rentradВестник рентгенологии и радиологииJournal of radiology and nuclear medicine0042-46762619-0478Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists10.20862/0042-4676-2017-98-6-320-326rentrad-280Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWS OF LITERATUREФУНКЦИОНАЛЬНАЯ И ДИФФУЗИОННО-ТЕНЗОРНАЯ МАГНИТНО-РЕЗОНАНСНАЯ ТОМОГРАФИЯ В РАННЕЙ ДИАГНОСТИКЕ БОЛЕЗНИ АЛЬЦГЕЙМЕРАFUNCTIONAL AND DIFFUSION-TENSOR MAGNETIC RESONANCE IMAGING IN DETECTION OF ALZHEIMER’S DISEASE ON EARLY STAGEShttps://orcid.org/0000-0002-5649-2193СиницынВ. Е.SinitsynV. E.

Доктор медицинских наук, профессор, директор Центра лучевой диагностики ЛРЦ.

MD, PhD, DSc, Professor, Director of Diagnostic Radiology Center of FCTR.

Ivan’kovskoe shosse, 3, Moscow, 125367; Ul. Barrikadnaya, 2/1, Moscow, 125993

https://orcid.org/0000-0001-7825-5992ГридинВ. Н.GridinV. N.

Доктор технических наук, профессор, научный руководитель ЦИТП.

Ул. Маршала Бирюзова, 7а, Одинцово, 143000

Dr. Tech. Sc., Professor, Scientific Director.

Ul. Marshala Biryuzova, 7a, Odintsovo,143000

https://orcid.org/0000-0002-1951-930XПерепеловаЕ. М.PerepelovaE. M.

Кандидат медицинских наук, заведующая отделением лучевой диагностики.

Ул. Трубецкая, 8, стр. 2, Москва, 119991

MD, PhD, Head of Department of Radiology.

Ul. Trubetskaya, 8, stroenie 2, Moscow, 119991

https://orcid.org/0000-0003-4626-2877МеркуловаМ. С.MerkulovaM. S.

Меркулова Мария Сергеевна - аспирант.

Ул. Баррикадная, 2/1, Москва, 125993

Postgraduate.

Ul. Barrikadnaya, 2/1, Moscow, 125993

maria_merkulova@yahoo.comФГАУ «Лечебно-реабилитационный центр» Минздрава России; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияFederal Center of Treatment and Rehabilitation, Ministry of Health of the Russian Federation; Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian FederationRussian FederationФГБУН «Центр информационных технологий в проектировании» РАНРоссияCenter of Information Technologies in Design, Russian Academy of SciencesRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава РоссииРоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian FederationRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияRussian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian FederationRussian Federation201727122017986320326Copyright © Синицын В.Е., Гридин В.Н., Перепелова Е.М., Меркулова М.С., 20172017Синицын В.Е., Гридин В.Н., Перепелова Е.М., Меркулова М.С.Sinitsyn V.E., Gridin V.N., Perepelova E.M., Merkulova M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.russianradiology.ru/jour/article/view/280

Болезнь Альцгеймера (БА) является наиболее распространенной формой деменции среди нейродегенеративных заболеваний. Новые передовые методы магнитно-резонансной томографии, такие как функциональная (фМРТ) и диффузионно-тензорная (ДТ-МРТ) визуализация, позволяют оценить изменения вещества головного мозга при БА на микроструктурном и функциональном уровнях и могут быть использованы в диагностике данного патологического процесса на ранних этапах когнитивных нарушений. В представленном литературном обзоре был выполнен поиск литературных источников в электронных базах данных и научных библиотеках PubMed, Medscape, Elsevier, Cyberleninka, по материалам которых выделены достоинства и недостатки использования фМРТ и ДТ-МРТ при БА, а также оценено клиническое применение этих методов в диагностике ранней стадии БА.

Alzheimer's disease (AD) is the most common form of dementia among neurodegenerative diseases. New advanced methods of magnetic resonance imaging, such as functional (fMRI) and diffusiontensor imaging (DT-MRI), can evaluate changes in brain matter of AD at the microstructural and functional levels and can be used in the diagnostics of this pathological process on early stages of cognitive impairment. In this review, a literature search was made in electronic databases and scientific libraries of PubMed, Medscape, Elsiever, Cyberleninka. The review highlighted the merits and demerits of fMRI and DT-MRI, the clinical application of this methods in diagnosis of AD on early stage were also assessed.

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The authors declare that there are no conflicts of interest present.