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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rentrad</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник рентгенологии и радиологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of radiology and nuclear medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0042-4676</issn><issn pub-type="epub">2619-0478</issn><publisher><publisher-name>Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20862/0042-4676-2014-0-5-26-33</article-id><article-id custom-type="elpub" pub-id-type="custom">rentrad-46</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>ЭФФЕКТИВНОСТЬ УЛЬТРАЗВУКОВОГО ИССЛЕДОВАНИЯ В ДИАГНОСТИКЕ ХОЛАНГИОЦЕЛЛЮЛЯРНОГО РАКА</article-title><trans-title-group xml:lang="en"><trans-title>EFFICIENCY OF ULTRASOUND STUDY IN THE DIAGNOSIS OF CHOLANGIOCELLULAR CARCINOMA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данзанова</surname><given-names>Т. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Danzanova</surname><given-names>T. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., ст. науч. сотр. отделения ультразвуковой диагностики отдела лучевой диагностики и интервенционной радиологии</p><p>Каширское шоссе, 23, Москва, 115478</p></bio><bio xml:lang="en"><p>MD, PhD, Senior Researcher of Department of Ultrasound Diagnostics in Department of Radiology and Interventional Radiology</p><p>Kashirskoye shosse, 23, Moscow, 115478</p></bio><email xlink:type="simple">danzanova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синюкова</surname><given-names>Г. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Sinyukova</surname><given-names>G. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор, заведующая отделением ультразвуковой диагностики отдела лучевой диагностики и интервенционной радиологии</p><p>Каширское шоссе, 23, Москва, 115478</p></bio><bio xml:lang="en"><p>MD, PhD, DSc, Professor, Head of Department of Ultrasound Diagnostics in Department of Radiology and Interventional Radiology</p><p>Kashirskoye shosse, 23, Moscow, 115478</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лепэдату</surname><given-names>П. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Lepedatu</surname><given-names>P. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., ст. науч. сотр. отделения ультразвуковой диагностики отдела лучевой диагностики и интервенционной радиологии</p><p>Каширское шоссе, 23, Москва, 115478</p></bio><bio xml:lang="en"><p>MD, PhD, Senior Researcher of Department of Ultrasound Diagnostics in Department of Radiology and Interventional Radiology</p><p>Kashirskoye shosse, 23, Moscow, 115478</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудашкин</surname><given-names>Н. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudashkin</surname><given-names>N. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., науч. сотр. отделения опухолей печени и поджелудочной железы </p><p>Каширское шоссе, 23, Москва, 115478</p></bio><bio xml:lang="en"><p>MD, PhD, Researcher of Department of Tumors of the Liver and Pancreas </p><p>Kashirskoye shosse, 23, Moscow, 115478</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.N. Blokhin Russian Oncological Research Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2016</year></pub-date><volume>0</volume><issue>5</issue><fpage>26</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Данзанова Т.Ю., Синюкова Г.Т., Лепэдату П.И., Кудашкин Н.Е., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Данзанова Т.Ю., Синюкова Г.Т., Лепэдату П.И., Кудашкин Н.Е.</copyright-holder><copyright-holder xml:lang="en">Danzanova T.Y., Sinyukova G.T., Lepedatu P.I., Kudashkin N.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.russianradiology.ru/jour/article/view/46">https://www.russianradiology.ru/jour/article/view/46</self-uri><abstract><p>Цель исследования – оценить эффективность ультразвуковой диагностики в выявлении и стадировании холангиоцел- люлярного рака.</p><sec><title>Материал и методы</title><p>Материал и методы. Проведено ультразвуковое исследо- вание (УЗИ) 120 больных холангиоцеллюлярным раком в воз- расте от 19 до 84 лет. Больные были разделены на три группы по локализации опухолевого процесса: внутрипеченочная – 47 (39,2%), воротная, или опухоль Клатскина, – 49 (40,8%), дистальная – 24 (20%). Были прооперированы 90 (75%) боль- ных, остальным проведены малоинвазивные рентгенохирурги- ческие вмешательства в виде чрескожных чреспеченочных хо- лангиостомий. Данные ультразвуковой диагностики сопостав- лялись с результатами других методов обследования, хирургической оценкой во время операции и морфологичес- ким исследованием удаленного макропрепарата.</p></sec><sec><title>Результаты</title><p>Результаты. Опухоль определялась методом УЗИ только у 90 (75%) пациентов, чувствительность составила: при внутрипеченочном типе холангиоцеллюлярного рака – 100%, воротном типе – 69,4%, дистальном типе – 37,5%. Сложнее всего диагностировать новообразования дистальных отделов общего желчного протока. При УЗИ не обнаружено семиотических признаков внутрипеченочного холангиоцеллюлярного рака, которые позволили бы отличить его от других злокачественных новообразований печени. Выявлена особенность инфильтративного роста опухоли желчных протоков – гиперэхогенная структура инфильтрации вдоль наружного контура протоков или гипоэхогенная структура инфильтрации при утолщении стенок протоков. Чувствительность интраоперационного УЗИ в определении внутрипеченочной и воротной холангиокарциномы составила 100%. Чувствительность УЗИ в обнаружении метастатических лимфоузлов составила 61%, авторами разработана семиотика измененных метастатических лимфатических узлов.</p></sec><sec><title>Заключение</title><p>Заключение. Результаты исследования показали высокую информативность ультразвуковой диагностики в определении расширения желчных протоков, распространения опухоли на печень и лимфатические узлы. Рекомендовано расширить показания к интраоперационному УЗИ при внепеченочном холангиоцеллюлярном раке для определения границ опухолевого поражения протоков.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to evaluate the efficiency of ultrasound diagnosis in detecting and staging cholangiocellular carcinoma.</p></sec><sec><title>Material and methods</title><p>Material and methods. An ultrasound study (USS) was conducted in 120 patients aged 19 to 84 years with cholangiocellular carcinoma. The patients were divided into 3 groups by the location of a tumor process: 1) 47 (39.2%) patients with intrahepatic tumor; 2) 49 (40.8%) with portal duct or Klatskin’s tumor; 3) 24 (20%) with distal one. Ninety (75%) patients were operated on; the others underwent minimally invasive X-ray surgical interventions as percutaneous transhepatic cholangiostomies. The data of ultrasound diagnosis were compared with the results of other studies, intraoperative assessment and morphological examination of a removed gross specimen.</p></sec><sec><title>Results</title><p>Results. A tumor was detectable by USS only in 90 (75%) patients; its sensitivity was 100% for intrahepatic cholangiocellular carcinoma; 69.4 and 37.5% for portal duct and distal ones, respectively. It is most difficult to diagnose distal carcinomas of the common bile duct. USS reveals no semiotic signs of intrahepatic cholangiocellular carcinoma, which could distinguish the latter from other liver cancers. The specific features of the infiltrative growth of a bile duct tumor, such as hyperechoic infiltration along the external outlines of the ducts or hypoechoic infiltration during thickening of the duct walls, were ascertained. The sensitivity of intraoperative USS in identifying intrahepatic and portal duct cholangiocarcinoma was 100%. That of USS in detecting lymph node metastases was 61%; we developed the semiotics of altered metastatic lymph nodes.</p></sec><sec><title>Conclusion</title><p>Conclusion. The findings have indicated the high informative value of ultrasound diagnosis in determining the dilatation of the bile ducts and the spread of a tumor to the liver and lymph nodes. It is recommended that the indications for intraoperative USS should be expanded in intrahepatic cholangiocellular carcinoma to define the extent of duct carcinoma.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>холангиоцеллюлярный рак</kwd><kwd>ультразвук</kwd><kwd>диагностика</kwd><kwd>желчные протоки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cholangiocellular carcinoma</kwd><kwd>ultrasound</kwd><kwd>diagnosis</kwd><kwd>bile ducts</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Blechacz B.R., Gores G.J. 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