rentradВестник рентгенологии и радиологииJournal of radiology and nuclear medicine0042-46762619-0478Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists10.20862/0042-4676-2018-99-6-305-309rentrad-397Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL RESEARCHПрименение метода маркирования артериальных спинов (ASL-перфузия) для оценки резидуальной ткани глиобластомыUsing the arterial spins labeling method (ASL-perfusion) for evaluation of glioblastoma residual tissuehttps://orcid.org/0000-0001-6436-0249БунакМ. С.BunakM. S.

Бунак Марк Сергеевич - младший научный сотрудник.

Ул. Щепкина, 61/2, корп. 1, Москва, 129110

Mark S. Bunak - Junior Researcher.

Ul. Shchepkina, 61/2, korpus 1, Moscow, 129110

mark-bunak@mail.ruhttps://orcid.org/0000-0003-3838-636XВишняковаМ. В.VishnyakovaM. V.

Доктор медицинских наук, профессор кафедры лучевой диагностики, руководитель рентгенологического отдела.

Ул. Щепкина, 61/2, корп. 1, Москва, 129110

Dr. Med. Sc., Professor of the Chair of Radiology, Head of Radiology Department.

Ul. Shchepkina, 61/2, korpus 1, Moscow, 129110

https://orcid.org/0000-0003-1058-0611СташукГ. А.StashukG. A.

Доктор медицинских наук, профессор кафедры лучевой диагностики, главный научный сотрудник.

Ул. Щепкина, 61/2, корп. 1, Москва, 129110

Dr. Med. Sc., Professor of the Chair of Radiology, Chief Researcher.

https://orcid.org/0000-0003-4020-158XБиктимировР. Г.BiktimirovR. G.

Кандидат медицинских наук, старший научный сотрудник.

Ул. Щепкина, 61/2, корп. 1, Москва, 129110

Cand. Med. Sc., Senior Researcher.

Ul. Shchepkina, 61/2, korpus 1, Moscow, 129110

ГБУЗ МО Московский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоРоссияMoscow Regional Research and Clinical InstituteRussian Federation201802012019996305309Copyright © Бунак М.С., Вишнякова М.В., Сташук Г.А., Биктимиров Р.Г., 20192019Бунак М.С., Вишнякова М.В., Сташук Г.А., Биктимиров Р.Г.Bunak M.S., Vishnyakova M.V., Stashuk G.A., Biktimirov R.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.russianradiology.ru/jour/article/view/397

Цель исследования - изучить эффективность применения ASL-перфузии в качестве метода оценки гемодинамики и выявления остаточной ткани опухоли после оперативного лечения.

Материал и методы

Материал и методы. Обследованы 56 пациентов после хирургического удаления глиобластомы (GRADE IV). Определялись средние показатели CBF в трех разных участках -в предположительной ткани опухоли (ПТО) с максимальной перфузией, в послеоперационной рубцовой ткани (ПРТ) и в белом веществе (БВ) на уровне семиовальных центров противоположного полушария. В зависимости от показателей CBF пациенты были разделены на две группы.

Результаты

Результаты. В 1-ю группу включены 38 (67,9%) пациентов со средним показателем CBF в ПТО 137,6±35,2 (79,6-227,б) мл/100 г/мин. В данном участке CBF был в 6-8 раз выше, чем в БВ, и в 5-6 раз выше показателей кровотока в ПРТ.

Группа 2 состояла из 18 (32,1%) пациентов без патологического повышения CBF на фоне ПРТ: 22,3±5,9 (13,9-37,1) мл/100 г/мин.

Уровень CBF в ПРТ у пациентов 1-й и 2-й групп достоверно не различался (р = 0,52). Также не выявлено статистически значимых различий между группами по уровню CBF в БВ (р = 0,96).

Заключение

Заключение. Возможностей ASL-перфузии достаточно для выявления остаточной ткани опухоли после хирургического лечения глиом высокой степени злокачественности, что является решающим фактором для выбора подходящего варианта дальнейшего лечения.

Objective

Objective. To evaluate the efficiency of ASL-perfusion as a method of estimating of hemodynamics and detection of residual tumor tissue after surgical treatment of glioblastoma.

Material and methods

Material and methods. 56 patients after brain tumor’s surgical resection of glioblastoma (GRADE IV). CBF values were determined in 3 different areas - in the presumed tumor tissue with maximum perfusion, in the postoperative scar tissue and in the deep white matter of the opposite hemisphere. All patients were divided into 2 groups according to CBF value.

Results

Results. 1st group: 38 (67.9%) patients - the average CBF in suspected tumor was 137.6±35.2 (79.6-227.6) ml/100 g/min. It was 6-8 times higher than CBF in the deep white matter of the opposite hemisphere, and 5-6 times higher than in the postoperative scars.

2nd group

2nd group: 18 (32.1%) patients with no pathological elevation of CBF in postoperative scar tissue. CBF there was 22.3±5.9 (13.9-37.1) ml/100 g/min. CBF in white matter in the contralateral hemisphere was similar.

There was no significant differences in CBF of scar tissue (p=0,52) and in white matter of contralateral hemisphere (p=0,96) in both groups.

Conclusion

Conclusion. The possibilities of ASL-perfusion are enough to estimating of hemodynamics and detection of residual tumor tissue after surgical removed glioblastoma.

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The authors declare that there are no conflicts of interest present.