rentradВестник рентгенологии и радиологииJournal of radiology and nuclear medicine0042-46762619-0478Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists10.20862/0042-4676-2019-100-2-102-110rentrad-449Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL RESEARCHЗначение диффузионно-взвешенной магнитно-резонансной томографии в предоперационной оценке степени злокачественности глиом головного мозгаThe Value of Diffusion-weighted Magnetic Resonance Imaging in the Preoperative Evaluation of the Grade of Brain Gliomashttps://orcid.org/0000-0003-4349-7101БывальцевВ. А.ByvaltsevV. A.

Бывальцев Вадим Анатольевич, доктор медицинских наук, заведующий кафедрой нейрохирургии и инновационной медицины, ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России; главный нейрохирург, ОАО «РЖД»; руководитель Центра нейрохирургии, НУЗ «Дорожная клиническая больница на станции Иркутск-Пассажирский ОАО “РЖД”»; заведующий научно-клиническим отделом нейрохирургии, ФГБНУ «Иркутский научный центр хирургии и травматологии»; профессор кафедры травматологии, ортопедии и нейрохирургии, Иркутская государственная медицинская академия последипломного образования – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

ул. Красного Восстания, 1, Иркутск, 664003, 

ул. Боткина, 10, Иркутск, 664005, 

ул. Борцов Революции, 1, Иркутск, 664003, 

мкр-н Юбилейный, 100, Иркутск, 664049

Vadim A. Byvaltsev, Dr. Med. Sc., Chief of Chair of Neurosurgery and Innovative Medicine, Irkutsk State Medical University, Ministry of Health of the Russian Federation; Chief Neurosurgeon of Russian Railways; Head of Neurosurgery Center, Road Clinical Hospital at the station of Irkutsk-Passenger, Russian Railways Ltd.; Head of Scientific and Clinical Department of Neurosurgery, Irkutsk Scientific Center of Surgery and Traumatology; Professor of Chair of Traumatology, Orthopedics and Neurosurgery, Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russian Federation

ul. Krasnogo Vosstaniya, 1, Irkutsk, 664003, 

ul. Botkina, 10, Irkutsk, 664005, 

ul. Bortsov Revolyutsii, 1, Irkutsk, 664003, 

 mikrorayon Yubileynyy, 100, Irkutsk, 664049

 

byval75vadim@yandex.ruhttps://orcid.org/0000-0001-9039-9147СтепановИ. А.StepanovI. A.

Степанов Иван Андреевич, аспирант

ул. Красного Восстания, 1, Иркутск, 664003

Ivan A. Stepanov, Postgraduate

ul. Krasnogo Vosstaniya, 1, Irkutsk, 664003

 

https://orcid.org/0000-0001-8763-2905КичигинА. И.KichiginA. I.

Кичигин Александр Иванович, аспирант

ул. Красного Восстания, 1, Иркутск, 664003

Aleksandr I. Kichigin, Postgraduate

ul. Krasnogo Vosstaniya, 1, Irkutsk, 664003

 

ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России; НУЗ «Дорожная клиническая больница на станции Иркутск-Пассажирский ОАО “РЖД”»; ФГБНУ «Иркутский научный центр хирургии и травматологии»; Иркутская государственная медицинская академия последипломного образования – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияIrkutsk State Medical University, Ministry of Health of the Russian Federation; Road Clinical Hospital at the station of Irkutsk-Passenger, Russian Railways Ltd.; Irkutsk Scientific Center of Surgery and Traumatology; Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russian FederationRussian FederationФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава РоссииРоссияIrkutsk State Medical University, Ministry of Health of the Russian FederationRussian Federation2019210520191002102110Copyright © Бывальцев В.А., Степанов И.А., Кичигин А.И., 20192019Бывальцев В.А., Степанов И.А., Кичигин А.И.Byvaltsev V.A., Stepanov I.A., Kichigin A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.russianradiology.ru/jour/article/view/449

Цель исследования – сопоставление полученных значений измеряемого коэффициента диффузии (ИКД) глиом головного мозга с клеточной плотностью и индексом пролиферативной активности Ki-67, а также изучение возможности применения диффузионно-взвешенной МРТ (ДВ МРТ) в предоперационной оценке степени злокачественности глиальных опухолей.

Материал и методы

Материал и методы. Исследованы диффузионно-взвешенные изображения 39 пациентов с глиомами головного мозга. Для каждой опухоли рассчитаны ИКД, клеточная плотность и индекс пролиферативной активности Ki-67, выполнен корреляционный анализ между ними.

Результаты

Результаты. При сравнении средних значений ИКД получено достоверное различие между опухолями G=I–II и G=III–IV. Сравнение средних значений индекса Ki-67 между глиомами различной степени злокачественности показало наличие статистически значимых различий. При оценке корреляции между ИКД и значениями индекса пролиферативной активности Ki-67 отмечена умеренная и выраженная обратная корреляционная зависимость соответственно для глиальных опухолей низкой и высокой степени злокачественности.

Заключение

Заключение. Методика ДВ МРТ с подсчетом ИКД может быть использована в качестве дополнительного неинвазивного метода предоперационной оценки степени злокачественности и пролиферативного потенциала глиом головного мозга.

Objective

Objective. To compare the values obtained for the measured diffusion coefficient (MDC) of brain gliomas with cell density and Ki-67 proliferative activity index and to study whether diffusion-weighted MRI (DWMRI) can be used in the preoperative evaluation of the grade of glial tumors.

Material and methods

Material and methods. Diffusion-weighted images of 39 patients with brain gliomas were studied. MDC, cell density, and Ki-67 proliferative activity index were calculated for each tumor. The correlation between MDC values, cell density, and Ki-67 proliferative activity index was analyzed.

Results

Results. Comparison of the mean values for MDC revealed a significant difference between grades I–II and III–IV tumors. There were statistically significant differences in the mean Ki-67 index between different grades of gliomas. Evaluation of the correlation between MCD and Ki-67 proliferative activity index demonstrated moderate and strong inverse correlations for low- and high-grade tumors, respectively.

Conclusion

Conclusion. The procedure using DW-MRI along with MDC calculation can be used as an additional noninvasive method for the preoperative estimation of the grade and proliferative potential of brain gliomas.

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The authors declare that there are no conflicts of interest present.