References

rentrad

Вестник рентгенологии и радиологии

Journal of radiology and nuclear medicine

0042-46762619-0478

Limited Liability Company "LUCHEVAYA DIAGNOSTIKA", Russian Association of Radiologists

10.20862/0042-4676-2016-97-4-243-256

rentrad-159

Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

REVIEWS OF LITERATURE

Имеет ли клиническое значение стабильность гадолинийсодержащих магнитно-резонансных контрастных средств?

Нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance?

https://orcid.org/0000-0001-7534-4818

Панов

В. О.

Panov

V. O.

к. м. н., доцент кафедры лучевой диагностики, лучевой терапии и медицинской физики,

ул. Баррикадная, 2/1, Москва, 125993

MD, PhD, Associate Professor of Department of Radiation Diagnosis, Radiotherapy and Medical Physics,

ul. Barrikadnaya, 2/1, Moscow, 125993

https://orcid.org/0000-0001-8887-4420

Шимановский

Н. Л.

Shimanovskiy

N. L.

д. м. н., профессор, чл.-корр. РАН, заведующий кафедрой молекулярной фармакологии и радиобиологии им. академика П.В. Сергеева,

ул. Островитянова, 1, Москва, 117997

MD, PhD, DSc, Professor, Corresponding Member of Russian Academy of Sciences, Head of P.V. Sergeev Department of Molecular Pharmacology and Radiobiology,

ul. Ostrovityanova, 1, Moscow, 117997

shimannn@yandex.ru

ГБОУ ДПО «Российская медицинская академия последипломного образования» Министерства здравоохранения РФРоссияRussian Medical Academy of Postgraduate Education, Ministry of Health of the RFRussian Federation

ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения РФРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of the RFRussian Federation

2016

13092016

974243256

2016

Панов В.О., Шимановский Н.Л.

Panov V.O., Shimanovskiy N.L.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.russianradiology.ru/jour/article/view/159

Приведены современные сведения об острых и очень поздних побочных реакциях, возникающих при использовании гадолинийсодержащих магнитно-резонансных контрастных средств (ГМРКС). Рассмотрена роль термодинамической и кинетичес- кой стабильности ГМРКС в депонировании гадолиния в тканях, в том числе головном мозге, развитии псевдогипокальциемии и нефрогенного системного фиброза (НСФ). В результате анализа данных о механизмах депонирования гадолиния в клетках организма и механизмах цитотоксичности от химического строения существующих ГМРКС сделан вывод, что для снижения накопления гадолиния в клетках и риска развития НСФ целесообразно использовать стабильные макроциклические препараты, такие как гадобутрол.

It has been given current information about acute and late adverse reactions arising from the use of gadolinium magnetic resonance contrast agents (GMRCA). The role of thermodynamic and kinetic stability GMRCA in the deposition of gadolinium in tissues, including the brain, the development of pseudohypoglycemia and nephrogenic systemic fibrosis (NSF) is considerated. After analysis of data on mechanisms of deposition of gadolinium in the body's cells and mechanisms of cytotoxicity on the chemical structure of existing GMRCA it is concluded that for reducing the accumulation of gadolinium in cells and the risk of development of NSF is advisable to use stable macrocyclic agents such as gadobutrol.

гадолинийсодержащие магнитно-резонансные контрастные средствастабильностьдепонирование гадолиниягадобутрол

gadolinium magnetic resonance contrast agentsstabilitydeposition of gadoliniumgadobutrol

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The authors declare that there are no conflicts of interest present.