Med. Phys. 2011; 38: 1534–46. DOI: 10.1118/1.3553401</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Pelgrim G.J., van Hamersvelt R.W., Willemink M.J., Schmidt B.T., Flohr T., Schilham A. et al. Accuracy of iodine quantification using dual energy CT in latest generation dual source and dual layer CT. Eur. Radiol. 2017; 27 (9): 3904–12. DOI: 10.1007/s00330-017-4752-9</mixed-citation><mixed-citation xml:lang="en">Pelgrim G.J., van Hamersvelt R.W., Willemink M.J., Schmidt B.T., Flohr T., Schilham A. et al. Accuracy of iodine quantification using dual energy CT in latest generation dual source and dual layer CT. Eur. Radiol. 2017; 27 (9): 3904–12. DOI: 10.1007/s00330-017-4752-9</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lv P., Lin X.Z., Li J., Li W., Chen K. Differentiation of small hepatic hemangioma from small hepatocellular carcinoma: recently introduced spectral CT method. Radiology. 2011; 259: 720–9. DOI: 10.1148/radiol.11101425</mixed-citation><mixed-citation xml:lang="en">Lv P., Lin X.Z., Li J., Li W., Chen K. Differentiation of small hepatic hemangioma from small hepatocellular carcinoma: recently introduced spectral CT method. Radiology. 2011; 259: 720–9. DOI: 10.1148/radiol.11101425</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
