<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rentrad</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник рентгенологии и радиологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of radiology and nuclear medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0042-4676</issn><issn pub-type="epub">2619-0478</issn><publisher><publisher-name>Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20862/0042-4676-2016-97-5-306-313</article-id><article-id custom-type="elpub" pub-id-type="custom">rentrad-172</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS OF LITERATURE</subject></subj-group></article-categories><title-group><article-title>Радионуклидная тераностика злокачественных образований</article-title><trans-title-group xml:lang="en"><trans-title>Radionuclide teranostic of malignancies</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор, заместитель директора по научной работе и инновационной деятельности, руководитель отделения радионуклидной диагностики;</p></bio><bio xml:lang="en"><p>MD, PhD, DSc, Professor, Deputy Director for Research and Innovation, Head of the Nuclear Medicine Department</p></bio><email xlink:type="simple">chernov@oncology.tomsk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Брагина</surname><given-names>О. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Bragina</surname><given-names>O. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., мл. науч. сотр.</p></bio><bio xml:lang="en"><p>MD, PhD, Junior Researcher</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синилкин</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Sinilkin</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., ст. науч. сотр.</p></bio><bio xml:lang="en"><p>MD, PhD, Senior Researcher</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Медведева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Medvedeva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., ст. науч. сотр.</p></bio><bio xml:lang="en"><p>MD, PhD, Senior Researcher</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зельчан</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zel’chan</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., врач-радиолог</p></bio><bio xml:lang="en"><p>MD, PhD, Radiologist</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Томский национальный исследовательский медицинский центр РАН», Кооперативный пер., 5, Томск, 634050, Российская Федерация&#13;
ФГАОУ ВО «Национальный исследовательский Томский политехнический университет», пр-т Ленина, 30, Томск, 634050, Российская Федерация</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativnyy pereulok, 5, Tomsk, 634050, Russian Federation;&#13;
National Research Tomsk Polytechnic University, prospekt Lenina, 30, Tomsk, 634050, Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>01</day><month>11</month><year>2016</year></pub-date><volume>97</volume><issue>5</issue><fpage>306</fpage><lpage>313</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чернов В.И., Брагина О.Д., Синилкин И.Г., Медведева А.А., Зельчан Р.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Чернов В.И., Брагина О.Д., Синилкин И.Г., Медведева А.А., Зельчан Р.В.</copyright-holder><copyright-holder xml:lang="en">Chernov V.I., Bragina O.D., Sinilkin I.G., Medvedeva A.A., Zel’chan R.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.russianradiology.ru/jour/article/view/172">https://www.russianradiology.ru/jour/article/view/172</self-uri><abstract><p>В данном обзоре представлена основная информация, касающаяся относительно нового перспективного направления, получившего название «тераностика», рассматриваются его главные принципы. Особое внимание уделено изучению подходов при выборе наиболее целесообразных для решения соответствующих диагностических и терапевтических задач радиоизотопов. Также представлены основные направления работы с моноклональными антителами и их использования в радионуклидной тераностике.</p></abstract><trans-abstract xml:lang="en"><p>This review shows some basic information regarding the relatively new and one of the promising areas, called "theranostics" and also discusses its basic principles. Special attention is paid to the study of approaches in selecting the most appropriate in the application of radioisotopes for solutions appropriate diagnostic and therapeutic applications. Also presented the main directions in the work with monoclonal antibodies and their use in radionuclide theranostics.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>персонализированная медицина</kwd><kwd>тераностика</kwd><kwd>радиоизотопы</kwd><kwd>моноклональные антитела</kwd><kwd>рецепторы эпидермального фактора роста</kwd><kwd>злокачественные образования</kwd></kwd-group><kwd-group xml:lang="en"><kwd>personalized medicine</kwd><kwd>theranostics</kwd><kwd>radioisotopes</kwd><kwd>monoclonal antibodies</kwd><kwd>receptors of epidermal growth factor</kwd><kwd>malignancies</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chan I.S., Ginsburg G.S. Personalized medicine: progress and promise. Ann. Rev. Genomics Hum. Genet. 2011; 12: 217–44.</mixed-citation><mixed-citation xml:lang="en">Chan I.S., Ginsburg G.S. Personalized medicine: progress and promise. Ann. Rev. Genomics Hum. Genet. 2011; 12: 217–44.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Тюльпаков А.Н., Чехонин В.П., Баклаушев В.П., Арчаков А.И., Мошковский С.А. Персонифицированная медицина: современное состояние и перспективы. Вестник РАМН. 2012; 12: 4–12.</mixed-citation><mixed-citation xml:lang="en">Dedov I.I., Tyul’pakov A.N., Chekhonin V.P., Baklaushev V.P., Archakov A.I., Moshkovskiy S.A. Personalized medicine: current situation and prospects. Byulleten’ RAMN (Bulletin of Russian Academy of Medical Sciences. Russian journal). 2012; 12: 4–12 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Scudellari M. Genomics contest underscores challenges of personalized medicine. Nat. Med. 2012; 18: 312–26.</mixed-citation><mixed-citation xml:lang="en">Scudellari M. Genomics contest underscores challenges of personalized medicine. Nat. Med. 2012; 18: 312–26.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hoggatt J. Personalized medicine trends in molecular diagnostics: exponential growth expected in the next ten years. Mol. Diagn. Ther. 2011; 15: 53–5.</mixed-citation><mixed-citation xml:lang="en">Hoggatt J. Personalized medicine trends in molecular diagnostics: exponential growth expected in the next ten years. Mol. Diagn. Ther. 2011; 15: 53–5.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hodgson D.R., Wellings R., Harbron C. Practical perspectives of personalized healthcare in oncology. N. Biothechnol. 2012; 29 (Suppl. 6): 656–64.</mixed-citation><mixed-citation xml:lang="en">Hodgson D.R., Wellings R., Harbron C. Practical perspectives of personalized healthcare in oncology. N. Biothechnol. 2012; 29 (Suppl. 6): 656–64.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Thomson A. Why do therapeutic drug monitoring. Pharm. J. 2004; 273: 153–5.</mixed-citation><mixed-citation xml:lang="en">Thomson A. Why do therapeutic drug monitoring. Pharm. J. 2004; 273: 153–5.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Idée J.M., Louguet S., Ballet S., Сorot C. Theranostics and contrast-agents for medical imaging: a pharmaceutical company viewpoint. Quant Imaging Med. Surg. 2013; 3 (Suppl. 6): 292–7.</mixed-citation><mixed-citation xml:lang="en">Idée J.M., Louguet S., Ballet S., Сorot C. Theranostics and contrast-agents for medical imaging: a pharmaceutical company viewpoint. Quant Imaging Med. Surg. 2013; 3 (Suppl. 6): 292–7.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kelkar S.S., Reineke T.M. Theranostics: combining imaging and therapy. Bioconjug. Chem. 2011; 22: 1879–903.</mixed-citation><mixed-citation xml:lang="en">Kelkar S.S., Reineke T.M. Theranostics: combining imaging and therapy. Bioconjug. Chem. 2011; 22: 1879–903.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Полянский О.Л., Лебеденко Е.Н., Деев С.М. ERBB онкогены – мишени моноклональных антител. Биохимия. 2012; 77 (Приложение 3): 289–311.</mixed-citation><mixed-citation xml:lang="en">Polyanovskiy O.L., Lebedenko E.N., Deev S.M. ERBB oncogenes as targets for monoclonal antibodies. Biokhimiya (Biochemistry. Russian journal). 2012; 77 (Suppl. 3): 289–311 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Baselga J., Gelmon K.A., Verma S., Wardley A., Conte P., Miles D. et al. Phase II trial of pertuzumab and trastuzumab in patients with human growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J. Clin. Oncol. 2010; 28: 1138–44.</mixed-citation><mixed-citation xml:lang="en">Baselga J., Gelmon K.A., Verma S., Wardley A., Conte P., Miles D. et al. Phase II trial of pertuzumab and trastuzumab in patients with human growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J. Clin. Oncol. 2010; 28: 1138–44.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Blackwell K.L., Burstein H.J., Storniolo A.M., Rugo H., Sledge G., Koehler M. et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumabrefractory metastatic breast cancer. J. Clin. Oncol. 2010; 28: 1124–30.</mixed-citation><mixed-citation xml:lang="en">Blackwell K.L., Burstein H.J., Storniolo A.M., Rugo H., Sledge G., Koehler M. et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumabrefractory metastatic breast cancer. J. Clin. Oncol. 2010; 28: 1124–30.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Boussen H., Cristofanilli M., Zaks T., DeSilvio M., Salazar V., Spector N. Phase II study to evaluate the efficacy and safety of neoadjuvant lapatinib plus paclitaxel in patients with inflammatory breast cancer. J. Clin. Oncol. 2010; 28: 3248–55.</mixed-citation><mixed-citation xml:lang="en">Boussen H., Cristofanilli M., Zaks T., DeSilvio M., Salazar V., Spector N. Phase II study to evaluate the efficacy and safety of neoadjuvant lapatinib plus paclitaxel in patients with inflammatory breast cancer. J. Clin. Oncol. 2010; 28: 3248–55.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Burstein H.J., Sun Y., Dirix L.Y., Jiang Z., Paridaens R., Tan A.R. et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbBpositive breast cancer. J. Clin. Oncol. 2010; 28: 1301–7.</mixed-citation><mixed-citation xml:lang="en">Burstein H.J., Sun Y., Dirix L.Y., Jiang Z., Paridaens R., Tan A.R. et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbBpositive breast cancer. J. Clin. Oncol. 2010; 28: 1301–7.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Laverman P., Sosabowski J.K., Boerman O.C., Oyen W.J. Radiolabelled peptides for oncological diagnosis. Eur. J. Nucl. Med. Mol. Imaging. 2012; 39 (Suppl. 1): 78–92.</mixed-citation><mixed-citation xml:lang="en">Laverman P., Sosabowski J.K., Boerman O.C., Oyen W.J. Radiolabelled peptides for oncological diagnosis. Eur. J. Nucl. Med. Mol. Imaging. 2012; 39 (Suppl. 1): 78–92.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Лишманов Ю.Б., Чернов В.И. Национальное руководство по радионуклидной диагностике. Том 1. Томск: STT; 2010.</mixed-citation><mixed-citation xml:lang="en">Lishmanov Yu.B., Chernov V.I. National guide on radionuclide diagnostics. Tomsk: STT; 2010; 1 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Фомин Д.К., Тарарухина О.Б., Назаров А.А., Борисова О.А. Варианты системной лучевой терапии в лечении метастатического поражения скелета. Вестник рентгенологии и радиологии. 2012; 6: 30–4.</mixed-citation><mixed-citation xml:lang="en">Fomin D.K., Tararukhina O.B., Nazarov A.A., Borisova O.A. Possible systemic radiotherapy in the treatment of skeletal metastatic lesions. Vestnik Rentgenologii i Radiologii (Russian Journal of Radiology). 2012; 6: 30–4 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Denoye D., Pouliot N. Radionuclide theranostics in cancer. J. Mol. Imaging Dynam. 2013; 4 (Suppl. 1): 1–2.</mixed-citation><mixed-citation xml:lang="en">Denoye D., Pouliot N. Radionuclide theranostics in cancer. J. Mol. Imaging Dynam. 2013; 4 (Suppl. 1): 1–2.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Baum R.P., Kulkarni H.R. Theranostics: from molecular imaging using Ga-68 labeled tracers and PET/CT to personalized radionuclide therapy – the bad berka experience. Theranostics. 2012; 2: 437–47.</mixed-citation><mixed-citation xml:lang="en">Baum R.P., Kulkarni H.R. Theranostics: from molecular imaging using Ga-68 labeled tracers and PET/CT to personalized radionuclide therapy – the bad berka experience. Theranostics. 2012; 2: 437–47. 19. Hicks R.J. Use of molecular targeted agents for the diagnosis, staging and therapy of neuroendocrine malignancy. Cancer Imaging. 2010; 10: 83–91.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hicks R.J. Use of molecular targeted agents for the diagnosis, staging and therapy of neuroendocrine malignancy. Cancer Imaging. 2010; 10: 83–91.</mixed-citation><mixed-citation xml:lang="en">Jandl T., Revskaya E., Jiang Z., Bryan R.A., Casadevall A., Dadachova E. Complement dependent cytotoxicity of an antibody to melanin in radioimmunotherapy of metastatic melanoma. Immunotherapy. 2013; 5: 357–64.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Jandl T., Revskaya E., Jiang Z., Bryan R.A., Casadevall A., Dadachova E. Complement dependent cytotoxicity of an antibody to melanin in radioimmunotherapy of metastatic melanoma. Immunotherapy. 2013; 5: 357–64.</mixed-citation><mixed-citation xml:lang="en">Beer A.J., Haubner R., Sarbia M., Goebel M., Luderschmidt S., Grosu A.L. et al. Positron emission tomography using [18F] GalactoRGD identifies the level of integrin alpha(v)beta3 expression in man. Clin. Cancer Res. 2006; 12: 3942–9.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Beer A.J., Haubner R., Sarbia M., Goebel M., Luderschmidt S., Grosu A.L. et al. Positron emission tomography using [18F] GalactoRGD identifies the level of integrin alpha(v)beta3 expression in man. Clin. Cancer Res. 2006; 12: 3942–9.</mixed-citation><mixed-citation xml:lang="en">Janssen M.L., Oyen W.J., Dijkgraaf I., Massuger L.F., Frielink C., Edwards D.S. et al. Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model. Cancer Res. 2002; 62: 6146–51.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Janssen M.L., Oyen W.J., Dijkgraaf I., Massuger L.F., Frielink C., Edwards D.S. et al. Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model. Cancer Res. 2002; 62: 6146–51.</mixed-citation><mixed-citation xml:lang="en">Sharkey R.M., Goldenberg D.M. Cancer radioimmunotherapy. Immunotherapy. 2011; 3 (Suppl. 3): 349–70.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sharkey R.M., Goldenberg D.M. Cancer radioimmunotherapy. Immunotherapy. 2011; 3 (Suppl. 3): 349–70.</mixed-citation><mixed-citation xml:lang="en">Kodina G.E. Krasikova R.N. Methods for the preparation of radiopharmaceuticals and radionuclide generator for nuclear medicine. Moscow; 2014 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Кодина Г.Е., Красикова Р.Н. Методы получения радиофармацевтических препаратов и радионуклидных генераторов для ядерной медицины. М.: МЭИ; 2014.</mixed-citation><mixed-citation xml:lang="en">Cutler C.S., Hennkens H.M., Sisay N., Huclier-Markai S., Jurisson S.S. Radiometals for combined imaging and therapy. Chem. Rev. 2013; 113 (Suppl. 2): 858–83.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Cutler C.S., Hennkens H.M., Sisay N., Huclier-Markai S., Jurisson S.S. Radiometals for combined imaging and therapy. Chem. Rev. 2013; 113 (Suppl. 2): 858–83.</mixed-citation><mixed-citation xml:lang="en">Lin F.I., Iagaru A. Current concepts and future directions in radioimmunotherapy. Cur. Drug Discov. Technol. 2010; 7 (Suppl. 4): 253–62.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Lin F.I., Iagaru A. Current concepts and future directions in radioimmunotherapy. Cur. Drug Discov. Technol. 2010; 7 (Suppl. 4): 253–62.</mixed-citation><mixed-citation xml:lang="en">Farrokhi S., Ravanbod M.R., Amiri S., Nabipour I., Assadi M. Radioimmunotherapy-based treatment of cancer. Iran J. Nucl. Med. 2012; 20 (Suppl. 1): 45–53.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Farrokhi S., Ravanbod M.R., Amiri S., Nabipour I., Assadi M. Radioimmunotherapy-based treatment of cancer. Iran J. Nucl. Med. 2012; 20 (Suppl. 1): 45–53.</mixed-citation><mixed-citation xml:lang="en">Kawashima H. Radioimmunotherapy: A Specific Treatment Protocol for Cancer by Cytotoxic Radioisotopes Conjugated to Antibodies. Sci. World J. 2014; 14: 1–10.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kawashima H. Radioimmunotherapy: A Specific Treatment Protocol for Cancer by Cytotoxic Radioisotopes Conjugated to Antibodies. Sci. World J. 2014; 14: 1–10.</mixed-citation><mixed-citation xml:lang="en">Wilken J.A., Maihle N.J. Primary trastuzumab resistance: new tricks for an old drug. Ann. NY Acad. Sci. 2010; 1210: 53–65.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Wilken J.A., Maihle N.J. Primary trastuzumab resistance: new tricks for an old drug. Ann. NY Acad. Sci. 2010; 1210: 53–65.</mixed-citation><mixed-citation xml:lang="en">Chen K.T., Lee T.W., Lo J.M. In vivo examination of (188) Re(I)-tricarbonyl-labeled trastuzumab to target HER2-overexpressing breast cancer. Nucl. Med. Biol. 2009; 36 (Suppl. 4): 355–61.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Chen K.T., Lee T.W., Lo J.M. In vivo examination of (188) Re(I)-tricarbonyl-labeled trastuzumab to target HER2-overexpressing breast cancer. Nucl. Med. Biol. 2009; 36 (Suppl. 4): 355–61.</mixed-citation><mixed-citation xml:lang="en">Rasaneh S., Rajabi H., Babaei M.H., Daha F.J. 177Lu labeling of Herceptin and preclinical validation as a new radiopharmaceutical for radioimmunotherapy of breast cancer. Nucl. Med. Biol. 2010; 37 (Suppl. 8): 949–55.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Rasaneh S., Rajabi H., Babaei M.H., Daha F.J. 177Lu labeling of Herceptin and preclinical validation as a new radiopharmaceutical for radioimmunotherapy of breast cancer. Nucl. Med. Biol. 2010; 37 (Suppl. 8): 949–55.</mixed-citation><mixed-citation xml:lang="en">Song H., Hobbs R.F., Vajravelu R., Huso D.L., Esaias C., Apostolidis C. et al. Radioimmunotherapy of breast cancer metastases with alpha-particle emitter 225Ac: Comparing efficacy with 213Bi and 90Y. Cancer Res. 2009; 69 (Suppl. 23): 8941–8.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Song H., Hobbs R.F., Vajravelu R., Huso D.L., Esaias C., Apostolidis C. et al. Radioimmunotherapy of breast cancer metastases with alpha-particle emitter 225Ac: Comparing efficacy with 213Bi and 90Y. Cancer Res. 2009; 69 (Suppl. 23): 8941–8.</mixed-citation><mixed-citation xml:lang="en">Song H., Shahverdi K., Huso D.L., Esaias C., Fox J., Liedy A. et al. 213Bi (alpha-emitter) – antibody targeting of breast cancer metastases in the neu-N transgenic mouse model. Cancer Res. 2008; 68 (Suppl. 10): 3873–80.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Song H., Shahverdi K., Huso D.L., Esaias C., Fox J., Liedy A. et al. 213Bi (alpha-emitter) – antibody targeting of breast cancer metastases in the neu-N transgenic mouse model. Cancer Res. 2008; 68 (Suppl. 10): 3873–80.</mixed-citation><mixed-citation xml:lang="en">Abbas N., Heyerdahl H., Bruland О.S., Borrebak J., Nesland J., Dahle J. Experimental a-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTAtrastuzumab. EJNMMI Research. 2011; 1: 1–12.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Abbas N., Heyerdahl H., Brul and О.S., Borrebak J., Nesland J., Dahle J. Experimental a-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTAtrastuzumab. EJNMMI Research. 2011; 1: 1–12.</mixed-citation><mixed-citation xml:lang="en">Agulnik M. New approaches to EGFR inhibition for locally advanced or metastatic squamous cell carcinoma of the head and neck (SCCHN). Med. Oncol. 2012; 29: 2481–91.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Agulnik M. New approaches to EGFR inhibition for locally advanced or metastatic squamous cell carcinoma of the head and neck (SCCHN). Med. Oncol. 2012; 29: 2481–91.</mixed-citation><mixed-citation xml:lang="en">Sihver W., Pietzsch J., Krause M., Baumann M., Steinbach J., Pietzsch H.-J. Radiolabeled cetuximab conjugates for EGFR targeted cancer diagnostics and therapy. Pharmaceuticals. 2014; 7: 311–38.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Sihver W., Pietzsch J., Krause M., Baumann M., Steinbach J., Pietzsch H.-J. Radiolabeled cetuximab conjugates for EGFR targeted cancer diagnostics and therapy. Pharmaceuticals. 2014; 7: 311–38.</mixed-citation><mixed-citation xml:lang="en">Rades D., Nadrowitz R., Buchmann I., Hunold P., Noack F., Schild S.E. et al. Radiolabeled cetuximab plus whole-brain irradiation (WBI) for the treatment of brain metastases from non-small cell lung cancer (NSCLC). Strahlenther. Onkol. 2010; 186: 458–62.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Rades D., Nadrowitz R., Buchmann I., Hunold P., Noack F., Schild S.E. et al. Radiolabeled cetuximab plus whole-brain irradiation (WBI) for the treatment of brain metastases from non-small cell lung cancer (NSCLC). Strahlenther. Onkol. 2010; 186: 458–62.</mixed-citation><mixed-citation xml:lang="en">Heskamp S., Boerman O.C., Molkenboer-Kuenen J.D., Oyen W.J., van der Graaf W.T., van Laarhoven H.W. et al. Bevacizumab reduces tumor targeting of antiepidermal growth factor and anti-insulinlike growth factor 1 receptor antibodies. Int. J. Cancer. 2013; 133 (Suppl. 2): 307–14.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Heskamp S., Boerman O.C., Molkenboer-Kuenen J.D., Oyen W.J., van der Graaf W.T., van Laarhoven H.W. et al. Bevacizumab reduces tumor targeting of antiepidermal growth factor and anti-insulinlike growth factor 1 receptor antibodies. Int. J. Cancer. 2013; 133 (Suppl. 2): 307–14.</mixed-citation><mixed-citation xml:lang="en">Kinuya S., Yokoyama K., Koshida K., Mori H., Shiba K., Watanabe N. et al. Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy. Eur. J. Nucl. Med. Mol. Imaging. 2004; 31: 981–5.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Kinuya S., Yokoyama K., Koshida K., Mori H., Shiba K., Watanabe N. et al. Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy. Eur. J. Nucl. Med. Mol. Imaging. 2004; 31: 981–5.</mixed-citation><mixed-citation xml:lang="en">Salaun P.Y., Bodet-Milin C., Frampas E., Oudoux A., Saї-Maurel C., Faivre-Chauvet A. et al. Toxicity and efficacy of combined radioimmunotherapy and bevacizumab in a mouse model of medullary thyroid carcinoma. Cancer. 2010; 116: 1053–8.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Salaun P.Y., Bodet-Milin C., Frampas E., Oudoux A., Saї-Maurel C., Faivre-Chauvet A. et al. Toxicity and efficacy of combined radioimmunotherapy and bevacizumab in a mouse model of medullary thyroid carcinoma. Cancer. 2010; 116: 1053–8.</mixed-citation><mixed-citation xml:lang="en">Kraeber-Bodere F., Bodet-Milin C., Niaudet C., Saї-Maurel C., Moreau A., Faivre-Chauvet A. et al. Comparative toxicity and efficacy of combined radioimmunotherapy and antiangiogenic therapy in carcinoembryonic antigenexpressing medullary thyroid cancer xenograft. J. Nucl. Med. 2010; 51: 624–31.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kraeber-Bodere F., Bodet-Milin C., Niaudet C., Saї-Maurel C., Moreau A., Faivre-Chauvet A. et al. Comparative toxicity and efficacy of combined radioimmunotherapy and antingiogenic therapy in carcinoembryonic antigenexpressing medullary thyroid cancer xenograft. J. Nucl. Med. 2010; 51: 624–31.</mixed-citation><mixed-citation xml:lang="en">Baklaushev V.P., Pavlov K.A., Chekhonin V.P. The monoclonal antibody in the diagnosis of highgrade lymphomas. Biomeditsinskaya Khimiya (Biomedical Chemistry. Russian journal). 2009; 2: 140–54 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Баклаушев В.П., Павлов К.А., Чехонин В.П. Моноклональные антитела в диагностике низкодифференцированных лимфом. Биомедицинская химия. 2009; 2: 140–54.</mixed-citation><mixed-citation xml:lang="en">Kitson S.L., Cuccurullo V., Moody T.S., Mansi L. Radionuclide antibody-conjugates, a targeted therapy towards cancer. Current Radiopharm. 2013; 6 (Suppl. 2): 57–71.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Kitson S.L., Cuccurullo V., Moody T.S., Mansi L. Radionuclide antibody-conjugates, a targeted therapy towards cancer. Current Radiopharm. 2013; 6 (Suppl. 2): 57–71.</mixed-citation><mixed-citation xml:lang="en">Boerman O.C., van Schaijk F.G., Oyen W.J.G., Corstens F.H. Pretargeted radioimmunotherapy of cancer: progress step by step. J. Nucl. Med. 2003; 44 (Suppl. 3): 400–11.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Boerman O.C., van Schaijk F.G., Oyen W.J.G., Corstens F.H. Pretargeted radioimmunotherapy of cancer: progress step by step. J. Nucl. Med. 2003; 44 (Suppl. 3): 400–11.</mixed-citation><mixed-citation xml:lang="en">Semenova A.I. Basic principles of systemic therapy Her-2 positive breast cancer. Prakticheskaya Onkologiya (Practical Oncology. Russian journal). 2010; 11 (Suppl. 4):</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Семенова А.И. Основные принципы системной терапии Her-2-позитивного рака молочной железы. Практическая онкология. 2010; 11 (4): 239–46.</mixed-citation><mixed-citation xml:lang="en">239–46 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Pastuskovas C.V., Mundo E.E., Williams S.P., Nayak T.K., Ho J., Ulufatu S. et al. Effects of antiVEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model. Mol. Cancer Ther. 2012; 11 (Suppl. 3): 752–62.</mixed-citation><mixed-citation xml:lang="en">Pastuskovas C.V., Mundo E.E., Williams S.P., Nayak T.K., Ho J., Ulufatu S. et al. Effects of antiVEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model. Mol. Cancer Ther. 2012; 11 (Suppl. 3): 752–62.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
