rentradВестник рентгенологии и радиологииJournal of radiology and nuclear medicine0042-46762619-0478Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists10.20862/0042-4676-2018-99-6-295-304rentrad-396Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL RESEARCHПрименение диффузионно-тензорной визуализации для оценки микроструктурной целостности вещества головного мозга у пациентов с болезнью АльцгеймераThe use of diffusion-tensor imaging to assess microstructural integrity of white matter of patients with Alzheimer’s diseasehttps://orcid.org/0000-0002-4741-1988ПерепеловВ. А.PerepelovV. A.

Перепелов Всеволод Андреевич - врач-рентгенолог Клиники нервных болезней им. А.Я. Кожевникова.

Ул. Трубецкая, 8, стр. 2, Москва, 119991

Vsevolod A. Perepelov - Radiologist of A.Ya. Kozhevnikov Clinic of Nervous System Diseases.

Ul. Trubetskaya, 8, stroenie 2, Moscow, 119991

vsevolod.perepelov@gmail.comhttps://orcid.org/0000-0001-5533-214XСолодовниковВ. И.SolodovnikovV. I.

Кандидат технических наук, старший научный сотрудник.

Ул. Маршала Бирюзова, 7а, Одинцово, 143000

Cand. Tech. Sc., Senior Researcher.

Ul. Marshala Biryuzova, 7a, Odintsovo,143000

https://orcid.org/0000-0002-5649-2193СиницынВ. Е.SinitsynV. E.

Доктор медицинских наук, профессор, заведующий кафедрой лучевой диагностики и лучевой терапии МГУ им. М.В. Ломоносова.

Ломоносовский пр-т, 27, корп. 1, Москва, 119992; Ул. Баррикадная, 2/1, Москва, 125993

Dr. Med. Sc., Professor, Chief of Chair of Radiology and Radiotherapy, Lomonosov Moscow State University.

Lomonosovskiy prospect, 27, korpus 1, Moscow, 119992; ul. Barrikadnaya, 2/1, Moscow, 125993

https://orcid.org/0000-0002-1951-930XПерепеловаЕ. М.PerepelovaE. M.

Кандидат медицинских наук, заведующая отделением лучевой диагностики Университетской детской клинической больницы.

Ул. Трубецкая, 8, стр. 2, Москва, 119991

Cand. Med. Sc., Head of Department of Radiology of the University Pediatric Clinic.

Ul. Trubetskaya, 8, stroenie 2, Moscow, 119991

https://orcid.org/0000-0002-3110-4764КоберскаяН. Н.KoberskayaN. N.

Кандидат медицинских наук, ассистент кафедры нервных болезней и нейрохирургии.

Ул. Трубецкая, 8, стр. 2, Москва, 119991

Cand. Med. Sc., Assistant of Chair of Nervous Diseases and Neurosurgery.

Ul. Trubetskaya, 8, stroenie 2, Moscow, 119991

https://orcid.org/0000-0001-7825-5992ГридинВ. Н.GridinV. N.

Доктор технических наук, профессор, научный руководитель.

Ул. Маршала Бирюзова, 7а, Одинцово, 143000

Dr. Tech. Sc., Professor, Scientific Adviser.

Ul. Marshala Biryuzova, 7a, Odintsovo,143000

https://orcid.org/0000-0002-8255-5645ЯхноН. Н.YakhnoN. N.

Доктор медицинских наук, профессор кафедры нервных болезней и нейрохирургии, академик РАН, заведующий отделом неврологии научно-технологического парка биомедицины.

Ул. Трубецкая, 8, стр. 2, Москва, 119991

Dr. Med. Sc., Professor of Chair of Nervous Diseases and Neurosurgery, Academician of the Russian Academy of Sciences, Head of Neurology Department of Biomedicine Technopark.

Ul. Trubetskaya, 8, stroenie 2, Moscow, 119991

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава РоссииРоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБУН «Центр информационных технологий в проектировании» РАНРоссияCenter of Information Technologies in Design, Russian Academy of SciencesRussian FederationФГБОУ ВО Московский государственный университет им. М.В. Ломоносова; ГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияLomonosov Moscow State University; Russian Medical Academy of Сontinuous Professional Education, Ministry of Health of Russian FederationRussian Federation201802012019996295304Copyright © Перепелов В.А., Солодовников В.И., Синицын В.Е., Перепелова Е.М., Коберская Н.Н., Гридин В.Н., Яхно Н.Н., 20192019Перепелов В.А., Солодовников В.И., Синицын В.Е., Перепелова Е.М., Коберская Н.Н., Гридин В.Н., Яхно Н.Н.Perepelov V.A., Solodovnikov V.I., Sinitsyn V.E., Perepelova E.M., Koberskaya N.N., Gridin V.N., Yakhno N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.russianradiology.ru/jour/article/view/396

Цель исследования - сравнить показатели диффузионнотензорной визуализации (diffusion tensor imaging - DTI) в различных областях головного мозга у больных с болезнью Альцгеймера (БА) с изолированным нейродегенеративным процессом и пациентов с БА и церебральной микроангио-патией (ЦМ).

Материал и методы

Материал и методы. Обследованы 20 больных БА в возрасте 66 ±10 лет. У 11 пациентов имелся изолированный нейродегенеративный процесс, у 9 - сочетанное поражение головного мозга (БА+ЦМ). Исследование проводилось на магнитно-резонансном томографе Siemens Magnetom Skyra с индукцией магнитного поля 3 Т. МР-протокол обследования пациентов включал проведение DTI. С помощью программы для постпроцессорной обработки полученных данных Olea Medical Sphere 3.0 в ручном режиме измерялись фракционная анизотропия (FA), средняя диффузионная способность (MD), аксиальный и радиальный коэффициенты диффузии (AxD и RxD) в различных областях головного мозга.

Результаты

Результаты. Значимые различия показателей DTI (FA, MD, AxD, RxD), свидетельствующие о более выраженном нарушении микроструктурной целостности белого вещества у больных с сочетанной ЦМ по сравнению с пациентами с изолированным нейродегенеративным процессом, отмечались в области средней таламической лучистости, верхних и нижних продольных пучках и колене мозолистого тела.

Заключение

Заключение. DTI является информативным методом, обладающим высокой чувствительностью в определении различий в нарушении микроструктурной целостности тканей головного мозга у больных с БА и ЦМ по сравнению с лицами с изолированным нейродегенеративным процессом.

Objective

Objective. To compare diffusion-tensor imaging (DTI) measures in different anatomic regions of the brain in patients with an isolated Alzheimer's disease (AD) and patients with AD and small-vessel disease (SVD).

Material and methods

Material and methods. 20 AD patients, aged 66 (±10), of whom 11 AD patients had an isolated neurodegenerative process and 9 patients, who were diagnosed with AD+SVD, were examined. A research was made on a 3 T Siemens Magnetom Skyra MR-scanner. All participants underwent the same imaging protocol, which included standard clinical- and diffusion tensor pulse sequences. With an MR-image processing software package Olea Medical Sphere 3.0, fractional anisotropy (FA), mean diffusivity (MD), axial and radial diffusivity (AxD and RxD) were measured in different brain regions.

Results

Results. Significant differences in DTI measures (FA, MD, AxD, RxD), indicating more severe white matter microstructural damage in AD+SVD patients, compared with patients with an isolated AD, were observed in middle thalamic radiation, upper and lower longitudinal bundles, posterior part of cingulate gyrus and genu of corpus callosum.

Conclusion

Conclusion. DTI is an informative method, highly sensitive in detecting difference in white matter microstructural integrity of brain tissue in individuals with an isolated AD and patients with AD+SVD.

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The authors declare that there are no conflicts of interest present.